Results 81 to 90 of about 83,265 (304)

Potassium–chloride cotransporter 2 activity dampens induced ictal‐like activity in neocortical slices containing the seizure propagation zone of temporal lobe epilepsy patients

Epilepsia, EarlyView.
The K⁺/Cl− cotransporter (KCC2) limits induced ictal‐like events and their spread in the supragranular layer of human neocortical slices from the seizure‐propagation zone of temporal lobe epilepsy patients. Cl⁻ extrusion is present in supragranular pyramidal neurons but limited under high somatic Cl⁻ load.
Alice Falck, Janna Lehnhoff, Mahraz Behbood, Egor Byvaltcev, Annette Aigner, Helena Radbruch, Pawel Fidzinski, Jan‐Hendrik Schleimer, Gabriel M. S. Janach, Noah Döhne, Julia Onken, Thilo Kalbhenn, Thomas Sauvigny, Rudolf A. Deisz, Susanne Schreiber, Martin Holtkamp, Ulf Strauss   +16 more
wiley   +1 more source

Mesenteric Vascular Dysregulation and Intestinal Inflammation Accompanies Experimental Spinal Cord Injury

, 2016
Cervical and high thoracic spinal cord injury (SCI) drastically impairs autonomic nervous system function. Individuals with SCI at thoracic spinal-level 5 (T5) or higher often present cardiovascular disorders that include resting systemic arterial ...
Besecker, Emily Swartz, Cooper, Timothy K., Deiter, Gina M., Holmes, Gregory Michael, Pironi, Nicole   +4 more
core   +1 more source

Gut Microbial Changes in Diabetic db/db Mice and Recovery of Microbial Diversity upon Pirfenidone Treatment

Microorganisms, 2020
The leptin receptor-deficient db/db mouse model is an accepted in vivo model to study obesity, type 2 diabetes, and diabetic kidney disease. Healthy gastrointestinal (GI) microbiota has been linked to weight loss, improved glycemic control, and ...
Harinder Singh, Satoshi Miyamoto, Manjula Darshi, Manolito G. Torralba, Keehwan Kwon, Kumar Sharma, Rembert Pieper   +6 more
doaj   +1 more source

The proteomic differences and expression of fatty acid‐binding protein 6 (FABP6) associated with gastrointestinal injury in horses with oral administration of a clinical dose of phenylbutazone

Equine Veterinary Journal, EarlyView.
Abstract Background Phenylbutazone (PBZ) can potentially induce gastrointestinal ulceration, and early detection of PBZ‐induced gastroenteropathy will be useful for the diagnosis, treatment, and prevention of PBZ toxicity. Objectives To identify putative proteins associated with equine gastric ulcer syndrome after clinical dose (4.4 mg/kg ...
Ruethaiwan Vinijkumthorn, Nawarus Prapaiwan, Thanapon Chotikaprakal, Phirom Prompiram, Narumon Phaonakrop, Sittiruk Roytrakul, Parichart Tesena   +6 more
wiley   +1 more source

Differential sensitivity of types 1 and 2 cholecystokinin receptors to membrane cholesterol

Journal of Lipid Research, 2012
Recent studies indicate that membrane cholesterol can associate with G protein-coupled receptors (GPCRs) and affect their function. Previously, we reported that manipulation of membrane cholesterol affects ligand binding and signal transduction of the ...
Ross M. Potter, K. Harikumar, S.Vincent Wu, L. Miller   +3 more
semanticscholar   +1 more source

A walnut-containing meal had similar effects on early satiety, CCK, and PYY, but attenuated the postprandial GLP-1 and insulin response compared to a nut-free control meal. [PDF]

, 2017
Regular nut consumption is associated with lower adiposity and reduced weight gain in adulthood. Walnut feeding studies have observed minimal effect on body weight despite potential additional energy intake.
Barkai, Hava-Shoshana, Flatt, Shirley W, Heath, Dennis D, Pakiz, Bilge, Rock, Cheryl L   +4 more
core   +2 more sources

Lower density of calretinin‐immunopositive neurons in the putamen of subjects with schizophrenia

Journal of Anatomy, Volume 246, Issue 4, Page 505-516, April 2025.
Recent neuroimaging and histological studies highlight the striatum as a key area involved in SCH, but the specific impairment of neuronal subtypes in subcortical structures is not fully understood. This study is the first detailed investigation of neuroanatomical changes in the putamen in SCH, specifically examining the density of calretinin ...
Paz Kelmer, Paulina Hoppa, Erzsébet Frank, Teadora Tyler, Istvan Adorjan   +4 more
wiley   +1 more source

Staging chronic pancreatitis with exocrine function tests: Are we better? [PDF]

, 2017
Chronic pancreatitis (CP) is an inflammatory disease of the pancreas evolving in progressive fibrotic disruption of the gland with exocrine and endocrine pancreatic insufficiency.
MOLETTA, LUCIA, SPERTI, COSIMO
core   +1 more source

Role of brain cholecystokinin in neuronal homeostasis: rediscovering novel functions of an old neuropeptide [PDF]

Exploration of Drug Science
Cholecystokinin (CCK) is the most prevalent neuropeptide in the brain, where it affects satiety, pain modulation, memory, and anxiety. Its effects are mediated by GPCRs known as the “alimentary (gastrointestinal)” CCK1r (CCK 1 receptor) and the brain ...
Santiago J. Ballaz
doaj   +1 more source

Impact of long‐term maternal high‐fat, high‐sugar feeding on gastric vagal afferent responses and feeding behaviour in mouse offspring

Experimental Physiology, EarlyView.
Abstract Poor maternal nutrition and excessive gestational weight gain predict future development of obesity in offspring. Preclinically, maternal obesity induced by a high‐fat, high‐sugar diet (HFHSD) induces hyperphagia and obesity in offspring. We hypothesized that this might, in part, reflect reduced peripheral gastric vagal afferent (GVA) satiety ...
Georgia S. Clarke, Hui Li, Elaheh Heshmati, Kelly M. Gembus, Stephanie E. O'Hara, Lisa M. Nicholas, Kathryn L. Gatford, Amanda J. Page   +7 more
wiley   +1 more source