Results 41 to 50 of about 82,690 (331)

Predictive value of HDL function in patients with coronary artery disease: relationship with coronary plaque characteristics and clinical events

Annals of Medicine, 2022
Background HDL is endowed with several metabolic, vascular, and immunoinflammatory protective functions. Among them, a key property is to promote reverse cholesterol transport from cells back to the liver.
Marco Magnoni, Daniele Andreini, Angela Pirillo, Patrizia Uboldi, Roberto Latini, Alberico L. Catapano, Aldo P. Maggioni, Giuseppe D. Norata   +7 more
doaj   +1 more source

SR-BI inhibits ABCG1-stimulated net cholesterol efflux from cells to plasma HDL

Journal of Lipid Research, 2008
This study compares the roles of ABCG1 and scavenger receptor class B type I (SR-BI) singly or together in promoting net cellular cholesterol efflux to plasma HDL containing active LCAT. In transfected cells, SR-BI promoted free cholesterol efflux to HDL,
Laurent Yvan-Charvet, Tamara A. Pagler, Nan Wang, Takafumi Senokuchi, May Brundert, Hongna Li, Franz Rinninger, Alan R. Tall   +7 more
doaj   +1 more source

Overexpression and deletion of phospholipid transfer protein reduce HDL mass and cholesterol efflux capacity but not macrophage reverse cholesterol transport

Journal of Lipid Research, 2017
Phospholipid transfer protein (PLTP) may affect macrophage reverse cholesterol transport (mRCT) through its role in the metabolism of HDL. Ex vivo cholesterol efflux capacity and in vivo mRCT were assessed in PLTP deletion and PLTP overexpression mice ...
Takashi Kuwano, Xin Bi, Eleonora Cipollari, Tomoyuki Yasuda, William R. Lagor, Hannah J. Szapary, Junichiro Tohyama, John S. Millar, Jeffrey T. Billheimer, Nicholas N. Lyssenko, Daniel J. Rader   +10 more
doaj   +1 more source

Apolipoprotein E and Atherosclerosis: From Lipoprotein Metabolism to MicroRNA Control of Inflammation. [PDF]

, 2018
Apolipoprotein (apo) E stands out among plasma apolipoproteins through its unprecedented ability to protect against atherosclerosis. Although best recognized for its ability to mediate plasma lipoprotein clearance in the liver and protect against ...
Hasty, Hui, Hussain, Lin, Mahley, Pepe, Roselaar   +6 more
core   +2 more sources

Apolipoprotein E-dependent cholesterol efflux from macrophages: kinetic study and divergent mechanisms for endogenous versus exogenous apolipoprotein E

Journal of Lipid Research, 1999
In these studies, we have utilized a J774 macrophage model in order to compare phospholipid and cholesterol efflux kinetics in macrophage cells that do not express endogenous apoE to cells transfected to express physiologic levels of human apoE.
Chen-Yi Lin, Hongwei Duan, Theodore Mazzone   +2 more
doaj   +1 more source

The cardiovascular phenotype of adult patients with phenylketonuria [PDF]

, 2019
BACKGROUND: Patients with Phenylketonuria (PKU) are exposed to multiple cardiovascular risk factors, but the clinical significance of these abnormalities is yet unknown.
Azabdaftari, Aline, Giet, Markus van der, Hennermann, Julia B., Plöckinger, Ursula, Querfeld, Uwe, Schuchardt, Mirjam   +5 more
core   +1 more source

The cholesterol 24-hydroxylase activates autophagy and decreases mutant huntingtin build-up in a neuroblastoma culture model of Huntington’s disease [PDF]

, 2020
Objective Compromised brain cholesterol turnover and altered regulation of brain cholesterol metabolism have been allied with some neurodegenerative diseases, including Huntington’s disease (HD).
Alves, Sandro, Betuing, Sandrine, Caboche, Jocelyne, Carmo-Silva, Sara, Cartier, Nathalie, Conceição, André, Costa, Rafael G, Koppenol, Rebekah, Marcelo, Adriana, Matos, Carlos A, Nunes, Ricardo, Nóbrega, Clévio, Sequeira, Raquel L.   +12 more
core   +1 more source

Sphingomyelin-dependence of cholesterol efflux mediated by ABCG1s⃞

Journal of Lipid Research, 2007
ABCG1, one of the half-type ATP binding cassette (ABC) proteins, mediates the efflux of cholesterol to HDL and functions in the reverse cholesterol transport from peripheral cells to the liver.
Osamu Sano, Aya Kobayashi, Kohjiro Nagao, Keigo Kumagai, Noriyuki Kioka, Kentaro Hanada, Kazumitsu Ueda, Michinori Matsuo   +7 more
doaj   +1 more source

Proteomic analysis of HDL from inbred mouse strains implicates APOE associated with HDL in reduced cholesterol efflux capacity via the ABCA1 pathway[S]

Journal of Lipid Research, 2016
Cholesterol efflux capacity associates strongly and negatively with the incidence and prevalence of human CVD. We investigated the relationships of HDL's size and protein cargo with its cholesterol efflux capacity using APOB-depleted serum and HDLs ...
Nathalie Pamir, Patrick Hutchins, Graziella Ronsein, Tomas Vaisar, Catherine A. Reardon, Godfrey S. Getz, Aldons J. Lusis, Jay W. Heinecke   +7 more
doaj   +1 more source

Oxysterol-Binding Protein-1 (OSBP1) Modulates Processing and Trafficking of the Amyloid Precursor Protein [PDF]

, 2008
BACKGROUND Evidence from biochemical, epidemiological and genetic findings indicates that cholesterol levels are linked to amyloid-β (Aβ) production and Alzheimer's disease (AD). Oxysterols, which are cholesterol-derived ligands of the liver X receptors
Abraham, Carmela R., Chen, Ci-Di, Cordy, Joanna M., Guillily, Maria, Ray, William J., Seabrook, Guy R., Suon, Sokreine, Wolozin, Benjamin, Zerbinatti, Celina V.   +8 more
core   +4 more sources