Results 51 to 60 of about 1,222,670 (353)

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Effect of large doses of the oral contraceptive Enovid on cholesterol metabolism in the rat

Journal of Lipid Research, 1968
Short-term effects of the oral contraceptive drug, Enovid, a mixture of estrogenic and progesterone compounds, have been determined in experiments on male and female rats.
Lilla Aftergood, H. Joseph Hernandez, Roslyn B. Alfin-Slater   +2 more
doaj   +1 more source

The cholesterol ester cycle regulates signalling complexes and synapse damage caused by amyloid-ß [PDF]

, 2017
Cholesterol is required for the formation and function of some signalling platforms. In synaptosomes, amyloid-β (Aβ) oligomers, the causative agent in Alzheimer's disease, bind to cellular prion proteins (PrPC) resulting in increased cholesterol ...
Anderson, Bate, Bate, Bate, Baxter, Bryleva, Chan, Chang, Chen, Chen, Chiarini, Chiesa, Dunkley, Gaudreault, Gilch, Giuffrida, Gocze, Gylys, Hammond, Herms, Hosie, Kaneko, Kawarabayashi, Koch, Laurén, Linden, Linetti, Lingwood, Lingwood, London, Maglio, Maxfield, Mc Donald, McLean, Montine, Moskowitz, Mouillet-Richard, Nalefski, Naslavsky, Osborne, Pani, Puglielli, Rajendran, Robinet, Ryan, Schroeder, Selkoe, Shankar, Sharma, Simons, Solforosi, Stahl, Sugiyama, Suzuki, Taraboulos, Walsh, Williamson, Yang   +57 more
core   +2 more sources

Electrosynthesis of Bioactive Chemicals, From Ions to Pharmaceuticals

Advanced Functional Materials, EarlyView.
This review discusses recent advances in electrosynthesis for biomedical and pharmaceutical applications. It covers key electrochemical materials enabling precise delivery of ions and small molecules for cellular modulation and disease treatment, alongside catalytic systems for pharmaceutical synthesis.
Gwangbin Lee, Sojin Kim, Myeongeun Lee, Kyoungsuk Jin, Jimin Park   +4 more
wiley   +1 more source

Separation and identification of triglycerides, cholesteryl esters, cholesterol, 7-dehydrocholesterol, dolichol, ubiquinone, alpha-tocopherol, and retinol by high performance liquid chromatography with a diode array detector

Journal of Lipid Research, 1988
A simple isocratic high performance liquid chromatography (HPLC) system is described that allows separation and identification of cholesteryl esters, triglycerides, ubiquinone, alpha-tocopherol, dolichol, cholesterol, 7-dehydrocholesterol, and retinol ...
M D Greenspan, C Y Lo, D P Hanf, J B Yudkovitz   +3 more
doaj   +1 more source

RNA‐Micelles as Self‐Assembling Structures for Efficient Co‐Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis

Advanced Functional Materials, EarlyView.
Two kinds of self‐assembled RNA micelles were used to co‐deliver synergistic siRNA and nucleoside analogues for the treatment of colorectal cancer lung metastases. Near‐complete elimination of lung cancer metastases was confirmed in an orthotopic lung metastasis model constructed using human colorectal cancer lung metastases patient surgical samples to
Kai Jin, Piotr Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo   +4 more
wiley   +1 more source

Purification of neutral lipid fractions by thin-layer chromatography on aluminum oxide

Journal of Lipid Research, 1965
Two-stage thin-layer chromatography on Aluminum Oxide G has been used to separate triglycerides, cholesterol, cholesterol esters, and diglycerides from contaminating fatty acids present in the lipid mixtures.
J.M. Lederkremer, Ralph M. Johnson
doaj   +1 more source

Evidence suggesting that di-n-butyl phthalate has anti-androgenic effects in fish [PDF]

, 2011
This article is the pre-print version of the full and final published article.Phthalate ester plasticizers are anti-androgenic in mammals. High doses of certain phthalates consistently interfere with the normal development of male offspring exposed in ...
Adams, Akingbemi, Autian, Bjorkblom, Borch, Culty, Dargnat, Filby, Foster, Fromme, Graham, Gray, Han, Harries, Horn, Jobling, Jobling, Jobling, Jolly, Katsiadaki, Katsiadaki, Kim, Lee, Lehmann, Liu, Loraine, Mackintosh, McCurley, Moore, Ogunfowokan, Pfaffl, Schettler, Scott, Scott, Sebire, Shen, Staples, Uren-Webster, Vethaak, Villeneuve   +39 more
core   +1 more source

The Rabbit 15-Lipoxygenase Preferentially Oxygenates LDL Cholesterol Esters, and This Reaction Does Not Require Vitamin E*

Journal of Biological Chemistry, 1998
The oxidation of low density lipoprotein (LDL) by mammalian 15-lipoxygenases (15-LOX) was implicated in early atherogenesis. We investigated the molecular mechanism of 15-LOX/LDL interaction and found that during short term incubations, LDL cholesterol ...
J. Belkner, H. Stender, H. Kühn
semanticscholar   +1 more source

Liquid Crystalline Inverted Lipid Phases and Reverse Micelles in Drug Delivery: From Molecular Design to Therapeutic Potential

Advanced Functional Materials, EarlyView.
Liquid crystalline inverted lipid phases and reverse micelles are self‐assembled lipid nanostructures that enhance the solubility, stability, and delivery of diverse therapeutics. This review integrates their physicochemical principles, formulation strategies, drug loading mechanisms, and biomedical applications, highlighting their growing ...
Numan Eczacioglu, Mulazim Hussain Asim, Soheil Haddadzadegan, Andreas Bernkop‐Schnürch   +3 more
wiley   +1 more source