Results 101 to 110 of about 18,704 (213)

Cholecystokinin facilitates the formation of long-term heterosynaptic plasticity in the distal subiculum

Communications Biology
It has been well established that Cornu Ammonis-(CA1) and subiculum (SUB) serve as the major output components of the entorhinal-hippocampal circuitry.
Fengwen Huang, Abdul Baset, Stephen Temitayo Bello, Xi Chen, Jufang He   +4 more
doaj   +1 more source

Z-360, a novel therapeutic agent for pancreatic cancer, prevents up-regulation of ephrin B1 gene expression and phosphorylation of NR2B via suppression of interleukin-1 β production in a cancer-induced pain model in mice

Molecular Pain, 2010
Background Z-360 is an orally active cholecystokinin-2 (CCK2)/gastrin receptor antagonist currently under development as a therapeutic drug for pancreatic cancer.
Hori Yuko, Hamano Hiroki, Yoshinaga Koji, Kobayashi Nobuyoshi, Seto Koichi, Kato Hiroki, Orikawa Yuki, Meyer Tim, Takei Mineo   +8 more
doaj   +1 more source

Gastric phenotypic abnormality in cholecystokinin 2 receptor null mice [PDF]

, 2002
Gastrin, released from antral G-cells, plays an important role in the regulation of gastric acid secretion and is trophic for the stomach, The cholecystokinin type 2 (CCK)(2) receptor (previously referred to as CCK-B/gastrin receptors) is expressed in ...
Zhao, CM, Jens F. Rehfeld, Rolf Håkanson, Chun‐Mei Zhao, Chen, D, Håkanson, Rolf,, Håkanson, Rolf, Rehfeld, JF, Duan Chen, Lund University.   +9 more
core   +1 more source

The cholecystokinin-B receptor antagonist CI-988 failed to affect CCK-4 induced symptoms in panic disorder patients [PDF]

, 1997
The effects of the cholecystokinin-B (CCK-B) receptor antagonist CI-988 on symptoms elicited by the cholecystokinin tetrapeptide (CCK4) were studied in DSM-IIIR patients with panic disorder.
Slaap, B, vanEsRadhakishun, F, vanMegen, HJGM, Westenberg, HGM, denBoer, JA, Pande, AC   +5 more
core   +2 more sources

Paving the Way for CCK2R-Targeted Peptide Receptor Radionuclide Therapy with [¹⁷⁷Lu]Lu-DOTA-MGS5 in Patients with Small Cell Lung Cancer

Pharmaceutics
Background/Objectives: Peptide receptor radionuclide therapy (PRRT) is an established treatment for neuroendocrine tumors (NETs), enabling targeted radiation delivery via radiolabeled peptides.
Taraneh Sadat Zavvar, Giulia Santo, Leonhard Gruber, Ariane Kronthaler, Judith Hagenbuchner, Ira Skvortsova, Inken Piro, Katja Steiger, Vladan Martinovic, Danijela Minasch, Judith Löffler-Ragg, Gianpaolo di Santo, Irene J. Virgolini, Elisabeth von Guggenberg   +13 more
doaj   +1 more source

Rapid Generation and Molecular Docking Analysis of Single-Chain Fragment Variable (scFv) Antibody Selected by Ribosome Display Targeting Cholecystokinin B Receptor (CCK-BR) for Reduction of Chronic Neuropathic Pain. [PDF]

Int J Mol Sci, 2023
Kunamneni A, Montera MA, Durvasula R, Alles SRA, Goyal S, Westlund KN.   +5 more
europepmc   +1 more source

Cholecystokinin modulates age-dependent thalamocortical neuroplasticity

eLife
The thalamocortical pathways exhibit neuroplasticity not only during the critical period but also in adulthood. In this study, we investigated how cholecystokinin (CCK) modulates age-dependent thalamocortical plasticity.
Xiao Li, Jingyu Feng, Xiaohan Hu, Peipei Zhou, Tao Chen, Xuejiao Zheng, Peter Jendrichovsky, Xue Wang, Mengying Chen, Hao Li, Xi Chen, Dingxuan Zeng, Mengfan Zhang, Zhoujian Xiao, Ling He, Stephen Temitayo Bello, Jufang He   +16 more
doaj   +1 more source

Cholecystokinin type B receptor-mediated inhibition of A-type K+ channels enhances sensory neuronal excitability through the phosphatidylinositol 3-kinase and c-Src-dependent JNK pathway

Cell Communication and Signaling, 2019
Background Cholecystokinin (CCK) is implicated in the regulation of nociceptive sensitivity of primary afferent neurons. Nevertheless, the underlying cellular and molecular mechanisms remain unknown.
Shumin Yu, Yuan Zhang, Xianyang Zhao, Zhigang Chang, Yuan Wei, Yufang Sun, Dongsheng Jiang, Xinghong Jiang, Jin Tao   +8 more
doaj   +1 more source

Low serum gastrin associated with ER+ breast cancer development via inactivation of CCKBR/ERK/P65 signaling

BMC Cancer, 2018
Background Gastrin is an important gastrointestinal hormone produced primarily by G-cells in the antrum of the stomach. It normally regulates gastric acid secretion and is implicated in a number of human disease states, but how its function affects ...
Li-Li Meng, Jing-Long Wang, Shu-Ping Xu, Li-Dong Zu, Zhao-Wen Yan, Jian-Bing Zhang, Ya-Qin Han, Guo-Hui Fu   +7 more
doaj   +1 more source

Intestinal Gastrin/CCKBR (Cholecystokinin B Receptor) Ameliorates Salt-Sensitive Hypertension by Inhibiting Intestinal Na⁺/H⁺ Exchanger 3 Activity Through a PKC (Protein Kinase C)-Mediated NHERF1 and NHERF2 Pathway. [PDF]

Hypertension, 2022
Jiang X, Liu Y, Zhang XY, Liu X, Liu X, Wu X, Jose PA, Duan S, Xu FJ, Yang Z.   +9 more
europepmc   +1 more source