Results 181 to 190 of about 18,704 (213)

Cholecystokinin-B/gastrin receptor-targeting peptides for staging and therapy of medullary thyroid cancer and other cholecystokinin-B receptor-expressing malignancies

Seminars in Nuclear Medicine, 2002
The high sensitivity of the pentagastrin stimulation test in detecting primary or metastatic medullary thyroid cancer (MTC) suggests a widespread expression of the corresponding receptor type on human MTC. Indeed, autoradiographic studies demonstrated cholecystokinin (CCK)-B/gastrin receptors not only in more than 90% of MTCs, but also in a high ...
Thomas M, Behr, Martin P, Béhé
openaire   +2 more sources

A water soluble benzazepine cholecystokinin-B receptor antagonist

Bioorganic & Medicinal Chemistry Letters, 1995
Abstract A series of 5-substituted-3-ureidobenzazepin-2-ones bearing ioizable functionality was synthesized as potential cholecystokinin-B (CCK-B) receptor antagonists. SAR of this series of compounds demonstrated the optimal combination of a carboxylic acid and 5-cyclohexyl group, providing the high affinity (CCK-B IC 50 = 0.10 nM), water soluble ...
John A. Lowe, Susan E. Drozda, Stafford McLean, Dianne K. Bryce, Rosemary T. Crawford, Stevin Zorn, Jean Morrone, Troy A. Appleton, Franco Lombardo   +8 more
openaire   +1 more source

Cholecystokinin CCKB receptor mRNA isoforms

NeuroReport, 1999
In the light of earlier findings of reduced cholecystokinin (CCK) peptide and CCK mRNA levels in the cerebral cortex, we have used in situ hybridization to examine possible regulation of mRNAs coding for two isoforms of the CCK(B) receptor in frontal cortex (Brodmann's area 10) of schizophrenic patients.
O, Zachrisson, J, de Belleroche, K R, Wendt, S, Hirsch, N, Lindefors   +4 more
openaire   +2 more sources

Cardiovascular Effects of Cholecystokinin-4 Are Mediated By the Cholecystokinin-B Receptor Subtype In the Conscious Guinea Pig and Dog

The Journal of Pharmacology and Experimental Therapeutics, 1997
Panicogenic effects in humans of the selective cholecystokinin (CCK(B)) receptor agonist, cholecystokinin tetrapeptide (CCK4), have been reported to correlate with increases in heart rate (HR) and mean arterial pressure (MAP). Previous investigators have demonstrated that the nonselective CCK(A) and CCK(B) receptor agonist, sulfated cholecystokinin ...
A A, Fossa, M J, DePasquale, J, Morrone, S H, Zorn, D, Bryce, J A, Lowe, S, McLean   +6 more
openaire   +2 more sources

Association studies of the cholecystokinin B receptor and A2a adenosine receptor genes in panic disorder

Journal of Neural Transmission, 2001
Several lines of evidence implicate the cholecystokinin B receptor (CCKBR) and the A2a adenosine receptor (A2aAR) in the etiology of panic disorder. To determine the roles each of these receptors may play in panic disorder, we have performed a mutation screen on the CCKBR gene using single strand conformation polymorphism (SSCP) analysis and sequencing.
K, Yamada, E, Hattori, M, Shimizu, A, Sugaya, H, Shibuya, T, Yoshikawa   +5 more
openaire   +2 more sources

Cholecystokinin-B receptor antagonists attenuate morphine dependence and withdrawal in rats

NeuroReport, 2000
The possible effect of a cholecystokinin-8 agonist (caerulein) and antagonists (MK-329 and L365,260) on the development of morphine dependence and withdrawal were investigated in rats. Caerulein treatment (0.01 and 0.1 mg/kg) increased the incidence of naloxone-induced withdrawal syndromes and delayed the extinction of morphine-conditioned place ...
L, Lu, M, Huang, Z, Liu, L, Ma
openaire   +2 more sources

Role of cholecystokinin type B receptors in ultrasound induced behavior in rats

Peptides, 1999
The cholecystokinin-tetrapeptide (CCK-4) can induce panic attacks in humans. The present study investigates the effects of CCK-4 and the CCK-B receptor antagonist L-365.260 on ultrasound induced defense behavior in the rat that may model the unconditioned aspects of panic behavior in man.
M, Voits, S R, Beckett, C A, Marsden, H, Fink   +3 more
openaire   +2 more sources

Cholecystokinin-Induced Antinociception is Not Blocked by CCK-A or CCK-B Receptor Antagonists

Peptides, 1997
To determine the relative importance of CCK-A, CCK-B, and opioid receptors in mediating the antinociceptive actions of cholecystokinin, we evaluated the actions of selective agonists and antagonists in the mouse hot plate assay. The agonists used were CCK (1-30 nmol i.c.v.), a CCK-A receptor agonist (SNF9019; 0.3-10 nmol i.c.v.), and a CCK-B receptor ...
C L, Williams, G C, Rosenfeld, T F, Burks   +2 more
openaire   +2 more sources

Quinazolinone cholecystokinin-B receptor ligands

Journal of Medicinal Chemistry, 1991
M J, Yu, K J, Thrasher, J R, McCowan, N R, Mason, L G, Mendelsohn   +4 more
openaire   +2 more sources

Cholecystokinin type A receptor

AfCS-Nature Molecule Pages, 2006
openaire   +1 more source