Results 41 to 50 of about 41,359 (179)
The Journal of Pathology, EarlyView.Abstract TP53 is the most frequently mutated gene in oral squamous cell carcinoma (OSCC); however, its role in promoting epithelial–mesenchymal transition (EMT) and tumour progression remains unclear, particularly within the context of intra‐tumour heterogeneity.
Rana Alaaeldin Ibrahim +9 more
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Actions of cholera toxin and the prevention and treatment of cholera [PDF]
Nature, 1981 The drastic intestinal secretion of fluid and electrolytes that is characteristic of cholera is the result of reasonably well understood cellular and biochemical actions of the toxin secreted by Vibrio cholerae. Based on this understanding it is possible to devise new techniques for the treatment and prophylaxis of cholera to complement those based on ...
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Binding of NAD+ by cholera toxin [PDF]
Biochemical Journal, 1987 1. The Km for NAD+ of cholera toxin working as an NAD+ glycohydrolase is 4 mM, and this is increased to about 50 mM in the presence of low-Mr ADP-ribose acceptors. Only molecules having both the adenine and nicotinamide moieties of NAD+ with minor alterations in the nicotinamide ring can be competitive inhibitors of this reaction. 2.
T S, Galloway, S, van Heyningen
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Orally delivered toxin–binding protein protects against diarrhoea in a murine cholera model
Nature CommunicationsThe ongoing seventh cholera pandemic, which began in 1961, poses an escalating threat to public health. There is a need for new cholera control measures, particularly ones that can be produced at low cost, for the one billion people living in cholera ...
Marcus Petersson +15 more
doaj +1 more source
Journal of Polymer Science, EarlyView.We present a microfluidic immunoadsorption platform functionalized with a layer‐by‐layer (LbL) nanofilm composed of poly(diallyldimethylammonium chloride) (PDDA) and protein extract (PE) for selective capture of peanut‐specific antibodies directly from the whole blood obtained from a peanut allergy mouse model.
Hesaneh Ahmadi +4 more
wiley +1 more source
Grape extracts inhibit multiple events in the cell biology of cholera intoxication. [PDF]
PLoS ONE, 2013 Vibrio cholerae produces cholera toxin (CT), an AB5 protein toxin that is primarily responsible for the profuse watery diarrhea of cholera. CT is secreted into the extracellular milieu, but the toxin attacks its Gsα target within the cytosol of a host ...
Srikar Reddy +7 more
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Phytotherapy Research, EarlyView.Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko +3 more
wiley +1 more source
Photolabelling of cholera toxin by NAD+ [PDF]
Biochemical Journal, 1987 When cholera toxin is incubated under u.v. light with NAD+ labelled in either the adenine or the nicotinamide moiety, radioactivity becomes covalently bound to the protein. The reaction is specific for cholera toxin, and is inhibited by excess unlabelled NAD+ or NAD analogues. Only the active A 1 chain of the toxin is labelled.
T S, Galloway +2 more
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Sustainable Development, EarlyView.ABSTRACT There have been emerging media reports on the impact of cyanide and mercury use in artisanal and small‐scale gold mining (ASGM) operations on community health, especially among pregnant and non‐pregnant women, ASGM miners, and children in rural Africa.
Francis Arthur‐Holmes +2 more
wiley +1 more source
INTERACTION OF CHOLERA TOXIN AND TOXIN DERIVATIVES WITH LYMPHOCYTES [PDF]
The Journal of Experimental Medicine, 1974 The interaction of cholera toxin and a number of toxin derivatives, containing different proportions of light and heavy toxin-composing subunits (L and H), with mouse lymphocytes was studied. Experiments with [125I]toxin showed that a single cell can rapidly, within minutes, bind up to 40,000 molecules of toxin, the association constant was estimated ...
J, Holmgren, L, Lindholm, I, Lönnroth
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