Results 31 to 40 of about 83,265 (304)

Impact of central antagonist of cholecystokinin-1 receptors GB-115 on cognitive functions in patients with Generalized Anxiety Disorder

open access: yesEuropean Psychiatry, 2022
Introduction Generalized anxiety disorder (GAD) is associated with reduced attention, inhibition, decrease of processing speed. The impact of a new peptide antagonist of central cholecystokinin-1 receptors (GB-115) on cognitive processes in patients ...
O. Dorofeeva   +3 more
doaj   +1 more source

Conduction of activity between muscles in the terminal region of the common bile duct and in the neighboring duodenum [PDF]

open access: yes, 1976
The relationship between muscle activity at the terminal region of the common bile duct and the duodenal muscle was examined in rabbits. The rhythmic muscle activity in the terminal region was synchronous with duodenal muscle activity.
Fukuda, Hiroyuki, Nakayama, Sosogu
core   +1 more source

Cholesterol gallstone formation in overweight mice establishes that obesity per se is not linked directly to cholelithiasis risk

open access: yesJournal of Lipid Research, 2002
The relationship between obesity and cholesterol cholelithiasis is not well understood at physiologic or genetic levels. To clarify whether obesity per se leads to increased prevalence of cholelithiasis, we examined cholesterol gallstone susceptibility ...
Guylaine Bouchard   +4 more
doaj   +1 more source

Structure-activity relationship data and ligand-receptor interactions identify novel agonists consistent with sulfakinin tissue-specific signaling in Drosophila melanogaster heart

open access: yesFrontiers in Bioscience-Landmark, 2022
Background: The structures and activities of invertebrate sulfakinins that influence gut motility and heart rate are like the vertebrate cholecystokinin (CCK) peptides.
Ruthann Nichols   +2 more
doaj   +1 more source

Protective effects of urocortin 2 against caerulein-induced acute pancreatitis. [PDF]

open access: yes, 2019
Because little is known about the role of corticotropin-releasing factor (CRF) agonists in regulating responses in pancreatitis, we evaluated the effects of urocortin 2 (UCN2) and stressin1 in caerulein-induced acute pancreatitis (AP) model in rats. Male
Bhargava, Aditi   +6 more
core   +1 more source

Regulation of CCK-induced ERK1/2 activation by PKC epsilon in rat pancreatic acinar cells

open access: yesAIMS Molecular Science, 2017
The extracellular signal-regulated kinase ERK1/2 is activated in pancreatic acinar cells by cholecystokinin (CCK) and other secretagogues with this activation mediated primarily by protein kinase C (PKC).
Chenwei Li, John A. Williams
doaj   +1 more source

Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit

open access: yeseLife, 2016
The nucleus of the solitary tract (NTS) is a key gateway for meal-related signals entering the brain from the periphery. However, the chemical mediators crucial to this process have not been fully elucidated.
G. D'Agostino   +10 more
semanticscholar   +1 more source

A double-label study of efferent projections from the Edinger-Westphal nucleus in goldfish and kelp bass [PDF]

open access: yes, 1988
The Edinger-Westphal nucleus in goldfish was identified by retrograde labeling from the ciliary ganglion. In the same animals a few neurons near this nucleus (perinuclear Edinger-Westphal neurons) were labeled by a different retrograde tracer injected ...
Akert   +22 more
core   +1 more source

Utilizing Peptide Ligand GPCRs to Image and Treat Pancreatic Cancer

open access: yesBiomedicines, 2018
It is estimated that early detection of pancreatic ductal adenocarcinoma (PDAC) could increase long-term patient survival by as much as 30% to 40% (Seufferlein, T. et al., Nat. Rev. Gastroenterol. Hepatol. 2016, 13, 74–75).
Gail L. Matters, John F. Harms
doaj   +1 more source

Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target

open access: yesMolecular Pain, 2016
Burn injury is a cause of significant mortality and morbidity worldwide and is frequently associated with severe and long-lasting pain that remains difficult to manage throughout recovery.
Kathleen Yin   +3 more
semanticscholar   +1 more source

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