Results 171 to 180 of about 53,815 (207)
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Potential Inhibitors of the Activity of the Cholesterol-Ester Transfer Protein
Journal of Computational Biology, 2019The cholesterol-ester transfer protein (CETP) exchanges lipids between high-density lipoproteins (HDLs) and low-density lipoproteins (LDLs). The excessive transport of lipids from HDLs to LDLs mediated by this protein can cause an alteration in the deposition of lipoproteins onto the arterial walls, thus promoting the development of arteriosclerosis ...
Tarraga, Wilson Alberto +3 more
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1989
More than 80% of the cholesteryl esters (CE) found in human plasma derive from the reaction of lecithin: cholesterol acyl transferase (LCAT). Since the content of CE in plasma high positively correlates with the incidence of atherosclerosis and myocardial infarction, there has been in the past and still is great interest in investigation of the enzymes
G. M. Kostner, E. Steyrer
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More than 80% of the cholesteryl esters (CE) found in human plasma derive from the reaction of lecithin: cholesterol acyl transferase (LCAT). Since the content of CE in plasma high positively correlates with the incidence of atherosclerosis and myocardial infarction, there has been in the past and still is great interest in investigation of the enzymes
G. M. Kostner, E. Steyrer
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Canadian journal of physiology and pharmacology, 2007
We investigated whether expression of cholesterol ester transfer protein (CETP) in mice alters the regulation of cholesterol metabolism. Transgenic mice expressing human CETP (CETP-TG) and nontransgenic littermates (non-TG) were fed either a monounsaturated fatty acid (MUFA) or a saturated fatty acid (SFA)-rich diet in the presence or absence of ...
Alka, Agarwal-Mawal +3 more
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We investigated whether expression of cholesterol ester transfer protein (CETP) in mice alters the regulation of cholesterol metabolism. Transgenic mice expressing human CETP (CETP-TG) and nontransgenic littermates (non-TG) were fed either a monounsaturated fatty acid (MUFA) or a saturated fatty acid (SFA)-rich diet in the presence or absence of ...
Alka, Agarwal-Mawal +3 more
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Effects of an Inhibitor of Cholesteryl Ester Transfer Protein on HDL Cholesterol
New England Journal of Medicine, 2004Decreased high-density lipoprotein (HDL) cholesterol levels constitute a major risk factor for coronary heart disease; however, there are no therapies that substantially raise HDL cholesterol levels. Inhibition of cholesteryl ester transfer protein (CETP) has been proposed as a strategy to raise HDL cholesterol levels.We conducted a single-blind ...
Margaret E, Brousseau +7 more
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[HDL and reverse cholesterol transport. Role of cholesterol ester transfer protein].
Comptes rendus des seances de la Societe de biologie et de ses filiales, 1993As most of peripheral cells are not able to catabolize cholesterol, the transport of cholesterol excess from peripheral tissues back to the liver, namely "reverse cholesterol transport", is the only way by which cholesterol homeostasis is maintained in vivo.
L, Lagrost, P, Gambert
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[Cholesterol ester transfer protein (CETP)].
Nihon rinsho. Japanese journal of clinical medicine, 1995Plasma CETP plays an important role in the reverse cholesterol transport system in conjunction with lecithin:cholesterol acyltransferase (LCAT). CETP mediates transfer of cholesteryl ester from HDL to apo B containing lipoproteins and also mediates transfer of triglyceride from VLDL and IDL to HDL.
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The Pharmacology and Off-Target Effects of Some Cholesterol Ester Transfer Protein Inhibitors
The American Journal of Cardiology, 2009Inhibitors of cholesterol ester transfer protein (CETP) have the capacity to increase plasma high-density lipoprotein cholesterol to unprecedented levels. Still, hopes that CETP inhibition could reduce atherosclerosis were dented when the clinical development of one such inhibitor, torcetrapib, was halted because of an unexpected finding of increased ...
Vergeer, Menno, Stroes, Erik S. G.
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The cholesterol ester transfer protein inhibitor, anacetrapib
Current Opinion in Lipidology, 2011Ishwarlal, Jialal, Jaspreet, Kaur
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1988
Early work by Rehnborg and Nichols (1) showed that upon incubation of normolipemic plasma, cholesteryl ester (CE) concentration increased in VLDL, LDL and HDL whereas triglycerides (TG) concentration decreased in VLDL and increased in LDL and HDL. These experiments (1,2) were the first to document CE transfer between lipoproteins but the concept was ...
Y L, Marcel +5 more
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Early work by Rehnborg and Nichols (1) showed that upon incubation of normolipemic plasma, cholesteryl ester (CE) concentration increased in VLDL, LDL and HDL whereas triglycerides (TG) concentration decreased in VLDL and increased in LDL and HDL. These experiments (1,2) were the first to document CE transfer between lipoproteins but the concept was ...
Y L, Marcel +5 more
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[Cholesterol ester transfer protein. A major player in cholesterol metabolism].
Ugeskrift for laeger, 1999Plasma cholesterol transfer protein (P-CETP) plays a central role in cholesterol metabolism by pronroting transfer of cholesteryl esters from high density lipoprotein (HDL) to very low density lipoproteins in exchange for triglycerides. The CETP-reaction may hereby be a critical factor in reverse cholesterol transport, i.e., the transfer of cholesterol
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