Results 161 to 170 of about 50,002 (295)

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

British Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source

Cross-talk between lipopolysaccharide tolerance and AGEs in the regulation of macrophage inflammation and cholesterol efflux. [PDF]

Front Immunol
Santos DR, Mello Santana MF, Palanca E, Vancini MG, de Assis SIS, Santos AS, Barbeiro DF, Ariga SKK, Correa-Giannella ML, Soriano FG, Passarelli M.   +10 more
europepmc   +1 more source

Gasdermin‐Mediated Pyroptosis: Novel Strategies Against Colorectal Cancer

Cancer Science, EarlyView.
Pyroptosis is a double‐edged sword in colorectal cancer (CRC): chronic low‐grade pyroptosis promotes tumor progression, whereas acute induction of pyroptosis in cancer cells triggers antitumor immunity and enhances therapeutic response. Targeting gasdermin‐mediated pyroptosis represents a promising strategy for CRC treatment.
Kaibo Guo, Yuqian Feng, Jiamin Lu, Nuerbiye Abudurexiti, Xinlei Zhou, Mengfan Wei, Song Zheng   +6 more
wiley   +1 more source

Cholesterol efflux protein, ABCA1, supports anticancer functions of myeloid immune cells. [PDF]

Sci Adv
Bendre SV, Wang Y, Hajyousif B, K C R, Bhogale SG, Pradeep D, Krawczynska N, Schane CP, Weisser E, Singh A, Han S, Kim H, Kockaya L, Das Gupta A, Nelczyk AT, Vidana Gamage HE, Fei Y, Rodríguez-Casiano D, Guo X, Li H, Deaton RJ, Mo F, Sverdlov M, Gann PH, Sinha S, Sahni S, Wang K, Van Bortle K, Tajkorshid E, Woodward WA, Cho W, Nelson ER.   +31 more
europepmc   +1 more source

The emerging role of the Hippo signaling pathway in interorgan crosstalk

The FEBS Journal, EarlyView.
Hippo signaling functions as a central hub of interorgan communication. Systemic cues from the gut, adipose tissue, and skeletal muscle—including hormones, metabolites, and microbial signals—regulate YAP/TAZ activity in a tissue‐ and context‐dependent manner.
Gahyeon Song, Chaerin Lee, Eek‐hoon Jho   +2 more
wiley   +1 more source

Chicoric acid enhanced brain cholesterol efflux and reduced Aβ pathology via LXR-ABCA1 signaling in Alzheimer's models. [PDF]

Neurotherapeutics
Li D, Zhang Y, Wang R, Jin L, Cui X, Hong JS, Li S, Zhao J, Guo Y.   +8 more
europepmc   +1 more source

Cholesterol accumulation in monocytes is associated with the severity of diabetic complications and the efficacy of glycemic control interventions in patients with type 2 diabetes

Journal of Diabetes Investigation, EarlyView.
This study reveals that monocyte cholesterol accumulation correlates with the severity of diabetic complications and predicts post‐discharge glycemic deterioration. These findings suggest that monocytic cholesterol serves as a novel translational biomarker reflecting ‘metabolic memory’ and therapeutic resistance in patients with type 2 diabetes ...
Hideyuki Okuma, Takahiro Tsutsumi, Asako Miyazaki, Kyoichiro Tsuchiya   +3 more
wiley   +1 more source

Diabetic kidney disease macrophage cholesterol efflux: a revolution from metabolism to immune. [PDF]

Front Endocrinol (Lausanne)
Wang J, Cai Y, Feng Y, Zhu Q.
europepmc   +1 more source

Glycosphingolipid accumulation inhibits cholesterol efflux via the ABCA1/apolipoprotein A-I pathway: 1-Phenyl-2-decanoylamino-3-morpholino-1- propanol is a novel cholesterol efflux accelerator

, 2005
Cellular glycosphingolipid (GSL) storage is known to promote cholesterol accumulation. Although physical interactions between GSLs and cholesterol are thought to cause intracellular cholesterol "trapping," it is not known whether cholesterol homeostatic ...
Elias N Glaros (20205426), C M Quinn (20211603), Jenny Wong (20119995), Brett Garner (20122005), I C Gelissen (20211606), W Jessup (13726693), W B Kim (20211600)   +6 more
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