Results 161 to 170 of about 53,815 (207)

Cholesterol Ester Transfer Protein (CETP), Postprandial Lipemia and Hypolipidemic Drugs

Current Medicinal Chemistry, 2009
Cholesterol ester transfer protein (CETP) plays a significant role in high density lipoprotein (HDL) metabolism and reverse cholesterol transport (RCT). A reduction in CETP activity leads to an increase in HDL-cholesterol levels. However, the relationship between reduced CETP function and atherosclerosis is complex and confusing.
G D, Kolovou, K K, Anagnostopoulou, P M, Kostakou, D P, Mikhailidis   +3 more
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Genetic Variations of Cholesterol Ester Transfer Protein Gene in Koreans

Human Biology, 2001
An absence of cholesterol ester transfer protein (CETP, protein; CETP, gene) results in an increase of the apolipoprotein AI levels and a decrease in the low density lipoprotein (LDL) levels. Thus, the CETP polymorphism is important in the assessment of risk of atherosclerosis.
S H, Hong, Y R, Kim, J, Song, J Q, Kim
openaire   +2 more sources

Cholesteryl Ester Transfer Protein Mutations, Protein Activity and HDL-Cholesterol Concentration

cclm, 1998
Abstract We have examined a group of North American subjects, selected to include individuals with a wide variety of HDL-cholesterol concentrations for: 1) mutations in the genes coding for cholesteryl ester transfer protein and hepatic lipase, 2) apolipoprotein E genotype, 3) total cholesterol and triglycerides, 4) HDL-triglycerides ...
S A, Hill, C, Thomson, M J, McQueen
openaire   +2 more sources

New Horizons for Cholesterol Ester Transfer Protein Inhibitors

Current Atherosclerosis Reports, 2011
High-density lipoprotein (HDL) cholesterol levels bear an inverse relationship to cardiovascular risk. To date, however, no intervention specifically targeting HDL has been demonstrated to reduce cardiovascular risk. Cholesterol ester transfer protein (CETP) mediates transfer of cholesterol ester from HDL to apolipoprotein B-containing particles. Most,
openaire   +2 more sources

The Effects of Cholesterol Ester Transfer Protein Inhibition on Cholesterol Efflux

The American Journal of Cardiology, 2009
Cholesterol ester transfer protein (CETP) deficiency or inhibition results in dramatic elevations of high-density lipoprotein (HDL) levels, but there has been concern that HDL might be dysfunctional in its ability to promote efflux of cholesterol from macrophage foam cells or to mediate reverse cholesterol transport.
openaire   +2 more sources

Cholesteryl ester transfer protein inhibition by PD 140195

Lipids, 1994
AbstractThe presence of plasma cholesteryl ester transfer protein (CETP) activity may be atherogenic, and, therefore, strategies to inhibit its activity or production may result in a beneficial effect on lipoprotein profiles and the disease process. The current report describes 4‐phenyl‐5‐tridecyl‐4H‐1,2,4‐triazole‐3‐thiol (PD 140195), a novel CETP ...
C L, Bisgaier, A D, Essenburg, L L, Minton, R, Homan, C J, Blankley, A, White   +5 more
openaire   +2 more sources

Cholesterol ester transfer protein: a therapeutic target in atherosclerosis?

Expert Opinion on Therapeutic Targets, 2008
CETP has an established role in the transport of cholesterol from the peripheral tissues to the liver for elimination. The fact that CETP was recognized as a target for raising high-density lipoprotein cholesterol (HDL-C) levels has led to research on CETP inhibitors to protect against atherosclerosis.To review the role of CETP as a pivotal target for ...
Ekaterini, Vourvouhaki, George V, Dedoussis   +1 more
openaire   +2 more sources

Cholesterol Ester Transfer Protein: A Molecule with Three Faces?

Critical Reviews in Clinical Laboratory Sciences, 1998
The pathogenesis of atherosclerosis continues to be a focus of intensive study. One of the more recent players in the atherosclerosis drama is cholesterol ester transfer protein (CETP). CETP is primarily involved in lipid transfer between lipoproteins, for example, from high-density lipoproteins (HDL) to apo B-containing lipoproteins, but CETP has also
openaire   +2 more sources

Reverse cholesterol transport in mice expressing simian cholesteryl ester transfer protein

Atherosclerosis, 2002
The role of cholesteryl ester transfer protein (CETP) in atherogenesis remains ambiguous, as both pro and antiatherogenic effects have been described. Expression of CETP increases HDL-cholesteryl ester turnover, but there is no direct evidence whether CETP mobilizes cholesterol in vivo.
O, Stein, Y, Dabach, G, Hollander, M, Ben-Naim, G, Halperin, Y, Stein   +5 more
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Peroxisome Proliferator‐Activated Receptor α Agonists Regulate Cholesterol Ester Transfer Protein

Lipids, 2008
AbstractPeroxisome proliferator‐activated receptor α (PPARα) belongs to the nuclear receptor superfamily that regulates multiple target genes involved in lipid metabolism. Cholesterol ester transfer protein (CETP) is a secreted glycoprotein that modifies high‐density lipoprotein (HDL) particles.
Thomas P, Beyer, Yanqun, Chen, Regina K, Porter, Deshun, Lu, Robert J, Schmidt, Nathan B, Mantlo, Robert J, Konrad, Guoqing, Cao   +7 more
openaire   +2 more sources