Results 51 to 60 of about 190,106 (220)

Caco-2/HT29-MTX co-cultured cells as a model for studying physiological properties and toxin-induced effects on intestinal cells.

PLoS ONE, 2021
Infectious gastrointestinal diseases are frequently caused by toxins secreted by pathogens which may impair physiological functions of the intestines, for instance by cholera toxin or by heat-labile enterotoxin.
Pascal Hoffmann, Marion Burmester, Marion Langeheine, Ralph Brehm, Michael T Empl, Bettina Seeger, Gerhard Breves   +6 more
doaj   +1 more source

Plant Virus Immunotherapy for HPV‐Associated Oropharyngeal Squamous Cell Carcinoma

Advanced NanoBiomed Research, EarlyView.
Cowpea mosaic virus (CPMV) nanoparticles are safe and potent cancer immunotherapy candidates with strong immunomodulatory activity. CPMV activates innate immunity, which in turn drives adaptive immune responses and promotes durable, systemic antitumor effects.
Jessica Fernanda Affonso de Oliveira, Patrick Opdensteinen, Andrea Simms, Seongwon Jung, Giuliana P. Mognol, Hui Chen, Judith A. Varner, Nicole F. Steinmetz   +7 more
wiley   +1 more source

How ricin and shiga toxin reach the cytosol of target cells : retrotranslocation from the endoplasmic reticulum [PDF]

, 2012
A number of protein toxins bind at the surface of mammalian cells and after endocytosis traffic to the endoplasmic reticulum, where the toxic A chains are liberated from the holotoxin.
Lord, Mike, Spooner, Robert A.
core  

Costs of illness due to cholera, costs of immunization and cost-effectiveness of an oral cholera mass vaccination campaign in Zanzibar [PDF]

, 2012
BACKGROUND: The World Health Organization (WHO) recommends oral cholera vaccines (OCVs) as a supplementary tool to conventional prevention of cholera. Dukoral, a killed whole-cell two-dose OCV, was used in a mass vaccination campaign in 2009 in Zanzibar.
Claire-Lise Chaignat, Duintjer Tebbens Radboud J., Rita Reyburn, Weiss Mitchell G., Schaetti, C., Radboud J Duintjer Tebbens, Weiss, M. G., Rita Reyburn (130140), Khatib, A. M., Reyburn, R., Ahmed M. Khatib (130136), Mitchell G Weiss, Hutubessy Raymond, Schaetti Christian, Ahmed M Khatib, Claire-Lise Chaignat (127845), Raymond Hutubessy (130149), Ali, S. M., Khatib Ahmed M., Mitchell G. Weiss (130129), Chaignat Claire-Lise, Ali Said M., Hutubessy, R., Reyburn Rita, Christian Schaetti (130127), Chaignat, C. L., Raymond Hutubessy, Christian Schaetti, Said M Ali, Duintjer, Tebbens, Said M. Ali (130132), Radboud J. Duintjer Tebbens (130144)   +31 more
core   +1 more source

Construction of an El Tor Biovariant Vibrio cholerae Strain Capable of Type II Cholera Toxin Hyperproduction and Determining the Optimal Conditions for the Production of This Protein

Проблемы особо опасных инфекций, 2008
Introduction of Tn5-Mob (KmR) transposon into the chromosome of the toxinogenic V. cholerae strain MAK757 El Tor biovar was shown to result in the emergence of insertion mutants containing an altered genome of CTXφ prophage.
A. A. Goryaev, E. Yu. Shchelkanova, Yu. V. Lozovsky, I. V. Touchkov, N. I. Smirnova   +4 more
doaj   +1 more source

Integrating One Health to Mitigate the Emergence and Spread of Antimicrobial Resistance in Livestock and Aquaculture

Animal Research and One Health, EarlyView.
Antimicrobial resistance (AMR) is an escalating global threat driven by antimicrobial use in aquaculture and livestock. Resistant pathogens and genes can spread across humans, animals, and the environment through interconnected ecosystems. Using a One Health approach, this review emphasizes antimicrobial stewardship, regulatory strengthening, enhanced ...
Mir Mohammad Ali, Delower Hossain, Ridwan Olamilekan Adesola, Anum Hanif, Shamsaldeen Ibrahim Saeed, Muhammad Abdul Mannan, Anoar Jamai Masroure, Kazi Estieque Alam, Md Kamal Hossain, Sabiha Zarin Tasnim Bristi, Md Jisan Ahmed   +10 more
wiley   +1 more source

Mechanism of action of cholera toxin [PDF]

, 1982
Cholera "toxin binds to the outside of cells and one of its sub-units enters to activate adenylate cyclase. In the current work the nature of this action across the membrane was related to the hydrophobicities of cholera toxin and its subunits. Charge—
Ward, W.H.J
core   +3 more sources

Adaptive Immunity in Marsupials

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
Comparison of the marsupial and eutherian adaptive immune systems. ABSTRACT Marsupials diverged from eutherian mammals 125–160 million years ago. Although evolutionarily distinct, both groups of mammals can produce complex adaptive immune responses to antigens with several key differences.
Cassandra L. Jol, Hayley J. Stannard, Julie M. Old   +2 more
wiley   +1 more source

Production of Chicken Egg Yolk Antibody (IgY) Against Recombinant Cholera Toxin B Subunit and Evaluation of Its Prophylaxis Potency in Mice [PDF]

Iranian Journal of Immunology, 2018
Background: Cholera toxin (CT), responsible for the harmful effects of cholera infection, is made up of one A subunit (enzymatic), and five B subunits (cell binding). The release of cholera toxin is the main reason for the debilitating loss of intestinal
Babak Barati, Firouz Ebrahimi, Shahram Nazarian   +2 more
doaj  

Subunit Structure of Cholera Toxin [PDF]

Journal of General Microbiology, 1973
SUMMARY Two types of subunit, with molecular weights estimated to be 28000 and 8000, were demonstrated in the cholera exo-enterotoxin by sodium dodecylsulphate polyacrylamide electrophoresis. The light (L) component but not the heavy (H) was demonstrable in the antigenically identical natural toxoid.
I, Lönnroth, J, Holmgren
openaire   +2 more sources