Results 171 to 180 of about 18,704 (213)

On the distribution of cholecystokinin B receptors in monkey brain

Brain Research, 1996
In view of recent evidence for a role for the B subtype of cholecystokinin (CCKB) receptor in panic and anxiety, the distribution of CCKB receptors in the forebrain of a Rhesus macaca monkey was examined by receptor autoradiography employing [125I]D-Tyr25(Nleu28,31)-CCK25-33S. CCKB receptors were widely and topographically distributed in cortex.
L D, Mercer, P M, Beart, M K, Horne, D I, Finkelstein, P, Carrive, G, Paxinos   +5 more
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Characterization of Cholecystokinin Receptors and Messenger RNA Expression in Rat Pancreas: Evidence for Expression of Cholecystokinin-A Receptors but Not Cholecystokinin-B (Gastrin) Receptors

Journal of Surgical Research, 1995
It has been previously demonstrated that guinea pig pancreas possesses both cholecystokinin-A (CCK-A) receptors and CCK-B (gastrin) receptors. In contrast to guinea pig pancreas, it is not known whether CCK receptors in rat pancreas are CCK-A receptors, CCK-B (gastrin) receptors, or both.
W, Zhou, S P, Povoski, R H, Bell
openaire   +2 more sources

Characterization of cloned human cholecystokinin-B receptor as a gastrin receptor

Biochemical Pharmacology, 1994
The cholecystokinin (CCK)-B receptor cloned from human brain was characterized as a gastrin receptor by using heterologous expression systems of COS-7 cells and Xenopus oocytes. 125I-gastrin binding to human CCK-B receptor expressed in COS-7 was time-dependent, saturable and also specific, as well as 125-I-CCK-8.
A, Miyake, S, Mochizuki, H, Kawashima
openaire   +2 more sources

Ligands for Cholecystokinin A and Cholecystokinin B/Gastrin Receptors

1991
Publisher Summary This chapter describes the radioligand binding assay methods used to identify and characterize the interaction of agents with the cholecystokinin-A (CCK-A) and CCK-B/gastrin receptor subtypes. The chapter also discusses the biochemical and pharmacological properties of nonpeptide CCK-A and CCK-B/gastrin antagonists, and their ...
Raymond S.L. Chang, Victor J. Lotti
openaire   +1 more source

The role of the ‘central’ cholecystokinin-B receptor in panic disorder

Acta Neuropsychiatrica, 1996
SummaryResearch investigating the neurobiological underpinnings of anxiety disorder have mainly been focused on dysfunction of the GABA, noradrenergic and serotonergic (5-HT) neuronal systems. Just recently, in both animal and human studies, evidence has been found for a possible role of the cholecystokinin (CCK) neuronal system in the pathogenesis of ...
Van Megen, H J G M, Westenberg, H G M, Den Boer, J A   +2 more
openaire   +3 more sources

Localization of cholecystokinin A and cholecystokinin B/ gastrin receptors in the canine upper gastrointestinal tract

Gastroenterology, 1994
Cholecystokinin (CCK) is a neuropeptide that exerts numerous effects in the gut. To determine the sites of action of CCK, the distribution and properties of CCK receptor subtypes were studied.CCK receptors were localized by autoradiographic analysis of 125I-CCK binding to frozen sections of the canine upper gastrointestinal tract.In the cardiac and ...
C R, Mantyh, T N, Pappas, S R, Vigna
openaire   +2 more sources

Cholecystokinin A and B Receptor mRNA Expression in Human Pancreas

Pancreas, 1999
Little information is available on the expression of cholecystokinin (CCK) receptors in the human pancreas, especially in the developing pancreas. We evaluated expression patterns for the CCK receptors in human pancreas at three different ages: fetus, infant, and adult.
I, Nishimori, M, Kamakura, K, Fujikawa-Adachi, M, Nojima, S, Onishi, M A, Hollingsworth, A, Harris   +6 more
openaire   +2 more sources

Caerulein may potentiate morphine-induced antinociception by cholecystokinin-A and/or cholecystokinin-B receptor mechanisms

General Pharmacology: The Vascular System, 1997
1. The effects of a cholecystokinin agonist and antagonist on morphine antinociception in the tail-flick test have been evaluated. 2. The administration of different doses of caerulein (0.01, 0.05 and 0.1 mg/kg) 30 min prior to morphine (1.5, 3 and 6 mg/kg) increased the antinociception induced by morphine in mice. 3.
M, Rezayat, S, Oreizi, M R, Zarrindast
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Overexpression of Cholecystokinin-B/ Gastrin Receptor Gene in the Stomach of Naturally Occurring Cholecystokinin-A Receptor Gene Knockout Rats

Digestion, 1998
We examined the cholecystokinin (CCK)-B/gastrin receptor, H⁺/K⁺-ATPase and somatostatin gene expression, the histology and immunohistochemistry of gastrin and somatostatin of the stomach, plasma gastrin levels, and gastric acid secretion in naturally occurring CCK-A receptor gene knockout (Otsuka Long-Evans
K, Miyasaka, S, Kanai, M, Ohta, A, Jimi, A, Kono, A, Funakoshi   +5 more
openaire   +2 more sources

Identification and characterization of various cholecystokinin B receptor mRNA forms in rat brain tissue and determination of the cholecystokinin B receptor gene structure

Neuropeptides, 1994
Abstract: Using the powerful method of DNA amplification, we have been able to isolate several cholecystokinin B (CCKB) receptor (CCKB‐R) mRNA forms from rat brain tissue, allowing the detection of a truncated mRNA species and the determination of the CCKB‐R gene structure.
Jagerschmidt, A., Popovici, T., O'Donohue, Michael, Roques, B.   +3 more
openaire   +3 more sources