Results 91 to 100 of about 636,959 (293)

Biosynthesis of Cholesterol in Animal Blood.

Experimental Biology and Medicine, 1958
SummaryA study of biosynthesis of cholesterol in vitro from radioactive acetate in animal blood was undertaken. Degree of incorporation of acetate into cholesterol was higher in calf blood than in pig blood samples. Cholesterol synthesized in rat, rabbit, cow, and piglet blood samples had comparatively a very low radioactivity.
V S, RAUT, C A, FISH, G, PINCUS
openaire   +2 more sources

Oral Recombinant Human Collagen III Protects Gastric Mucosa via G‐Quadruplex‐Mediated Activation of the Pla2g4a‐Prostaglandin Axis

Advanced Science, EarlyView.
Orally administered recombinant human type III collagen protects the gastric mucosa from ethanol‐induced injury by coordinating redox homeostasis, epithelial barrier repair, and arachidonic acid–prostaglandin metabolism. Gastric digestion releases the pentapeptide GPAEF, which interacts with the Pla2g4a promoter G‐quadruplex in a structure‐dependent ...
Xinyue Lan, Qiu Dai, Yanhui Wang, Jiaxuan Gu, Chengyun Wang, Weicheng Xu, Xinru Gao, Jiageng Cheng, Wentao Geng, Xiaowen Wu, Haihang Li, Xiaoyun He, Shengwei Fu, Longjiao Zhu, Wentao Xu   +14 more
wiley   +1 more source

Studies on the link between HMG-CoA reductase and cholesterol 7 alpha-hydroxylase in rat liver.

Journal of Lipid Research, 1988
Under most experimental conditions, there is a covariation between the rate-limiting enzyme in cholesterol biosynthesis, HMG-CoA reductase, and the rate-limiting enzyme in bile acid biosynthesis, cholesterol 7 alpha-hydroxylase.
I Björkhem, J E Akerlund
doaj   +1 more source

Vitamin B12 deficiency induces cholesterol biosynthesis by limiting S-adenosyl methionine and altering the methylation of Srebf1 and Ldlr genes

Maternal vitamin B12 deficiency affecting one-carbonmetabolism influences metabolic status and the degree of insulinresistance of the offspring in adulthood.
Adaikalakoteswari, A, Voyias, P.D, Al-Daghri, N.M, Smart-Halajko, M, Bawazeer, N, Moore, J, McCarthy, C, McTernan, P.G, Finer, S   +8 more
core   +1 more source

Pathways of hepatic cholesterol and Coenzyme Q₁₀ (CoQ10) biosynthesis in liver.

, 2014
Pathways of hepatic cholesterol and Coenzyme Q10 (CoQ10) biosynthesis in liver.
Qixuan Chen (629874), Mahemuti Laziyan (629877), Nimal Ratnayake (629884), Maria Florian (629873), Ryan J. Mailloux (50825), Melanie C. Coughlan (629876), Jocelyn Truong (629882), Don Caldwell (455020), Ivan Petrov (629875), Nanqin Li (629885), Claude Gagnon (629880), William G. Willmore (190943), Jin Yan (193119), Hing Man Chan (629883), Kurtis Sarafin (629881), Michelle Lalande (629878), Dominique Patry (629879), Xiaolei Jin (428624)   +17 more
core   +1 more source

Extracellular Vesicle Packaged TDP43 Derived From ECs Exacerbates Cigarette Tar‐Related Atherosclerosis Progression via Enhancing Macrophage Extracellular Traps

Advanced Science, EarlyView.
Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Xinxin Zhu, Yuwu Chen, Wei Meng, Biyi Xu, Junke Mou, Xiaolin Liu, Mengyang Wang, Qishuo Gu, Qianhui Sun, Man Li, Chen Zhao, Ming Zeng, Ying Lv, Boling Yi, Sheng Qu, Xiaoxuan Bai, Ji Li, Xing Luo, Sining Hu, Bo Yu, Haibo Jia   +20 more
wiley   +1 more source

The differentiation of cholesterol and pigment gallstones [PDF]

, 1989
Gallbladder biles and stones were obtained at 116 cholecystectomies for symptomatic gallstone disease. All 33 patients younger than 50 years had cholesterol stones, whereas 40% of the older patients had pigment stones.
Jüngst, Dieter
core   +1 more source

USP4‐Dependent CHAF1B Stabilization Regulates Distinct SETDB1 Ubiquitin States Linked to AKT T308 Signaling and Lipogenic Remodeling in HCC

Advanced Science, EarlyView.
USP4 stabilizes CHAF1B by limiting K48‐linked ubiquitination. Stabilized CHAF1B supports UHRF1‐associated K63‐linked SETDB1 ubiquitination and cytoplasmic redistribution, whereas CHAF1B loss favors VHL‐dependent K11‐associated degradative ubiquitination and proteasomal loss of SETDB1.
Saiyan Bian, Yun Tong, Wenkai Ni, Zhangzhi Tang, Weiting Chen, Kexin Ma, Lihan Jiang, Jiayu Shao, Xuyang He, Wenjie Zheng   +9 more
wiley   +1 more source

Mechanism for FGF-1 to regulate biogenesis of apoE-HDL in astrocytes

Journal of Lipid Research, 2007
Fibroblast growth factor-1 (FGF-1) is secreted by astrocytes and stimulates apolipoprotein E (apoE)-HDL biogenesis by an autocrine mechanism to help in recovery from brain injury.
Jin-ichi Ito, Yuko Nagayasu, Kuniko Okumura-Noji, Rui Lu, Tomo Nishida, Yutaka Miura, Kiyofumi Asai, Alireza Kheirollah, Seiichi Nakaya, Shinji Yokoyama   +9 more
doaj   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source