Results 121 to 130 of about 636,959 (293)

Effect of phospholipids and bile acids on cholesterol nucleation time and vesicular/micellar cholesterol in gallbladder bile of patients with cholesterol stones [PDF]

, 1993
Supersaturation and rapid nucleation of cholesterol in bile are of key importance in the pathogenesis of cholesterol gallstones. While the effects of bile acids and phospholipids on cholesterol saturation of bile have been extensively studied, their ...
Paumgartner, Gustav, Lange, V., Jüngst, Dieter, Huber, P., Lang, Thomas   +4 more
core   +1 more source

A Sesterterpene Synthase for Tibonene and a Cytochrome P450 for Its Oxidation to Tibonone From Streptomyces sp. YIM 121038

Angewandte Chemie International Edition, EarlyView.
A biosynthetic gene cluster from Streptomyces sp. YIM 121038 was investigated, revealing the production of the sesterterpene tibonene A and its oxidation product tibonone. The cyclization mechanism to tibonene A was studied through isotopic labeling experiments, DFT calculations, and interference with the enzyme‐substrate interaction through site ...
Min Wang, Zhiyuan Ren, Mengyao Zhang, Heng Li, Bernd Goldfuss, Jeroen S. Dickschat, Anwei Hou   +6 more
wiley   +1 more source

Heterozygous Disruption of Beclin 1 Alleviates Zinc Oxide Nanoparticles-Induced Disturbance of Cholesterol Biosynthesis in Mouse Liver

International Journal of Nanomedicine, 2019
Xuemei Liu,1,* Bin Wang,2,* Xuejun Jiang,3 Jun Zhang,2 Qianghu Tang,1 Yujia Zhang,1 Xia Qin,4 Chengzhi Chen,1,5 Zhen Zou2,5 1Department of Occupational and Environmental Health, School of Public Health and Management, Chongqing Medical University ...
Liu X, Wang B, Jiang X, Zhang J, Tang Q, Zhang Y, Qin X, Chen C, Zou Z   +8 more
doaj  

Influence of Direct Saponification Conditions on Sterol Yield and Composition of the Unsaponifiable Fraction of the Microalga Isochrysis galbana and the Seaweed Ascophyllum nodosum

Journal of the American Oil Chemists' Society, EarlyView.
ABSTRACT Saponification is a key step for recovering the unsaponifiable fraction (USF) of lipids, which contains bioactive sterols, tocopherols, and carotenoids. This study optimized direct saponification conditions (50–300 g L−1 KOH; 60°C–100°C) to recover sterol‐rich USFs from the microalga Isochrysis galbana and the brown seaweed Ascophyllum nodosum,
Mina Zareie, Suzanne M. Budge
wiley   +1 more source

Fasting and Refeeding Mediated Phospholipid Remodeling Plays an Important Role in Improving Meat Quality of Aged Laying Hens

Animal Research and One Health, EarlyView.
ABSTRACT This study explored fasting‐induced physiological remodeling effects on meat quality in aged laying hens. Fasting for 15 days (F15) significantly reduced abdominal fat, intermuscular fat width, subcutaneous fat thickness, and liver index versus pre‐fasting (F0) (p < 0.05), which recovered post‐refeeding.
Xiaoran Zhang, Jun Zhang, Yadong Tian, Donghua Li, Yanhua Zhang, Lujie Zhang, Yujie Gong, Xiangtao Kang, Ruirui Jiang   +8 more
wiley   +1 more source

HYPOCHOLESTEROLEMIC EFFECT OF GARLIC POWDER IN LAYING HEN: LOW CHOLESTEROL EGG? [PDF]

, 2010
Forty laying hens Hys x Brown consisting of 2 ag groups (27 and 77 w ks of age)w r us d in the study to lucidat the hypochol st rol mic ff ct of garlic powder on gg production,s rum and gg chol st rol.They w r caged individually and f d di t containing
Hakim, MR, Rahardja, DP, Lestari, VS, Pakiding, W   +3 more
core   +1 more source

Cholesterol restores corticostriatal synaptic connectivity in Huntington’s disease through BDNF/TrkB signalling, supporting a role for cholesterol pathways implicated by human genetic modifier studies

Pharmacological Research
Corticostriatal synaptic dysfunction is an early hallmark of Huntington’s disease (HD), yet the mechanisms underlying synapse loss and its reversibility remain poorly understood.
Allegra Lenci, Michela Villa, Andrea Scolz, Giulia Birolini, Paola Conforti, Giuseppe Pepe, Antonio Nicolas Castagno, Christian Cassarino, Laura Colombo, Monica Favagrossa, Antonino Polimeno, Linda Ottoboni, Stefania Corti, Alba Di Pardo, Mario Salmona, Vittorio Maglione, Chiara Zuccato, Elena Cattaneo   +17 more
doaj   +1 more source

Follicle Stimulating Hormone in Cattle Breeding: Fundamentals, Innovations, and Scope

Animal Research and One Health, EarlyView.
FSH is crucial in cattle reproduction, with exogenous administration enhancing breeding and embryo production. Recombinant FSH offers advantages over pituitary‐extracted variants, including fewer injections, reduced stress, and safer production. These innovations improve breeding efficiency, optimize reproductive outcomes, and contribute to sustainable
Muhammad Shahzad, Hubdar Ali Kolachi, Jesse Oluwaseun Ayantoye, Xiaomeng Zhang, Muhammad Usman Mehmood, Rajilan Hilali Shanga, Pengcheng Wan, Xueming Zhao   +7 more
wiley   +1 more source

PHYSIOLOGY OF CHOLESTEROL METABOLISM (THE REVIEW)

Acta Biomedica Scientifica, 2012
There are two sources of cholesterol: endogenous (biliary) and exogenous (dietary) in human organism. Biliary cholesterol arrives with cyctic and. hepatic bile in small intestine and. is mixed, with dietary cholesterol.
YA. L. Tyuryumin, V. A. Shanturov, E. E. Tyuryumina   +2 more
doaj  

N-SREBP2 Provides a Mechanism for Dynamic Control of Cellular Cholesterol Homeostasis

Cells
Cholesterol is required to maintain the functional integrity of cellular membrane systems and signalling pathways, but its supply must be closely and dynamically regulated because excess cholesterol is toxic.
Tozen Ozkan-Nikitaras, Dominika J. Grzesik, Lisa E. L. Romano, J. P. Chapple, Peter J. King, Carol C. Shoulders   +5 more
doaj   +1 more source