Results 201 to 210 of about 93,050 (306)

Postpartum lipid dysregulation in African American women who experienced cardiometabolic complications of pregnancy. [PDF]

iScience
Maner-Smith K, Chen CY, Hou Z, Gulbin XL, Ahn J, Ortlund EA, Dunlop AL, Ferranti E.   +7 more
europepmc   +1 more source

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

Phytotherapy Research, EarlyView.
ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley   +1 more source

Lipid management in type 2 diabetes and non-HDL-cholesterol: target all atherogenic lipoproteins. [PDF]

Cardiovasc Diabetol
Brandts J, Verket M, Zambon A, Marx N, Müller-Wieland D, Federici M.   +5 more
europepmc   +1 more source

Microglial Activation Under Hypoxic Conditions in Early Alzheimer's Disease: Can Natural SIRT1 Activators Be Therapeutic Allies in the Inflammation–Energy Axis?

Phytotherapy Research, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by a preclinical stage that typically lasts for decades. Early on during this time, microglia react to pathological changes and become protective and even transiently delay neurodegeneration.
Sara Merlo, Cristiana Lucia Rita Lipari, Aurora Patti, Maria Angela Sortino   +3 more
wiley   +1 more source

Gene-metabolite interactions in aortic dissection: Insights from metabolic and single-cell analyses. [PDF]

Medicine (Baltimore)
Yao C, Wang G, Wu Q, Pan Y, Chen Z, Guo J, Lin C, Peng Y, Li X.   +8 more
europepmc   +1 more source

Innovative γ‐Oryzanol and KC2 Based Lipid Nanoparticles: OryKL Platform Provides Safe and Efficient In Vivo mRNA Delivery

Small, EarlyView.
Identified through multi‐stage selection process, a formulation combining γ‐oryzanol and DLin‐KC2‐DMA, termed as OryKL, demonstrates unique nano‐structural features, highly efficient mRNA transfection and functional integrity during long‐term storage, enables broad biodistribution and distinct cell tropism following intravenous administration with no ...
Pengkai Shi, Haikun Liu, Ahmed Refaat, Hung Nguyen, Anne Nguyen, Kaiting Miao, Yuyang Song, Sylvain Trépout, Rico F. Tabor, Liliana de Campo, Karlheinz Peter, Mark Louis P. Vidallon, Xiaowei Wang   +12 more
wiley   +1 more source

ACAT-1, Cav-1 and PrP expression in scrapie susceptible and resistant sheep

Open Life Sciences, 2010
Orrù Cristina, Abete Claudia, Dolores Cannas M., Mulas Claudia, Norfo Claudia, Mandas Antonella, Vascellari Sarah, Colla Paolo, Dessì Sandra, Pani Alessandra   +9 more
doaj   +1 more source

Causal effects of glutamine and lipid-related metabolites on alopecia areata: A 2-sample Mendelian randomization study. [PDF]

Medicine (Baltimore)
Yang XS, Dai R, Miao YJ, Chen SZ, Lv ZF.
europepmc   +1 more source

Photo‐induced proton release of spiropyran‐derived nanomaterials for mRNA delivery in hard‐to‐transfect cells

Smart Molecules, EarlyView.
Light‐induced proton release from spiropyran can disrupt the stability of both nanoparticles and endosomal membranes, thereby promoting endosomal escape and ultimately enhancing transfection performance. Abstract Messenger RNA (mRNA) therapy has been explored as a treatment for various genetic disorders. Significant progress has been made in developing
Caiwei Lu, Zhiwei Zhou, Leilei Li, Zhu Yu, Feiyu Chen, Yi Xiao, Xinfu Zhang   +6 more
wiley   +1 more source

Bisphenols and Phthalates in Bottled Mineral Water: First Evidence of Co‐Occurrence, Estrogenic Activity, and Health Risk in Brazil

Environmental Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA), its structural analogs, and phthalates are synthetic chemicals widely used, with documented endocrine‐disrupting activity. This study aimed to develop and validate a selective multiresidue analytical method for the simultaneous determination of BPA, 10 bisphenol analogs, and six phthalates in PET‐bottled mineral water.
Giulia Boito Reyes, Lucas Correia Gonçalves, Fernanda Cristina Iba Molinari, José Eduardo Gonçalves   +3 more
wiley   +1 more source