Results 211 to 220 of about 636,959 (293)

MiR-181a-driven downregulation of cholesterol biosynthesis through SREBP2 inhibition suppresses uveal melanoma metastasis. [PDF]

J Exp Clin Cancer Res
Wang R, Gilbert C, Tahiri H, Yang C, Landreville S, Hardy P.   +5 more
europepmc   +1 more source

Betulinic Acid Counteracts Statin‐Induced PCSK9 Upregulation Through FXR/SHP‐Associated Signaling

Phytotherapy Research, EarlyView.
Betulinic acid attenuates atorvastatin‐induced increases in PCSK9 expression and secretion while maintaining or increasing LDLR expression in hepatocyte‐derived cells. Mechanistic studies support the involvement of FXR/SHP signaling and show increased SHP–SREBP2 association.
Chan‐Woong Park, Mingoo Bae, Pureum Kang, Na Young Lee, Ja Hyun Koo, Young Hee Choi, Young‐Won Chin   +6 more
wiley   +1 more source

The Cholesterol Biosynthesis Pathway Plays an Important Role in Chemotherapeutic Drug Response and Metastasis in High-Grade Osteosarcoma. [PDF]

Cells
Sukhamwang A, Pruksakorn D, Dejkriengkraikul P, Sangphukieo A, Dissook S, Yodkeeree S.   +5 more
europepmc   +1 more source

Peptide‐based antibacterial nanoplatforms: Design principles, stimuli‐regulated behaviors, and applications

Responsive Materials, EarlyView.
Peptide‐based antibacterial nanoplatforms, encompassing self‐assembled peptides and peptide‐engineered inorganic, polymeric, and lipid nanocarriers, are systematically reviewed. The article highlights design principles and stimuli‐responsive regulation for improving peptide stability, delivery efficiency, and antibacterial performance.
Peng Tan, Chenlong Zhou, Shuaikang Yang, Zhenduo Chen, Guanghui Zhao, Qi Tang, Haoyu Yan, Feng Li, Xi Ma   +8 more
wiley   +1 more source

Cholesterol biosynthesis induced by radiotherapy inhibits cGAS-STING activation and contributes to colorectal cancer treatment resistance. [PDF]

Exp Mol Med
Zhu L, Tang Z, Jiang W, Dong Y, Li X, Huang K, Wu T, Xu L, Guo W, Gu Y.   +9 more
europepmc   +1 more source

Oral Microalgae‐Laden Hydrogels Modulating the Intestinal Microbiota Metabolism for Acute Alcohol‐Induced Liver Injury Therapy

Small, EarlyView.
A food‐grade microalgae‐laden hydrogel (FMH) enables efficient in situ microalgae cultivation and serves as an oral therapeutic platform for acute alcohol‐induced liver injury. FMH improves alcohol tolerance, alleviates oxidative stress, inflammation, and lipid metabolic disorders, restores gut microbial homeostasis, and provides synergistic ...
Zhixin Hu, Hongtao Wu, Xuanqi Liu, Xinxu Huang, Linli Jiang, Lei Liu, Xiaojie Li, Yawen Yao, Fengzheng Gao, Kui Zeng, Jiajing Zhou   +10 more
wiley   +1 more source

PBX3-HMGCR Axis Promotes Hepatocellular Carcinoma Progression Through Enhancing De Novo Cholesterol Biosynthesis. [PDF]

Int J Mol Sci
Zhang X, Qiu L, Zhang L, Li W, Xiang D, Wang J, Wu S, Kasim V.   +7 more
europepmc   +1 more source

Oxaziridines: Versatile Reagents in Modern Organic Synthesis

The Chemical Record, EarlyView.
Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra, Subba Rao Cheekatla, Keshaba Nanda Parida   +2 more
wiley   +1 more source

Author Correction: Enhanced CHOLESTEROL biosynthesis promotes breast cancer metastasis via modulating CCDC25 expression and neutrophil extracellular traps formation. [PDF]

Sci Rep
Tang Q, Liang B, Zhang L, Li X, Li H, Jing W, Jiang Y, Zhou F, Zhang J, Meng Y, Yang X, Yang H, Huang G, Zhao J.   +13 more
europepmc   +1 more source

Microplastics and the Endocrine–Metabolic Interface: Novel Diagnostic Tools Targeting Thyroid–Adipose Axis

Environmental Toxicology, EarlyView.
ABSTRACT Microplastics (MPs) have been identified as major environmental contaminants that can affect organisms directly and act as carriers of particles and chemical additives, thereby aggravating endocrine networks that coordinate metabolic homeostasis.
Sunday Amos Onikanni, Babasola Aiyeku, Marjorie Dardis Murucci, Temitope Aribigbola, Kenia Bispo, Oluwatosin Stella Olayinka, Rômulo Sperduto Dezonne, Sara Gemini Piperni, Paula Soares, Denise Pires de Carvalho, Leandro Miranda‐Alves   +10 more
wiley   +1 more source