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Intracellular cholesterol transport
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1999The intracellular movement of cholesterol in mam- malian cells may involve complex pathways by which the sterol moves to various cellular sites and mediates transcriptional regu- lation, enzyme activation, and protein degradation. Current evidence indicates that there are three distinct pathways modulating intracellular cholesterol trafficking.
L, Liscum, N J, Munn
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Reverse cholesterol transport fluxes
Current Opinion in Lipidology, 2014Reverse cholesterol transport (RCT) is considered a significant component of the atheroprotective effects of HDL. Methods for quantifying flux through the RCT pathway have not been available until recently. There is a need to improve our understanding of HDL function, including the role of RCT in general and individual steps of RCT in particular, on ...
Marc, Hellerstein, Scott, Turner
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1986
Publisher Summary This chapter focuses on the process of reverse cholesterol transport. As peripheral cells do not degrade cholesterol, the only mechanism for removal is by efflux of intact free (unesterified) cholesterol molecules. Such molecules enter the “reverse cholesterol transport” pathway whereby they are delivered to the liver, converted to ...
G H, Rothblat +2 more
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Publisher Summary This chapter focuses on the process of reverse cholesterol transport. As peripheral cells do not degrade cholesterol, the only mechanism for removal is by efflux of intact free (unesterified) cholesterol molecules. Such molecules enter the “reverse cholesterol transport” pathway whereby they are delivered to the liver, converted to ...
G H, Rothblat +2 more
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Cholesterol Efflux and Reverse Cholesterol Transport: Experimental Approaches
Current Medicinal Chemistry, 2016Cholesterol efflux as a key event in reverse cholesterol transport (RCT) is considered now as both diagnostic tool and a promising target for the treatment of atherosclerosis. Radioactive in vitro cholesterol efflux assay (CEA) is the gold standard for determination of efflux at cellular level. Fluorescent tracers and stable isotope-labeled cholesterol
Dmitry Y, Litvinov +3 more
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ABC transporters and cholesterol metabolism
Frontiers in Bioscience, 2001ATP-binding cassette (ABC) proteins form a group of highly conserved cellular transmembrane transporters. Studies over the past year have implicated ABC transporters in cellular lipid trafficking processes. This notion has recently been confirmed and extended by the finding that the ABC transporter ABCA1 is a key regulator of high-density lipoprotein ...
G, Schmitz, W E, Kaminski
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HDL cholesterol transport during inflammation
Current Opinion in Lipidology, 2007The aim of this article is to review recent advances made towards understanding how inflammation and acute phase proteins, particularly serum amyloid A and group IIa secretory phospholipase A2, may alter reverse cholesterol transport by HDL during inflammation and the acute phase response.Findings suggest that the decreased apoA-I content and markedly ...
Deneys R, van der Westhuyzen +2 more
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Acceleration of reverse cholesterol transport
Current Opinion in Cardiology, 2000A low level of high-density lipoprotein (HDL) cholesterol is an important risk factor for coronary heart disease. Levels of HDL cholesterol and composition of HDL subclasses in plasma are regulated by many factors, including apolipoproteins, lipolytic enzymes, lipid transfer proteins, receptors, and cellular transporters.
A, von Eckardstein +2 more
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Lecithin: Cholesterol Acyltransferase and Intravascular Cholesterol Transport
1982Publisher Summary This chapter discusses the role of lecithin cholesterol acyltransferase (LCATase) and intravascular cholesterol transport in human plasma. In contrast to unesterified cholesterol, which transfers and equilibrates rapidly among lipoproteins and between lipoproteins and cells, plasma cholesteryl esters are taken up by cells mostly via
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1994
The plasma concentrations of the different plasma lipoproteins have been associated with coronary artery disease since the pioneering ultracentrifugal studies of John Gofman and his colleagues in Berkeley in the late 1940s1’2. The direct correlation of the concentration of the cholesteryl ester-rich low density lipoproteins (LDL)* with cholesterol ...
Jeffrey M. Hoeg, Alan T. Remaley
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The plasma concentrations of the different plasma lipoproteins have been associated with coronary artery disease since the pioneering ultracentrifugal studies of John Gofman and his colleagues in Berkeley in the late 1940s1’2. The direct correlation of the concentration of the cholesteryl ester-rich low density lipoproteins (LDL)* with cholesterol ...
Jeffrey M. Hoeg, Alan T. Remaley
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The role of intracellular cholesterol transport in cholesterol homeostasis
Trends in Cell Biology, 1996How cholesterol is transported among the membranes of the cell is obscure. Similarly, the mechanisms governing the abundance of cell cholesterol are not entirely understood. It may be, however, that a link exists between the intracellular transport of cholesterol and its homeostasis.
Y, Lange, T L, Steck
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