Results 31 to 40 of about 41,359 (179)

Caco-2/HT29-MTX co-cultured cells as a model for studying physiological properties and toxin-induced effects on intestinal cells.

PLoS ONE, 2021
Infectious gastrointestinal diseases are frequently caused by toxins secreted by pathogens which may impair physiological functions of the intestines, for instance by cholera toxin or by heat-labile enterotoxin.
Pascal Hoffmann, Marion Burmester, Marion Langeheine, Ralph Brehm, Michael T Empl, Bettina Seeger, Gerhard Breves   +6 more
doaj   +1 more source

AKAP1 Protects Retinal Ganglion Cells and Preserves Vision by Improving Mitochondrial and Synaptic Health in Glaucomatous Neurodegeneration

Advanced Science, EarlyView.
Intravitreal AAV2‐mediated AKAP1 restoration enhances mitochondrial fusion and biogenesis, improves bioenergetic capacity, and preserves mitochondrial integrity in glaucomatous RGCs. AKAP1 stabilizes presynaptic structure, maintaining synaptic protein expression, and limiting complement‐associated neuroinflammation.
Tonking Bastola, Keun‐Young Kim, Ziyao Shen, Guy A. Perkins, Muna Poudel, Yoonjin Lim, Hyejeong Choi, Soo‐Ho Choi, Mark H. Ellisman, Robert N. Weinreb, Won‐Kyu Ju   +10 more
wiley   +1 more source

Targeting Mitochondrial Redox Signaling Promotes Neuroregeneration and Functional Recovery in a Multiple Sclerosis Model

Advanced Science, EarlyView.
Modulation of mitochondrial redox signaling by furapyrrodole activates CYB5R3 and suppresses Notch signaling, unlocking the regenerative potential of endogenous neural progenitor cells. This approach promotes neurogenesis, oligodendrogenesis, and remyelination, thereby improving neuronal function in a mouse model of multiple sclerosis and identifying ...
Yuki Narushima, Joshua Saylor, Shun Saito, Jinyan Zhou, Haruka Kawano, Shehata Anwar, Haruki Oba, Rachel Huezo, Miyu Okano, Haruki Matsuda, Makoto Kawatani, Kaori Honda, Hiroyuki Osada, Yuta Kikuchi, Masahito Ohue, Masami Ishibashi, Takayoshi Arai, Makoto Inoue, Midori A. Arai   +18 more
wiley   +1 more source

Production of Chicken Egg Yolk Antibody (IgY) Against Recombinant Cholera Toxin B Subunit and Evaluation of Its Prophylaxis Potency in Mice [PDF]

Iranian Journal of Immunology, 2018
Background: Cholera toxin (CT), responsible for the harmful effects of cholera infection, is made up of one A subunit (enzymatic), and five B subunits (cell binding). The release of cholera toxin is the main reason for the debilitating loss of intestinal
Babak Barati, Firouz Ebrahimi, Shahram Nazarian   +2 more
doaj  

Integrating One Health to Mitigate the Emergence and Spread of Antimicrobial Resistance in Livestock and Aquaculture

Animal Research and One Health, EarlyView.
Antimicrobial resistance (AMR) is an escalating global threat driven by antimicrobial use in aquaculture and livestock. Resistant pathogens and genes can spread across humans, animals, and the environment through interconnected ecosystems. Using a One Health approach, this review emphasizes antimicrobial stewardship, regulatory strengthening, enhanced ...
Mir Mohammad Ali, Delower Hossain, Ridwan Olamilekan Adesola, Anum Hanif, Shamsaldeen Ibrahim Saeed, Muhammad Abdul Mannan, Anoar Jamai Masroure, Kazi Estieque Alam, Md Kamal Hossain, Sabiha Zarin Tasnim Bristi, Md Jisan Ahmed   +10 more
wiley   +1 more source

Subunit Structure of Cholera Toxin [PDF]

Journal of General Microbiology, 1973
SUMMARY Two types of subunit, with molecular weights estimated to be 28000 and 8000, were demonstrated in the cholera exo-enterotoxin by sodium dodecylsulphate polyacrylamide electrophoresis. The light (L) component but not the heavy (H) was demonstrable in the antigenically identical natural toxoid.
I, Lönnroth, J, Holmgren
openaire   +2 more sources

Antimicrobial Peptides and Peptidomimetics in Foods – A Synthetic Foray

ChemFoodChem, EarlyView.
This Review discusses AMPs in foods and their syntheses. It espouses facile methods to make them accessible and suggests their utility in the mitigation and eradication of the burgeoning maladies of antimicrobial and multidrug resistance (AMR and MDR).
Josephat U. Izunobi, Adejoke D. Osinubi, Abosede A. Badeji   +2 more
wiley   +1 more source

An Overview of Foodborne Risks in Afghanistan

Food Safety and Health, EarlyView.
ABSTRACT Foodborne diseases represent a serious yet underrecognized public health burden in Afghanistan, a country shaped by decades of conflict, weak infrastructure, and limited regulatory capacity. This article provides a comprehensive overview of major foodborne risks in the country, including microbiological hazards, chemical contaminants, and ...
Mohammad Aman Ahmadzai, Shir Mohammad Samim, Ahmadullah Zahir   +2 more
wiley   +1 more source

Sorption Properties of Polymeric Enterosorbent and Its Specific Modified Analogue in Simulated Cholera Toxin Solutions in vitro

Проблемы особо опасных инфекций, 2014
Carried out was comparative study of the sorption properties in polymeric enterosorbent - chitosan, and its specific modified analogue obtained through absorption of anti-toxin immunoglobulins onto the soluble chitosan template.
M. V. Ovchinnikova, M. N. Kireev, A. K. Nikiforov   +2 more
doaj   +1 more source

Two Different Diagnosis Methods For The detection of cholera toxin production From Vibrio cholerae isolated from different areas in Iraq

The Iraqi Journal of Veterinary Medicine, 2010
Fifty isolates of Vibrio cholerae obtained from different areas in Iraq from patients with acute secretory diarrhea were diagnosed serologically in central public health laboratory(CPHL), Two different methods were used for detection cholera toxin ...
Atheer Abdulrazzaq
doaj   +1 more source