Results 61 to 70 of about 39,371 (175)

Living Microbial Drugs

open access: yesChemistry – A European Journal, Volume 32, Issue 26, 11 July 2026.
The introduction outlines the review scope. Microbial cell factories as living drugs cover host–gut microbiota, bacteria, yeast, and other microbial systems, with comparative host advantages. Engineering strategies include synthetic circuits, quorum sensing, and memory.
Cemile Elif Özçelik   +3 more
wiley   +1 more source

Self‐Assembled Skin Equivalents with Monoclonal CRISPR/Cas9‐Modified N/TERT‐1 Keratinocytes: A Cutting‐Edge Model for Human Skin and its Diseases

open access: yesAdvanced Healthcare Materials, Volume 15, Issue 25, 3 July 2026.
Self‐assembled, scaffold‐free full‐thickness skin equivalents with monoclonal, genetically modified N/TERT‐1 keratinocytes represent a novel in vitro model of human skin and skin diseases. The model is highly robust, reproducible, physiologically relevant, and suitable for high‐throughput applications.
Marta Slaufova   +4 more
wiley   +1 more source

The Apoptotic Effects of the P300 Activator on Breast Cancer and Lung Fibroblast Cell Lines

open access: yesMiddle East Journal of Cancer, 2013
Background: P300 is an enzyme that acetylates histones during stress. It alsoacetylates several non-histone proteins, including P53 which is the most important tumorsuppressor gene. P53 plays an important role in the apoptosis of tumor cells. Hereby,this
Mohammad Reza Salahshoor   +5 more
doaj  

Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq

open access: yesAdvanced Science, Volume 13, Issue 40, 17 July 2026.
Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su   +10 more
wiley   +1 more source

THE STUDY OF LYMPHOCYTE APOPTOSIS INDUCED BY VIBRIO CHOLERAE ANTIGENS IN THE FORMATION OF IMMUNODEFICIENCY AND THE POSSIBILITY OF ITS CORRECTION

open access: yesМедицинский вестник Юга России, 2013
Purpose: To study the role of lymphocyte apoptosis induced by Vibrio cholerae microbial cells and cholera toxin in the formation of the postvaccinal apoptotic immunodeficiency, as well as the possibility of its correction with the use of immunomodulator ...
I. A. Ivanova   +9 more
doaj   +1 more source

Fibronectin1‐Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition

open access: yesAdvanced Science, Volume 13, Issue 39, 13 July 2026.
Fibronectin 1 (FN1)‐expressing subicular subpopulations encode novel object preference and selectively govern retrieval of novel object recognition (NOR) via affecting excitability of entorhinal‐projecting circuit through large conductance Ca2+‐activated potassium (BK) channel. ABSTRACT Novel object recognition (NOR), referring to the cognitive ability
Fan Fei   +15 more
wiley   +1 more source

Production and Purification of Polyclonal Antibody against Cholera Toxin

open access: yesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2015
BACKGROUND AND OBJECTIVE: Cholera is a debilitating enteric disease, caused by Vibrio cholerae. Cholera toxin is the most important virulence factor in the pathogenesis of Vibrio cholera.
Shahram Nazarian   +3 more
doaj  

Association between post-diagnostic use of cholera vaccine and risk of death in prostate cancer patients

open access: yesNature Communications, 2018
Post-diagnostic use of cholera vaccine can improve the prognosis in patients with colorectal cancer suggesting cholera toxin might have an antineoplastic effect.
Jianguang Ji   +2 more
doaj   +1 more source

Recombinant Strains Application for Simultaneous Preparation of Several Purified Cholera Vibrio Antigens

open access: yesПроблемы особо опасных инфекций, 2009
Proposed is the method for simultaneous isolation and purification of three cholera vibrio key pathogenicity factors (cholera toxin, toxin-co-regulated adhesion pili, O1 antigen Ogawa or Inaba), which are main protective antigens, from previously ...
T.L. Zakharova   +4 more
doaj   +1 more source

Posttranslational Regulation of IL-23 Production Distinguishes the Innate Immune Responses to Live Toxigenic versus Heat-Inactivated Vibrio cholerae

open access: yesmSphere, 2019
Vibrio cholerae infection provides long-lasting protective immunity, while oral, inactivated cholera vaccines (OCV) result in more-limited protection. To identify characteristics of the innate immune response that may distinguish natural V.
Ana A. Weil   +13 more
doaj   +1 more source

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