Results 91 to 100 of about 18,704 (213)

Gallbladder‐Related Adverse Events With Semaglutide 2.4 mg: Pooled Analysis of Placebo‐Controlled STEP Trials

Diabetes, Obesity and Metabolism, EarlyView.
Mika Ukkonen, Antti Kivivuori, Peter Starckjohann, Pekka Lammi, Anna Junttila, Valtteri Panula   +5 more
wiley   +1 more source

Myocardial Lipid Metabolism Imbalance: The Pathological Core and Novel Diagnostic‐Therapeutic Directions of Cardiovascular Diseases

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
In cardiac cells, Plin5/AMPK regulate lipid homeostasis; excess CD36‐mediated uptake drives lipotoxicity, mitochondrial dysfunction, and CVDs (e.g., heart failure). Biomarkers (ApoB/ApoA‐1) and therapies (SGLT2 inhibitors) target this cascade. ABSTRACT Cardiac lipid metabolism is fundamental to myocardial energy homeostasis, with fatty acid oxidation ...
Peiyun Xie, Qun Zeng, Hongrui Wang, Meihua She   +3 more
wiley   +1 more source

Thymosin Beta 4 Is Involved in the Development of Electroacupuncture Tolerance

Frontiers in Cellular Neuroscience, 2019
Background: Electroacupuncture (EA) tolerance, a negative therapeutic effect, is a gradual decline in antinociception because of its repeated or prolonged use.
Juan Wan, Yi Ding, Sha Nan, Qiulin Zhang, Jinrui Sun, Chuanguang Suo, Mingxing Ding   +6 more
doaj   +1 more source

Inhibition of peripheral CB1 receptors modulates food intake and metabolic efficiency in obesity independently of the gut–brain vagal axis

British Journal of Pharmacology, Volume 183, Issue 16, Page 4953-4968, August 2026.
Background and Purpose Obesity involves profound disruptions in neuronal circuits, neuroendocrine communication and the endocannabinoid system. While global blockade of cannabinoid CB1 receptors improves metabolism, its clinical use is limited by neuropsychiatric side effects.
Oriane Onimus, Camille de Almeida, Benoit Bertrand, Julien Castel, Nejmeh Mashhour, Anthony Ansoult, Serge Luquet, Giuseppe Gangarossa   +7 more
wiley   +1 more source

Effects of Glucagon‐Like Peptide‐1 Receptor Agonists (Mono and Combination Therapy) on Energy Expenditure: A Scoping Review

Obesity Reviews, Volume 27, Issue 8, August 2026.
ABSTRACT Introduction Weight loss results in reduced energy expenditure (EE) due to body composition alterations (e.g., fat‐free mass and fat mass losses) and mass‐independent adaptations in EE (e.g., hormones). Glucagon‐like peptide‐1 receptor agonists (GLP‐1RA) are indicated for obesity management; however, their effects on EE remain unclear ...
Flavio T. Vieira, ZhiDi Deng, Manfred J. Muller, Giovanna G. L. Bergamasco, Sarah Cawsey, Melania Manco, Steven B. Heymsfield, Carla M. Prado, Andrea M. Haqq   +8 more
wiley   +1 more source

Peripheral CCK-A and CCK-B receptors mediate stimulation of gastric pepsinogen and acid secretion following intracerebroventricular injection of cholecystokinin-8-sulfate [PDF]

, 1999
BACKGROUND: Peptides of cholecystokinin family regulate various physiological actions by acting at level of central nervous system. AIMS: To: 1) investigate possible influence of central cholecystokinin pathways on gastric pepsinogen and acid ...
CARIGNANI D., COLUCCI R., LAZZERI, GLORIA, BASCHIERA F., TOGNETTI M., BLANDIZZI, CORRADO, PLACANICA, GIORGIO, DEL TACCA, MARIO   +7 more
core   +2 more sources

Tumor-specific targeting of a mitochondrial Kv1.3 channel inhibitor through conjugation to gastrin/cholecystokinin B receptor ligand strongly reduces pancreatic ductal adenocarcinoma in orthotopic models

Pharmacological Research
Pancreatic ductal adenocarcinoma (PDAC) is a highly chemoresistant and immunoresistant tumor with an overall five-year survival rate of less than 10 %.
Sofia Parrasia, Carlotta Paoli, Tatiana Varanita, Valentina Brillo, Mostafa A.L. Abdel-Salam, Alberto Ongaro, Claudia Honisch, Beatrice Angi, Magdalena Bachmann, Filippo Bergamin, Vincenzo Corbo, Elena Fiorini, Andrea Rossa, Giovanna Bossio, Erich Gulbins, Alessandro Carrer, Mario Zoratti, Andrea Mattarei, Paolo Ruzza, Lucia Biasutto, Ildiko Szabo   +20 more
doaj   +1 more source

Bovine gallbladder muscularis: source of a myogenic receptor for cholecystokinin [PDF]

, 1988
Despite being a classic target for the gastrointestinal peptide hormone, cholecystokinin (CCK), the gallbladder CCK receptor is not well characterized.
B. Schjoldager, M. J. Shaw, P. F. Schmalz, J. Szurszewski, S. P. Powers, L. J. Miller   +5 more
core   +1 more source

Islets from human donors with higher but not lower hemoglobin A1c levels respond to gastrin treatment in vitro.

PLoS ONE, 2019
Gastrin is a peptide hormone, which in combination with other factors such as TGFα, EGF or GLP-1, is capable of increasing beta cell mass and lowering blood glucose levels in adult diabetic mice.
Ayelet Lenz, Gal Lenz, Hsun Teresa Ku, Kevin Ferreri, Fouad Kandeel   +4 more
doaj   +1 more source

Biochemical pharmacology of the positive allosteric modulation of the GABAb receptor "in Vitro" and "in Vivo" [PDF]

, 2007
Allosteric modulators of G-protein coupled receptors (GPCRs) interact with binding sites on the receptor molecule that are topographically distinct from the classic orthosteric site.
Gjoni, Tina
core   +1 more source