Results 121 to 130 of about 78,581 (298)

Manipulation of the Unfolded Protein Response by Intracellular Bacterial Pathogens: Mechanisms of ER Hijacking and Therapeutic Implications

open access: yesThe FASEB Journal, Volume 40, Issue 2, 31 January 2026.
This review illustrates how intracellular bacterial pathogens—such as Brucella, Mycobacterium tuberculosis, and Legionella—secrete effector proteins that specifically target the IRE1α, PERK, and ATF6 branches of the unfolded protein response (UPR) to hijack ER stress signaling.
Enhui Dai   +5 more
wiley   +1 more source

Molecular Dynamics Simulation of Cholera Toxin A-1 Polypeptide

open access: yesOpen Chemistry, 2016
A molecular dynamics (MD) simulation study of the enzymatic portion of cholera toxin; cholera toxin A-1 polypeptide (CTA1) was performed at 283, 310 and 323 K.
Badshah Syed Lal   +2 more
doaj   +1 more source

Integrin‐Piezo1 Axis Drives ECM Remodeling and Invasion of 3D Breast Epithelium

open access: yesAdvanced Science, Volume 13, Issue 5, 27 January 2026.
Mechanical stiffening of the extracellular matrix around mature mammary acini induces sequential remodeling phases. An early response disrupts the basement membrane and promotes fibronectin secretion, followed by delayed invasion with matrix reorganization and proliferation.
Kabilan Sakthivel   +8 more
wiley   +1 more source

Gz, a guanine nucleotide-binding protein with unique biochemical properties [PDF]

open access: yes, 1990
Cloning of a complementary DNA (cDNA) for Gz alpha, a newly appreciated member of the family of guanine nucleotide-binding regulatory proteins (G proteins), has allowed preparation of specific antisera to identify the protein in tissues and to assay it ...
Casey, Patrick J.   +3 more
core  

[Cholera toxin as Vibrio cholera superantigen].

open access: yesZhurnal mikrobiologii, epidemiologii i immunobiologii, 2002
Experimental data confirming our earlier suggestion, that cholerae toxin (CT) possesses superantigen (SA) properties are presented. When used in very small doses, CT has been found to induce polyclonal activation of T lymphocytes, essentially exceeding that observed in classical T mitogens characteristic of SA. CT, in contrast to mitogens and similarly
G I, Vasil'eva   +3 more
openaire   +1 more source

Designer Solid Self‐Emulsifying Nanovaccines Enable Dual Modulation of Dendritic Cells and T Cells for Potent Antitumor Immunity

open access: yesAdvanced Science, Volume 13, Issue 5, 27 January 2026.
A solid self‐emulsifying (SSE) platform is loaded with peptide antigens and CpG to form the SSE vaccine. An ApoE‐enriched corona promotes dendritic cell internalization, enabling antigen presentation and T cell activation. Squalene from the SSE also sensitizes T cells by promoting lipid raft formation.
Xueying Shen   +8 more
wiley   +1 more source

In Vitro Expression Of The Ctxb Toxin Gene Towards The Development Of A Dna Vaccine Against Cholera [PDF]

open access: yes, 2001
The complete eradication of cholera is an unachievable goal because it is now firmly established that there are environmental reservoirs for Vibrio cholerae.
Abdullah, Sharilnizam
core  

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