Results 11 to 20 of about 505 (164)

Experimental Assessment of the Effects of Substrate Choice on the Duration of Chemical Signals in Fecal Scent‐Marks of Free‐Ranging Iberian Wolves

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT Chemical communication, typically based on feces, urine, and glandular secretions, often deposited as substrate scent marks, plays a key role in social organization and communication among many mammals, especially carnivores. This study assesses experimentally whether the type of substrate chosen for fecal deposition and the temperature ...
Elisa Espartosa, Jose Martin, Isabel Barja   +2 more
wiley   +1 more source

Fecal Steroids as Tracers of Human Population and Waste Management Practices at the Ancient Maya City of Ucanal, Guatemala

Archaeometry, EarlyView.
ABSTRACT Geochemical data compiled from dried sediments from three water reservoirs at the ancient Maya city of Ucanal, Petén, Guatemala, reveal low to undetectable fecal biomarker concentrations. These low concentrations may be the result of the aerobic decay of sterols combined with well‐managed waste disposal practices.
Jean D. Tremblay, Peter M. J. Douglas, Christina T. Halperin, Yves Gélinas   +3 more
wiley   +1 more source

The Genetic Landscape of Hereditary Spastic Paraplegia in Greece

Clinical Genetics, EarlyView.
We investigated 112 Greek index‐cases with hereditary spastic paraplegia collected over > 25 years using NGS and MLPA. We identified a causative variant in 68 patients (60.7%), including 7 novel causative variants. This study presents a comprehensive overview of the phenotypic and genotypic spectrum of HSP in the Greek population.
Georgios Koutsis, Viorica Chelban, Chrisoula Kartanou, Zoi Kontogeorgiou, Chrysoula Koniari, Nikolaos Ragazos, Charalampos Voudommatis, Kristina Zhelcheska, David S. Lynch, Reza Maroofian, Ehsan Barkhordari, Rahema Mohammad, Ioannis Zaganas, Minas Drakos, Georgia Xiromerisiou, Efthymios Dardiotis, Leonidas Stefanis, Marios Panas, Henry Houlden, Georgia Karadima   +19 more
wiley   +1 more source

High cholesterol absorption efficiency interferes with bile acid metabolism and cholesterol elimination from the body

Journal of Internal Medicine, EarlyView.
Abstract Background Elevated low‐density lipoprotein (LDL) cholesterol causes atherosclerotic cardiovascular diseases. Variables of whole‐body cholesterol metabolism, for example, high cholesterol absorption efficiency, might also be atherogenic, whereas the role of bile acids is controversial.
Piia Simonen, Ingmar Wester, Jyri Lommi, Juha Sinisalo, Helena Gylling   +4 more
wiley   +1 more source

Safety and Effectiveness of Pharmacy Compounded Chenodeoxycholic Acid Capsules for Patients With Cerebrotendinous Xanthomatosis

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT Chenodeoxycholic acid (CDCA) is an essential drug for patients with rare metabolic disease cerebrotendinous xanthomatosis (CTX). To ensure continuation of treatment, the Amsterdam UMC hospital pharmacy developed pharmacy compounded CDCA capsules when the authorized CDCA capsules were no longer available for Dutch patients.
Natalja Bouwhuis, Soumia Majait, Yasmin Polak, Aylene de Jong, Bart A. W. Jacobs, Frédéric M. Vaz, Willemijn G. Leen, E. Marleen Kemper, Eleonora L. Swart, Carla E. M. Hollak   +9 more
wiley   +1 more source

Cholesteryl Fatty Acid Esters and Free Cholesterol in Food of Animal Origin

European Journal of Lipid Science and Technology, Volume 128, Issue 1, January 2026.
Cholesterol occurs in free (bioavailable) and esterified (transport/storage) forms. Here, we present a method that allows both forms to be determined independently. Finally, the quantities of free and esterified cholesterol were determined in several meat, animal fat, and cheese samples.
Vanessa Hermann‐Ene, Janina Stojkaj, Sophie Philippos, Walter Vetter   +3 more
wiley   +1 more source

Arabidopsis root lipid droplets are hubs for membrane homeostasis under heat stress, and triterpenoid synthesis and storage

New Phytologist, Volume 249, Issue 2, Page 892-916, January 2026.
Summary Plant lipid droplets (LDs) and their associated proteins have numerous subcellular and physiological functions. While considerable progress has been made for LDs in many tissues, the function and composition of LDs in roots remain largely unexplored.
Patricia Scholz, Janis Dabisch, Ana C. Vilchez, Alyssa C. Clews, Philipp W. Niemeyer, Magdiel S. S. Lim, Siqi Sun, Lea Hembach, Mayuko Naganawa, Fabienne Dreier, Katharina F. Blersch, Lea M. Preuß, Martin Bonin, Elena Lesch, Yuya Iwai, Takashi L. Shimada, Jürgen Eirich, Iris Finkemeier, Katharina Gutbrod, Peter Dörmann, You Wang, Robert T. Mullen, Till Ischebeck   +22 more
wiley   +1 more source

The Influence of Schwann Cell Metabolism and Dysfunction on Axon Maintenance

Glia, Volume 73, Issue 12, Page 2338-2352, December 2025.
Main Points Sensory neurons depend on Schwann cells for survival. Schwann cells provide energy for axons dunng rapid firing or after injury. Dysregulated metabolism in Schwann cells can lead to the production of neurotoxic and axon degeneration. ABSTRACT Schwann cells are the glial cells in the peripheral nervous system responsible for the production ...
Rose Follis, Vishwanath V. Prabhu, Bruce D. Carter   +2 more
wiley   +1 more source

FDA Approves First Targeted Treatment for Cerebrotendinous Xanthomatosis: A Perspective on a Landmark in Rare Lipid Storage Disease Therapy

Health Science Reports, Volume 8, Issue 12, December 2025.
ABSTRACT Background and Aims Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive disorder caused by mutations in the CYP27A1 gene, leading to deficient sterol 27‐hydroxylase activity. This enzyme is critical for bile acid synthesis, and its dysfunction results in reduced chenodeoxycholic acid (CDCA) levels and subsequent accumulation of ...
Laiba Jalal, Areeba Aamir Ali Basaria, Hermann Yokolo   +2 more
wiley   +1 more source

Information Theory Analysis of CTX Shows Consistent Clinical Presentation

Journal of Inherited Metabolic Disease, Volume 48, Issue 6, November 2025.
ABSTRACT Cerebrotendinous xanthomatosis (CTX) is a rare, metabolic disorder caused by pathogenic variants in CYP27A1. The classic clinical presentation includes infantile‐onset chronic diarrhea, juvenile‐onset bilateral cataracts, with development of tendon xanthomas and progressive neurological dysfunction.
Jennifer Hanson, Penelope E. Bonnen
wiley   +1 more source