Results 111 to 120 of about 78,581 (298)

Vaccine Candidates Designed to Prevent Enterotoxigenic Escherichia coli Diarrhoea: A Scoping Review of Clinical Trials Evaluating Vaccine Candidates in Development

Tropical Medicine &International Health, EarlyView.
ABSTRACT Objectives The primary objectives of this study are to (1) summarise the current landscape of ETEC vaccine development by describing, characterising and comparing ETEC vaccine candidates in clinical development, (2) assess key characteristics of the phases 1, 2 and 3 clinical trials that have been designed to evaluate ETEC vaccines in ...
Vaidehi Nafade, Naheemot O. Sule, Yang Zhang, Angelina Sassi, Nicole E. Basta   +4 more
wiley   +1 more source

Fmr1 knockout disrupts multiple intrinsic properties via reduced HCN channel activity in mediodorsal thalamocortical neurons

Experimental Physiology, EarlyView.
Abstract The neurodevelopmental disorder fragile X syndrome (FXS) results from hypermethylation of the FMR1 gene, which prevents production of the FMRP protein. FMRP modulates the expression and function of a variety of proteins, including voltage‐gated ion channels, such as hyperpolarization‐activated and cyclic nucleotide‐gated (HCN) channels, which ...
Gregory J. Ordemann, Polina Lyuboslavsky, Alena Kizimenko, Audrey C. Brumback   +3 more
wiley   +1 more source

In Vitro Selection of a Single-Stranded DNA Molecular Recognition Element against Clostridium difficile Toxin B and Sensitive Detection in Human Fecal Matter

Journal of Nucleic Acids, 2015
Toxin B is one of the major virulence factors of Clostridium difficile, a bacterium that is responsible for a significant number of diarrhea cases in acute care settings. Due to the prevalence of C. difficile induced diarrhea, rapid and correct diagnosis
Ka Lok Hong, Eamonn Maher, Ryan M. Williams, Letha J. Sooter   +3 more
doaj   +1 more source

Kinetics and cellular site of glycolipid loading control [PDF]

, 2009
CD1d-restricted natural killer T cells (NKT cells) possess a wide range of effector and regulatory activities that are related to their ability to secrete both T helper 1 (Th1) cell- and Th2 cell-type cytokines.
Arora, Pooja, Baena, Andres, Baine, Ian, Bricard, Gabriel, Goldberg, Michael F., Im, Jin S., Jerud, Elliot S., Molano, Alberto, Ndonye, Rachel M., Venkataswamy, Manjunatha M., Yu, Karl O.A.   +10 more
core  

GABAB receptor‐mediated modulation of sensory neuron excitability: Roles of CaV2.2, G‐protein‐coupled inwardly rectifying potassium (GIRK) channels, and hyperpolarisation‐activated cyclic nucleotide‐gated (HCN) channels in human and mouse nociception

Experimental Physiology, EarlyView.
Abstract Chronic visceral pain is a key symptom of irritable bowel syndrome. Modulation of voltage‐gated calcium and potassium channels by G protein‐coupled receptors plays a key role in dampening nociceptive transmission. Both baclofen and the analgesic peptide α‐conotoxin Vc1.1 activate GABAB receptors (GABABR), resulting in inhibition of CaV2.2 and ...
Mariana Brizuela, Anuja R. Bony, Sonia Garcia‐Caraballo, David J. Adams, Stuart M. Brierley   +4 more
wiley   +1 more source

PENGARUH EKSTRAK DIKLOROMETAN JAHE (Zingiber officinale Roscoe) TERHADAP PENGIKATAN TOKSIN KOLERA B-subunit CONJUGASI (FITC) PADA RECEPTOR SEL HIBRIDOMA LV DAN CACO-2 [Effect of Ginger (Zingiber officinale Roscoe) Dichloromethane Extract on Inhibition of Cholera Toxin B-subunit Conjugated FITC Binding to Receptor on LV Hibridome and Caco-2 Cells]

Jurnal Teknologi dan Industri Pangan, 2003
Cholera toxin is main factor that responsibility of watery diarrhea. The objectives of this investigation was to study the effect of ginger extract (GDE) in blocking cholera toxin binding to receptors of LV hybridome and Caco-2 cells.Analysis of toxin
Radiati, L.E 1), Nabet, P , Franck, P 2), Nabet B 2), Capiaumont, J 2), Fardiaz, D 3), Zakaria, R.F 3), I. Sudirman 4), Hariyadi, R.D 3)   +7 more
doaj  

Targeting Multiple Binding Sites on Cholera Toxin B with Glycomimetic Polymers Promotes the Formation of Protein–Polymer Aggregates

, 2020
Gyusaang Youn, Jakob Cervin, Xiaoxi Yu, Surita R. Bhatia, Ulf Yrlid, Nicole S. Sampson   +5 more
openalex   +2 more sources

Identification of GTP‐Binding Proteins by ADP‐Ribosylation in the Presence of Cholera Toxin, Pertussis Toxin and Botulinum Toxin D in Plasma Membrane Isolated from Eggs and Embryos of Sea Urchin [PDF]

, 1992
Yasuyuki Kamata, Shigehisa Furuya, Kaori Takei‐Mikami, Akiko Fujiwara, Ikuo Yasumasu   +4 more
openalex   +1 more source

Drinking Water Quality Regulations: A Contrast Between Germany and Latin America

Environmental Quality Management, Volume 35, Issue 3, Spring 2026.
ABSTRACT This article investigates the differences among drinking water quality standards adopted in Latin American countries, Mexico, Cuba, and the European Union, considering the growing challenge of ensuring safe drinking water in a context marked by environmental pressures, climate change, and the occurrence of emerging contaminants. The study aims
Eduardo Saldanha Vogelmann, Juliana Prevedello, Gizachew Ayalew Tiruneh   +2 more
wiley   +1 more source

Cholera Toxin Production and Localization in Vesicles of Vibrio cholerae El Tor Genovariants

Проблемы особо опасных инфекций
The aim was to assess the level of toxin production in Vibrio cholerae El Tor genovariants and to determine the localization of cholera toxin in vesicles.Materials and methods. The work is performed on typical strains and genovariants of V.
L. P. Alekseeva, O. A. Yakusheva, V. V. Evdokimova, M. G. Meloyan, V. P. Zyuzina   +4 more
doaj   +1 more source