Results 161 to 170 of about 636,959 (293)

Modeling Inherited Disorders of Post-Lanosterol Cholesterol Biosynthesis: From Animal Models to Patient-Derived Stem Cells. [PDF]

Int J Mol Sci
Akhmetzyanova E, Nasybullina E, Rizvanov A, Mukhamedshina Y.   +3 more
europepmc   +1 more source

Conserved SERPINE2 function maintains ovarian estrogen production to support fertility in goats and mice

iMetaOmics, EarlyView.
Single‐nucleus RNA sequencing and functional profiling of goat ovaries with divergent litter sizes revealed prolificacy‐associated granulosa cell (GC) states characterized by enhanced proliferation‐ and steroidogenesis‐related features, together with altered predicted cell–cell communication.
Sanbao Zhang, Yirong Wei, Xiaoping Guo, Ruimen Zhang, Yingming Wei, Yanna Huang, Qinyang Jiang   +6 more
wiley   +1 more source

SREBP2 promotes macrophage alternative activation and allergic airway inflammation independent of cholesterol biosynthesis. [PDF]

Cell Death Dis
Wu Y, Zheng K, Dong L, Gao S, Wu Y, Liu Z, Li J, Chen H, Weng Q, Li M, Zhu C, Xu J, Ying S, Chen Z, Li W.   +14 more
europepmc   +1 more source

Inhibition of cholesterol biosynthesis under hypoxia

, 2006
Oxygen balance is very important and tightly regulated in mammals. Under hypoxia, hypoxia inducible factor 1(HIF-1) dimerizes with hypoxia inducible factor 1? (HIF-) and activates expression of several genes.
Tan, Qiulin
core  

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

Hepatocyte‐Centered Regulation of MASH Fibrosis: From Animal Models to Molecular Mechanisms and Targeted Therapies

iNew Medicine, EarlyView.
This review highlights hepatocytes as active regulators of MASH fibrosis through secreted proteins, metabolites, and extracellular vesicles that modulate hepatic stellate cell activation. These hepatocyte–stellate cell communication pathways provide a mechanistic framework for developing targeted antifibrotic therapies, including hepatocyte‐directed ...
Eui Jung Jung, Xiaobo Wang
wiley   +1 more source

APOC1⁺IFI30⁺ TAMs orchestrate colorectal cancer liver metastasis by coupling cholesterol biosynthesis with secretion of immunosuppressive factors. [PDF]

Cell Mol Life Sci
Cai Z, Chen Y, Cui L, Yao J, Qiao J, Sun W, Liu H, Yang L, Yang Z, Liu Q, Hou B, Zou Z, Lai D.   +12 more
europepmc   +1 more source

Biochemical and Molecular Insights Into Monocrotaline‐Induced Hepatotoxicity: An Experimental Mouse Study

Journal of Applied Toxicology, EarlyView.
ABSTRACT Monocrotaline (MCT), a plant‐derived pyrrolizidine alkaloid, is well known for its hepatotoxic effects. However, full elucidation of the mechanisms underlying MCT‐induced hepatotoxicity, as well as the development of reliable biomarkers for early detection and monitoring, requires an integrated evaluation of biochemical, molecular, and ...
Ali Şenol, Alparslan Kadir Devrim, Miyase Çinar, Mahmut Sözmen, Fatma Betül Akça   +4 more
wiley   +1 more source

An environmentally relevant mixture of organophosphate esters induces cholesterol biosynthesis in THP-1 macrophages. [PDF]

Toxicol Sci
Giles BH, Robaire B, Mann KK.
europepmc   +1 more source

Bisphenol A and Its Analogs: Toxicity Analysis in Mouse and Rat Liver—A Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) and its analogs are widely recognized for their use in industry and plastic manufacturing. Consequently, humans and animals are continually exposed to various substances in their daily lives. This review evaluates the hepatic toxicity of BPA and its analogs in mice and rats, with particular emphasis on molecular mechanisms ...
Sevda Bagdatli, Muhammed Canik, Gizem Gencay, Nurbanu Zengin, Tarık Dinc, Nazan Deniz Yön   +5 more
wiley   +1 more source