Results 81 to 90 of about 36,127 (235)
GLP‐1 Receptor Agonists and Weight Loss: A Critical Review of Mechanisms
Obesity Reviews, EarlyView.ABSTRACT GLP‐1 receptor agonist medications have the potential to promote marked weight loss, but maximal and sustained benefit may be compromised by poor compliance and cessation of use. Development of next‐generation medications that address current obstacles to effective use and development of effective adjunct treatments will benefit from better ...
Giorgia Rutigliani +8 more
wiley +1 more source
Role of sulfate ester in influencing biologic activity of cholecystokinin-related peptides [PDF]
, 1987 In dispersed acini from guinea pig, mouse, or rat pancreas cholecystokinin-(27-33) is a full agonist, and removing the sulfate ester from the tyrosine residue in position 27 caused a 100- to 300-fold decrease in potency with no change in efficacy.
R. T. Jensen, R. Vinayek, J. D. Gardner
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Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction
Obesity Reviews, EarlyView.Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey +7 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Benefits of performing physical exercise at moderate altitude. At moderate altitude, increased resting metabolic rate and physical exertion promote physical fitness and exercise tolerance, whereas hypoxia suppresses appetite and elicits adaptations that increase tissue O2 delivery while augmenting O2‐independent ATP production ...
Robert T. Mallet +6 more
wiley +1 more source
Cholecystokinin-induced desensitization of enzyme secretion in dispersed acini from guinea pig pancreas [PDF]
, 1980 Incubating dispersed acini from guinea pig pancreas with cholecystokinin and then washing the cells to remove cholecystokinin reduced the subsequent stimulation of amylase secretion caused by pancreatic secretagogues, whose actions are mediated by ...
S. Abdelmoumene, J. D. Gardner
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Improving Hepatobiliary Imaging as a Physiologic Test with Superior Clinical Outcomes
World Journal of Nuclear Medicine, 2020 This study aims at prospectively evaluating the difference in the effect of cholecystokinin (CCK) and half-and-half milk (HHM) administered in the same patient on gallbladder contractility and correlation with clinical outcomes.
Isis Gayed +6 more
doaj +1 more source
Comprehensive Physiology, Volume 16, Issue 4, August 2026.Selective purification of heart‐specific spinal and vagal sensory neurons by retrograde labeling and FACS purification showed enhanced spontaneous, optogenetic, and chemically stimulated Ca2+ activity. Transcriptomic profiling identified distinct ion channel and GPCR signatures in heart‐specific sensory neurons.
T. Akgul Caglar +8 more
wiley +1 more source
Cholecystokinin stimulates aldosterone secretion from dispersed rat zona glomerulosa cells, acting through cholecystokinin receptors 1 and 2 coupled with the adenylate cyclase-dependent cascade [PDF]
, 2001 Cholecystokinin is a regulatory peptide, that acts through two subtypes of receptors, 1 and 2. RT-PCR demonstrated the expression of both cholecystokinin receptors 1 and 2 genes in the zona glomerulosa, but not the zona fasciculata-reticularis, of rat ...
TORTORELLA, CINZIA +5 more
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Cholecystokinin receptor antagonism of stimulated pancreatic and gastric secretion [PDF]
, 1989 The effects of cholecystokinin receptor antagonist, dipentyl-3,4-dichloroproglumide (DDP), on stimulated pancreatic and gastric secretion were studied in the rat.
Debas, Haile T., Mulholland, Michael W.
core +1 more source