Results 11 to 20 of about 1,814,361 (342)
Signal Transduction and Targeted Therapy, 2022 Disturbed cholesterol homeostasis plays critical roles in the development of multiple diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and cancers, particularly the CVD in which the accumulation of lipids (mainly the ...
Yajun Duan +5 more
semanticscholar +1 more source
Liposomes: Structure, Biomedical Applications, and Stability Parameters With Emphasis on Cholesterol
Frontiers in Bioengineering and Biotechnology, 2021 Liposomes are essentially a subtype of nanoparticles comprising a hydrophobic tail and a hydrophilic head constituting a phospholipid membrane. The spherical or multilayered spherical structures of liposomes are highly rich in lipid contents with ...
Pooria Nakhaei +8 more
semanticscholar +1 more source
Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol.
New England Journal of Medicine, 2020 BACKGROUND Inclisiran inhibits hepatic synthesis of proprotein convertase subtilisin-kexin type 9. Previous studies suggest that inclisiran might provide sustained reductions in low-density lipoprotein (LDL) cholesterol levels with infrequent dosing ...
K. Ray +10 more
semanticscholar +1 more source
Serum cholesterol response to dietary cholesterol [PDF]
The American Journal of Clinical Nutrition, 1984 Serum cholesterol change, delta Chol mg/dl, from change only in dietary cholesterol, mg/1,000 kcal, x, was analyzed with data from 39 controlled experiments on 64 adults with the model delta Chol = b(x2k-x1k). Values of b were found by iteration for exponents k = 0.3 to k = i.0 yielding eight regression equations to check predicted against observed ...
openaire +3 more sources
From Dietary Cholesterol to Blood Cholesterol
Nutrients, 2023 The Nutrients’ Special Issue “From dietary cholesterol to blood cholesterol” aims to supply existing knowledge and novel new research data about human cholesterol (C) fluxes [...]
openaire +2 more sources
Gut, 2020 Objective Non-alcoholic fatty liver disease (NAFLD)-associated hepatocellular carcinoma (HCC) is an increasing healthcare burden worldwide. We examined the role of dietary cholesterol in driving NAFLD–HCC through modulating gut microbiota and its ...
Xiang Zhang +10 more
semanticscholar +1 more source
Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis. [PDF]
, 2016 Liver X receptors (LXRs) are transcriptional regulators of cellular and systemic cholesterol homeostasis. Under conditions of excess cholesterol, LXR activation induces the expression of several genes involved in cholesterol efflux, facilitates ...
Casero, David +13 more
core +2 more sources
, 1968 Acute cholesterol depletion is generally associated with decreased or abolished T cell signalling but it can also cause T cell activation. This anomaly has been addressed in Jurkat T cells using progressive cholesterol depletion with methyl-beta ...
Adler, Jeremy +3 more
core +2 more sources
Studies on the clinical significance of nonesterified and total cholesterol in urine [PDF]
, 1981 Gas-liquid chromatographic determinations of nonesterified and total urinary cholesterol were performed in 137 normals, 264 patients with various internal diseases without evidence of neoplasias or diseases of the kidney or urinary tract, 497 patients ...
A. Pickel +35 more
core +2 more sources
Changes to cholesterol trafficking in macrophages by Leishmania parasites infection [PDF]
, 2017 Leishmania spp. are protozoan parasites that are transmitted by sandfly vectors during blood sucking to vertebrate hosts and cause a spectrum of diseases called leishmaniases.
Anderson +67 more
core +2 more sources