Results 11 to 20 of about 1,802,229 (363)

Breaking the Cycle, Cholesterol Cycling, and Synapse Damage in Response to Amyloid-ß [PDF]

, 2017
Soluble amyloid-β (Aβ) oligomers, a key driver of pathogenesis in Alzheimer disease, bind to cellular prion proteins (PrPC) expressed on synaptosomes resulting in increased cholesterol concentrations, movement of cytoplasmic phospholipase A2 (cPLA2) to ...
Bate, C
core   +2 more sources

A Body shape index significantly predicts MRI-defined abdominal adipose tissue depots in non-obese Asian Indians with type 2 diabetes mellitus

BMJ Open Diabetes Research & Care, 2020
Introduction We aimed to determine the correlations of volumes of subcutaneous abdominal adipose tissue (SCAT) (anterior, posterior, superficial and deep), total SCAT, intraperitoneal adipose tissue, retroperitoneal abdominal adipose tissue (RPAT), total
Shajith Anoop, Jesse Krakauer, Nir Krakauer   +2 more
doaj   +1 more source

The cholesterol ester cycle regulates signalling complexes and synapse damage caused by amyloid-ß [PDF]

, 2017
Cholesterol is required for the formation and function of some signalling platforms. In synaptosomes, amyloid-β (Aβ) oligomers, the causative agent in Alzheimer's disease, bind to cellular prion proteins (PrPC) resulting in increased cholesterol ...
Anderson, Bate, Bate, Bate, Baxter, Bryleva, Chan, Chang, Chen, Chen, Chiarini, Chiesa, Dunkley, Gaudreault, Gilch, Giuffrida, Gocze, Gylys, Hammond, Herms, Hosie, Kaneko, Kawarabayashi, Koch, Laurén, Linden, Linetti, Lingwood, Lingwood, London, Maglio, Maxfield, Mc Donald, McLean, Montine, Moskowitz, Mouillet-Richard, Nalefski, Naslavsky, Osborne, Pani, Puglielli, Rajendran, Robinet, Ryan, Schroeder, Selkoe, Shankar, Sharma, Simons, Solforosi, Stahl, Sugiyama, Suzuki, Taraboulos, Walsh, Williamson, Yang   +57 more
core   +1 more source

Enzymatic determination of total serum cholesterol.

Clinical Chemistry, 1974
An enzymatic method is described for determination of total serum cholesterol by use of a single aqueous reagent. The method requires no prior treatment of sample and the calibration curve is linear to 600 mg/dl. Cholesterol esters are hydrolyzed to free
C. C. Allain, L. Poon, C. Chan, W. Richmond, P. Fu   +4 more
semanticscholar   +1 more source

Randomized Control Trial for Reduction of Body Weight, Body Fat Patterning, and Cardiometabolic Risk Factors in Overweight Worksite Employees in Delhi, India

Journal of Diabetes Research, 2017
Background. We studied the impact of the multicomponent interventions on body weight and cardiometabolic risk factors in overweight individuals working in corporate worksites. Methods.
Usha Shrivastava, Mahrukh Fatma, Smriti Mohan, Padam Singh, Anoop Misra   +4 more
doaj   +1 more source

Gypenosides Prevent and Dissolve Cholesterol Gallstones by Modulating the Homeostasis of Cholesterol and Bile Acids

Frontiers in Medicine, 2022
Gypenosides (GPs), obtained from Gynostemma pentaphyllum (Thunb.) Makino, have been traditionally prescribed to treat metabolic disorders in Asians. This study assessed whether GPs could prevent lithogenic diet (LD)-induced cholesterol gallstone (CG ...
Qian Zhuang, Jinnian Cheng, Jie Xia, Min Ning, Shan Wu, Shuang Shen, Yan Shi, Dan Huang, Zhixia Dong, Xinjian Wan   +9 more
doaj   +1 more source

Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol.

New England Journal of Medicine, 2020
BACKGROUND Inclisiran inhibits hepatic synthesis of proprotein convertase subtilisin-kexin type 9. Previous studies suggest that inclisiran might provide sustained reductions in low-density lipoprotein (LDL) cholesterol levels with infrequent dosing ...
K. Ray, R. Wright, D. Kallend, W. Koenig, Lawrence A Leiter, F. Raal, Jenna A Bisch, T. Richardson, M. Jaros, P. Wijngaard, J. Kastelein   +10 more
semanticscholar   +1 more source

The differentiation of cholesterol and pigment gallstones [PDF]

, 1989
Gallbladder biles and stones were obtained at 116 cholecystectomies for symptomatic gallstone disease. All 33 patients younger than 50 years had cholesterol stones, whereas 40% of the older patients had pigment stones.
Carey, Holan, Pomeranz, Sackmann, Thistle, Trotman   +5 more
core   +1 more source

The Structure of Cholesterol in Lipid Rafts [PDF]

Physical Review Letters 113, 228101 (2014), 2014
Rafts, or functional domains, are transient nano- or mesoscopic structures in the plasma membrane and are thought to be essential for many cellular processes such as signal transduction, adhesion, trafficking and lipid/protein sorting. Observations of these membrane heterogeneities have proven challenging, as they are thought to be both small and short-
arxiv   +1 more source

Cholesterol nucleation time in gallbladder bile of patients with solitary or multiple cholesterol gallstones [PDF]

, 1992
Patients with multiple cholesterol gallbladder stones have been found to be at a higher risk for the recurrence of gallstones after successful nonsurgical treatment than those with a solitary stone.
Abell, Admirand, Carey, Carey, Christoph von Ritter, Dieter Jüngst, Ekkehard Pratschke, Fiske, Gollish, Groen, Gustav Paumgartner, Holan, Lanzini, O'Donnel, Pattinson, Pomeranz, Sackmann, Schriever, Sedaghat, Shiffman, Smallwood, Spengler, Talalay, Tera, Thomas Lang, Van Erpecum, Villanova, Whiting   +27 more
core   +1 more source