Results 71 to 80 of about 53,815 (207)

Anacetrapib reduces (V)LDL cholesterol by inhibition of CETP activity and reduction of plasma PCSK9[S]

Journal of Lipid Research, 2015
Recently, we showed in APOE*3-Leiden cholesteryl ester transfer protein (E3L.CETP) mice that anacetrapib attenuated atherosclerosis development by reducing (V)LDL cholesterol [(V)LDL-C] rather than by raising HDL cholesterol.
Sam J.L. van der Tuin, Susan Kühnast, Jimmy F.P. Berbée, Lars Verschuren, Elsbet J. Pieterman, Louis M. Havekes, José W.A. van der Hoorn, Patrick C.N. Rensen, J. Wouter Jukema, Hans M.G. Princen, Ko Willems van Dijk, Yanan Wang   +11 more
doaj   +1 more source

Elevation of plasma phospholipid transfer protein increases the risk of atherosclerosis despite lower apolipoprotein B-containing lipoproteins. [PDF]

, 2004
Plasma phospholipid transfer protein (PLTP) transfers phospholipids between lipoproteins and mediates HDL conversion. PLTP-overexpressing mice have increased atherosclerosis.
Arai, Arie van Tol, Barter, Barter, Bruce, De Geest, Delsing, Ehnholm, Farah Sadeghi-Niaraki, Fielding, Forte, Föger, Herrera, Huuskonen, Jauhiainen, Jessica Lie, Jiang, Jiang, Jiang, Kawano, Leo Scheek, Libby, Lie, Lie, Mackness, Marotti, Mason, Okamoto, Plump, Qin, Quarck, Redgrave, Rien van Haperen, Rini de Crom, Rodrigo, Rye, Shih, Speijer, Tall, Teus van Gent, Tselepis, Tu, Tward, Van Haperen, Van Tol, Van Tol, Watson, Wolfbauer   +47 more
core   +3 more sources

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease

Redox Biology, 2017
Niemann Pick type C (NPC) disease is a progressive lysosomal storage disorder caused by mutations in genes encoding NPC1/NPC2 proteins, characterized by neurological defects, hepatosplenomegaly and premature death.
Sandra Torres, Nuria Matías, Anna Baulies, Susana Nuñez, Cristina Alarcon-Vila, Laura Martinez, Natalia Nuño, Anna Fernandez, Joan Caballeria, Thierry Levade, Alba Gonzalez-Franquesa, Pablo Garcia-Rovés, Elisa Balboa, Silvana Zanlungo, Gemma Fabrías, Josefina Casas, Carlos Enrich, Carmen Garcia-Ruiz, José C. Fernández-Checa   +18 more
doaj   +1 more source

Ethanol Induced Disordering of Pancreatic Acinar Cell Endoplasmic Reticulum: An ER Stress/Defective Unfolded Protein Response Model. [PDF]

, 2018
Background & aimsHeavy alcohol drinking is associated with pancreatitis, whereas moderate intake lowers the risk. Mice fed ethanol long term show no pancreas damage unless adaptive/protective responses mediating proteostasis are disrupted. Pancreatic
Abrol, Ravinder, Capri, Joseph, Cohn, Whitaker, Faull, Kym F, Freeman, Michael R, Lugea, Aurelia, Pandol, Stephen J, Piplani, Honit, Sakkiah, Sugunadevi, Su, Hsin-Yuan, Waldron, Richard T, Whitelegge, Julian P, Yang, Wei, Zhou, Bo   +13 more
core   +3 more sources

The Development of a Direct Homologous Radioimmunoassay for Serum Cortisol [PDF]

, 1981
Peer ...
Giesemann, G., Müller, O. A., Scriba, Peter Christian, Stalla, G., Wood, W. G.   +4 more
core   +2 more sources

ApoE-containing high density lipoproteins and phospholipid transfer protein activity increase in patients with a systemic inflammatory response

Journal of Lipid Research, 2001
High density lipoproteins (HDL) mediate reverse cholesterol transport as well as the clearance of oxidation products or inflammatory mediators, thereby contributing to tissue integrity. The decrease in HDL in inflammation has been attributed to decreased
Stefan Barlage, Dieter Fröhlich, Alfred Böttcher, Matti Jauhiainen, Hans Peter Müller, Felicitas Noetzel, Gregor Rothe, Christine Schütt, Reinhold P. Linke, Karl J. Lackner, Christian Ehnholm, Gerd Schmitz   +11 more
doaj   +1 more source

A Systematic Approach to Identifying Protein-Ligand Binding Profiles on a Proteome Scale [PDF]

, 2008
Identification of protein-ligand interaction networks on a proteome scale is crucial to address a wide range of biological problems such as correlating molecular functions to physiological processes and designing safe and efficient therapeutics.
Lei Xie, Li Xie, Nancy Buchmeier, Philip Bourne   +3 more
core   +2 more sources

Expression of Cholesteryl Ester Transfer Protein in Mice Promotes Macrophage Reverse Cholesterol Transport [PDF]

Circulation, 2007
Background— Cholesteryl ester transfer protein (CETP) transfers cholesteryl esters from high-density lipoproteins to apolipoprotein (apo) B–containing lipoproteins and in humans plays an important role in lipoprotein metabolism.
Hiroyuki, Tanigawa, Jeffrey T, Billheimer, Jun-ichiro, Tohyama, YuZhen, Zhang, George, Rothblat, Daniel J, Rader   +5 more
openaire   +2 more sources

Association of CETP TaqI and APOE polymorphisms with type II diabetes mellitus in North Indians: a case control study

BMC Endocrine Disorders, 2005
Background Genetic variants of proteins involved in lipid metabolism may play an important role in determining the susceptibility for complications associated with type II diabetes mellitus (T2DM).
Mittal Balraj, Bhattacharya Sandeep, Dixit Manjusha   +2 more
doaj   +1 more source