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Biosynthesis of Cholesterol and Other Sterols
Chemical Reviews, 2011 Cholesterol and its relatives possessing the 1,2-cyclopentanoperhydrophenanthrene ring system (Figure (Figure1)1) form the sterolome, which comprises a chemical library of more than 1000 natural products found in all forms of eukaryotes and some prokaryotes that serve a myriad of biological functions.1,2 The structural and stereochemical commonality ...
W David Neş
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Cholesterol Biosynthesis: Lanosterol to Cholesterol
Journal of Chemical Education, 2002Cholesterol is an important biochemical, medical, and commercial molecule. In the pathway for cholesterol biosynthesis, biochemistry textbooks discuss the synthesis of lanosterol from acetate in detail. However, the conversion of lanosterol to cholesterol is most often simply indicated as a multistep process, without elaboration.
John Risley
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An Inhibitor of Cholesterol Biosynthesis
Nature, 1964THE belief that hypercholesterolaemia plays a contributory part in the aetiology of atherosclerosis has stimulated the search in many laboratories for compounds which would lower serum cholesterol by inhibition of endogenous cholesterol synthesis.
C, CHAPPEL +7 more
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Regulation of Cholesterol Biosynthesis
Annual Review of Nutrition, 1986THE CHOLESTEROL BIOSYNTHETIC PATHWAy. . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . . . . . . . . 245 Introduction . . . . . . . ........ 245 Overview of Polyisoprenoid Synthesis and the Role of HMG-CoA Reductase ......... 246 Endogenous and Exogenous Factors Regulating HMG-CoA Reductase Activity . . .. . .
H, Rudney, R C, Sexton
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Cholesterol biosynthesis and metabolism
Cardiovascular Drugs and Therapy, 1992Cholesterol plays an essential role in cell membrane synthesis and in cell growth and differentiation. In mammalian cells, cholesterol can be synthesized from acetate precursors or taken up from dietary or exogenous sources. The major catabolic route for disposal of cholesterol involves conversion into excretable bile acids.
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Cholesterol Biosynthesis: A Mechanistic Overview
Biochemistry, 2016Cholesterol is an essential component of cell membranes and the precursor for the synthesis of steroid hormones and bile acids. The synthesis of this molecule occurs partially in a membranous world (especially the last steps), where the enzymes, substrates, and products involved tend to be extremely hydrophobic.
Nuno M F S A, Cerqueira +7 more
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Inherited Disorders of Cholesterol Biosynthesis
Neuropediatrics, 2001Defects of cholesterol biosynthesis comprise a heterogeneous group of disorders, most of which have only been recently described and more are likely to follow in the near future. Mevalonic aciduria (MVA) and hyperimmunoglobulinemia D syndrome (HIDS) are due to allelic defects in mevalonate kinase, an enzyme located proximally in the pathway of ...
D, Haas, R I, Kelley, G F, Hoffmann
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Inherited disorders of cholesterol biosynthesis
Clinical Genetics, 2002For many decades, cholesterol has been considered an important structural component of cellular membranes and myelin, and a precursor of steroid hormones and bile acids. Moreover, the recognition that high cholesterol levels (hypercholesterolemia) are a major risk factor for the development of heart disease and atherosclerosis has gained enormous ...
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Inborn Errors of Cholesterol Biosynthesis
Advances in Pediatrics, 2000Disorders of cholesterol biosynthesis have recently emerged as important errors of metabolism that collectively have taught us many new genetic and biochemical lessons. Whereas most metabolic diseases are characterized by exclusively or largely postnatal biochemical toxicities or deficiencies, disorders of cholesterol biosynthesis are notable for their
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Inhibition of Cholesterol Biosynthesis in Man
Archives of Internal Medicine, 1958The treatment of atherosclerosis has for many years centered around attempts to lower the serum cholesterol level. The rationale for such therapy rests entirely on the statistically significant correlation which exists between coronary atherosclerosis and elevated serum cholesterol levels.
G L, CURRAN, D L, AZARNOFF
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