Results 191 to 200 of about 381,129 (289)

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

iMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu, Yu An, Yage Du, Zhaoming Cao, Jie Zheng, Jingya Wang, Tingyi Li, Xingen Lei, Yanhui Lu   +8 more
wiley   +1 more source

Temporal response patterns of human gut microbiota to dietary fiber

iMeta, EarlyView.
In this study, 19 overweight participants, with or without type 2 diabetes mellitus, underwent 14 days of normal‐diet observation followed by 14 days of dietary fiber intervention. Fecal samples and continuous glucose monitoring data were collected daily throughout the 28‐day period.
Xiaotong Lin, Chaoxun Wang, Biao Liu, Yin Zhu, Rui Zhai, Chenhong Zhang   +5 more
wiley   +1 more source

Safety Evaluation of Serendipity Berry Sweet Protein From Komagataella phaffii

Journal of Applied Toxicology, EarlyView.
ABSTRACT Serendipity Berry Sweet Protein (sweelin) is a novel hyper‐sweet thermophilic protein designed using Artificial Intelligence Computational Protein Design (AI‐CPD) to improve the stability and sensory profile of the protein found in serendipity berry (Dioscoreophyllum cumminsii).
Yael Lifshitz, Shira Paz, Rotem Saban, Inbar Zuker, Hagay Shmuely, Katy Gorshkov, Jwar Meetro, Shahrzad Tafazoli, Trung Vo, Gabriela Amiram, Carmit Shani Levi, Uri Lesmes, Ilan Samish   +12 more
wiley   +1 more source

Glucocorticoid treatment in early rheumatoid arthritis is independently associated with increased PCSK9 levels: data from a randomised controlled trial. [PDF]

RMD Open
Lend K, Twisk JW, Kumar N, Dijkshoorn B, Lampa J, Rudin A, Hetland ML, Uhlig T, Nordström D, Østergaard M, Gudbjornsson B, Sokka-Isler T, Grondal G, Hørslev-Petersen K, Nurmohamed MT, Frostegård J, van Vollenhoven RF.   +16 more
europepmc   +1 more source

Allergenicity, Genotoxicity and Subchronic Toxicity Assessment of IgG Binding Protein LT Produced From Aspergillus oryzae

Journal of Applied Toxicology, EarlyView.
ABSTRACT Gastrointestinal health is one of the fastest growing areas in the food and beverage industry, as its importance to overall health and well‐being is becoming increasingly recognized. Immunoglobulins play a key role in protecting the gastrointestinal tract, and nonbovine sources of immunoglobulins (including camel milk, which has a long history
Kirt R. Phipps, Sachin Patel, Kevin Scaife, Toby Holmes, Alica Šoltésová, Sandra Wingaard Thrane, Louise Kristine Vigsnæs, Nigel Baldwin, Christel Jørgensen   +8 more
wiley   +1 more source

Introducing Two Novel Indices for Evaluating Coronary Artery Stenosis: Athero‐Inflammatory Index and Athero‐Inflammatory Glucose Index

Journal of Clinical Laboratory Analysis, EarlyView.
In this study, we introduced and investigated two novel indices named athero‐inflammatory (AI) index and athero‐inflammatory glucose (AIG) index with coronary stenosis among a total of 2326 participants (761 angiography (+), 406 angiography (−) and 1159 controls) in Mashhad. We found that AI index and AIG index were better and more reliable markers for
Rana Kolahi Ahari, Mohsen Moohebati, Mohammad Tajfard, Habibollah Esmaily, Gordon Ferns, Majid Ghayour‐Mobarhan, Sara Saffar Soflaei   +6 more
wiley   +1 more source

Emerging risks of lipid-lowering therapy and low LDL levels: implications for eye, brain, and new-onset diabetes. [PDF]

Lipids Health Dis
Cure E, Cumhur Cure M.
europepmc   +1 more source

Lipid management: maximising reduction of cardiac risk [PDF]

, 2013
Gonna, H, Ray, KK, Webb, J
core   +1 more source

Mitochondrial tRNAGlu 14687A>G May Be A Novel Mutation for Type 2 Diabetes Mellitus

Journal of Clinical Laboratory Analysis, EarlyView.
We identified a novel mitochondrial tRNAGlu 14687A>G mutation in a Han Chinese pedigree with diabetes; the m.14687A>G mutation occurred at a conserved nucleotide of tRNAGlu, which was important for tRNA structure and function. Using a cybrid cell model, we found that mutant cells exhibited much more severe mitochondrial dysfunctions than control cells,
Xiaojuan Rao, Liran Xie, Shuangwei Shi, Yifan Fang   +3 more
wiley   +1 more source

Lipid profile and safety of rosuvastatin monotherapy versus rosuvastatin plus ezetimibe in high risk coronary artery disease: a systematic review and meta-analysis of randomized controlled trials. [PDF]

Egypt Heart J
Setyo Adji A, Billah A, Nugraha A, Putra Sit JE, Gervais de Liyis B, Maulana Satrio Aji A, Nur Rosyid R, Edi Suwito B.   +7 more
europepmc   +1 more source