Results 1 to 10 of about 441,731 (309)

Glutamine sensing licenses cholesterol synthesis. [PDF]

EMBO J
AbstractThe mevalonate pathway produces essential lipid metabolites such as cholesterol. Although this pathway is negatively regulated by metabolic intermediates, little is known of the metabolites that positively regulate its activity. We found that the amino acid glutamine is required to activate the mevalonate pathway. Glutamine starvation inhibited
Garcia BM, Melchinger P, Medeiros T, Hendrix S, Prabhu K, Corrado M, Kingma J, Gorbatenko A, Deshwal S, Veronese M, Scorrano L, Pearce E, Giavalisco P, Zelcer N, Pernas L.   +14 more
europepmc   +8 more sources

Intracellular Cholesterol Synthesis and Transport. [PDF]

Front Cell Dev Biol, 2022
Cholesterol homeostasis is related to multiple diseases in humans, including cardiovascular disease, cancer, and neurodegenerative and hepatic diseases. The cholesterol levels in cells are balanced dynamically by uptake, biosynthesis, transport, distribution, esterification, and export.
Shi Q, Chen J, Zou X, Tang X.
europepmc   +4 more sources

A Transient Inflammatory Response Induced by Lipopolysaccharide Infusion Lowers Markers of Endogenous Cholesterol and Bile Acid Synthesis in Healthy Normocholesterolemic Young Men

Biomedicines, 2023
Inflammation is associated with changes in plasma lipids, lipoproteins, and cholesterol efflux capacity (CEC). It is unknown if the changes in lipids and lipoproteins during inflammation are related to changes in cholesterol absorption, synthesis, and ...
Sultan Mashnafi, Sabine Baumgartner, Ronald P. Mensink, Desiree Perlee, Lonneke A. van Vught, Dieter Lütjohann, Jogchum Plat   +6 more
doaj   +1 more source

Besnoitia besnoiti infection alters both endogenous cholesterol de novo synthesis and exogenous LDL uptake in host endothelial cells [PDF]

, 2008
Besnoitia besnoiti, an apicomplexan parasite of cattle being considered as emergent in Europe, replicates fast in host endothelial cells during acute infection and is in considerable need for energy, lipids and other building blocks for offspring ...
Silva, Liliana M. R., Lütjohann, Dieter, Hamid, Penny, Velasquez, Zahady D., Kerner, Katharina, Larrazabal, Camilo, Failing, Klaus, Hermosilla, Carlos, Taubert, Anja   +8 more
core   +2 more sources

Steroidal Triterpenes of Cholesterol Synthesis [PDF]

Molecules, 2013
Cholesterol synthesis is a ubiquitous and housekeeping metabolic pathway that leads to cholesterol, an essential structural component of mammalian cell membranes, required for proper membrane permeability and fluidity. The last part of the pathway involves steroidal triterpenes with cholestane ring structures.
Ačimovič, Jure, Rozman, Damjana
openaire   +4 more sources

Inheritance of cholesterol metabolism of probands with high or low cholesterol absorption

Journal of Lipid Research, 2002
Heredity of cholesterol absorption and synthesis was studied in siblings of hypercholesterolemic probands with low and high serum cholestanol to cholesterol ratio (assumed to indicate low and high absorption of cholesterol, respectively).
Helena Gylling, Tatu A. Miettinen
doaj   +1 more source

Effects of ursodeoxycholic acid on synthesis of cholesterol and bile acids in healthy subjects [PDF]

, 2004
Background/Aims: Ursodeoxycholic acid ( UDCA) decreases biliary secretion of cholesterol and is therefore used for the dissolution of cholesterol gallstones.
Fischer, S., Jungst, C., Jungst, D., Parhofer, K. G., Sauter, G. H., Thiessen, K.   +5 more
core   +1 more source

Statins increase hepatic cholesterol synthesis and stimulate fecal cholesterol elimination in mice

Journal of Lipid Research, 2016
Statins are competitive inhibitors of HMG-CoA reductase, the rate-limiting enzyme of cholesterol synthesis. Statins reduce plasma cholesterol levels, but whether this is actually caused by inhibition of de novo cholesterol synthesis has not been clearly ...
Marleen Schonewille, Jan Freark de Boer, Laura Mele, Henk Wolters, Vincent W. Bloks, Justina C. Wolters, Jan A. Kuivenhoven, Uwe J.F. Tietge, Gemma Brufau, Albert K. Groen   +9 more
doaj   +1 more source

Synthesis of the oxysterol, 24(S), 25-epoxycholesterol, parallels cholesterol production and may protect against cellular accumulation of newly-synthesized cholesterol

Lipids in Health and Disease, 2007
Aim The effects of 24(S),25-epoxycholesterol (24,25EC) on aspects of cholesterol homeostasis is well-documented. When added to cells, 24,25EC decreases cholesterol synthesis and up-regulates cholesterol efflux genes, including ABCA1. Synthesis of 24,25EC
Brown Andrew J, Quinn Carmel M, Wong Jenny   +2 more
doaj   +1 more source

Effects of 3-Hydroxy-3-methylglutaryl-CoA Reductase Inhibitors on Cholesterol Metabolism in Laying Hens

Animals, 2023
This study aimed to investigate the effect of HMGCR inhibitors on egg yolk cholesterol content and its biological mechanisms. Four groups of 180-day-old laying hens (n = 8 cages/group, 6 laying hens/cage) were fed a corn/soybean-based diet (control) and ...
Huanbin Wang, Kuntan Wu, Xiaomei Mi, Shahid Ali Rajput, Desheng Qi   +4 more
doaj   +1 more source