Results 111 to 120 of about 636,959 (293)
Advanced Science, EarlyView.Lipid stress drives O‐GlcNAcylation of the m6A demethylase FTO at Ser195, enhancing its stability and demethylase activity. This modification removes m6A from HRAS mRNA, preventing its degradation and activating PI3K/AKT signaling to promote hepatic steatosis and inflammation.
Jia‐Xin Yin +9 more
wiley +1 more source
, 1960 Fatty acid, cholesterol, and acetoacetate biosynthesis was studied with liver homogenates from normal and starved guinea pigs. Starvation suppressed the incorporation of acetate into fatty acids and cholesterol but not into acetoacetate.
Frank Sauer
core +1 more source
Advanced Science, EarlyView.HADHA K406 lactylation fuels fatty acid β‐oxidation and HMGCR‐dependent cholesterol biosynthesis, fostering immunosuppressive MDSCs and exhausted CD8+ T cells in gastric cancer. Loss of this modification blocks cholesterol production, remodels the tumor microenvironment, and tumor growth is suppressed via combined inhibition of HMGCR and LDHA ...
Maoxiao Feng +10 more
wiley +1 more source
Advanced Science, EarlyView.During kainic acid‐induced epileptogenesis, astrocyte‐associated ATP‐binding cassette transporter A1 (ABCA1) and apolipoprotein E (APOE) responses accompany ectopic neurons and exploratory lipid alterations. In separate cohorts, bexarotene pretreatment and treatment on days 14–21 are associated with fewer ectopic hilar neurons and lower chronic seizure
Lu Chen +10 more
wiley +1 more source
A Review of Cholesterol Biosynthesis Pathway
International Journal of Clinical and Medical ResearchCholesterol biosynthesis is an essential, tightly controlled biochemical process in human physiology. It is an essential part of membrane fluidity, cellular homeostasis, and for synthesis of steroid hormone and bile acid. The review will address the fine
A. Kadhim, Shatha R. Zaidan
doaj +1 more source
Functional analysis of cholesterol biosynthesis by RNA interference.
, 2007 Inborn errors of cholesterol biosynthesis caused by dysfunctionality of single enzymes are known to cause severe malformation syndromes like X-linked chondrodysplasia punctata (CDPX2), CHILD syndrome or Smith-Lemli-Opitz-syndrome (SLOS). In this study we
Adamski, J., Ilgen, D., Guggenberger, C.
core +1 more source
Advanced Science, EarlyView.MG‐1 is a bifunctional small molecule that enhances the removal of damaged mitochondria through autophagy, the cell's recycling pathway. Its activity increases under mitochondrial stress, with minimal effects on basal autophagy. MG‐1 also improves movement in a zebrafish model of mitochondrial dysfunction, supporting further investigation of this ...
Ratislav M. Ozhiganov +24 more
wiley +1 more source
Advanced Science, EarlyView.A first single‐cell atlas of human orchitis reveals coordinated germ‐cell loss, somatic niche dysfunction, and immune‐metabolic remodeling. Aberrant SREBP2 activation in testicular somatic cells emerges as a central pathogenic node, while Fatostatin‐mediated inhibition of the SREBP pathway improves spermatogenesis, fibrosis, and lipid accumulation in a
Yanlin Tang +16 more
wiley +1 more source
Fate of the 16β-hydrogen atom of cholesterol in the biosynthesis of tomatidine and solanidine
, 1977 During the biosynthesis of tomatidine (1) in Lycopersicon pimpinellifolium, the 16β-hydrogen atom of cholesterol is inverted to the 16α-position; the same hydrogen atom is lost during the biosynthesis of solanidine (2) in Solanum ...
L. Canonica +3 more
core +1 more source