Results 111 to 120 of about 1,698,727 (261)

Elevation of plasma phospholipid transfer protein increases the risk of atherosclerosis despite lower apolipoprotein B-containing lipoproteins. [PDF]

, 2004
Plasma phospholipid transfer protein (PLTP) transfers phospholipids between lipoproteins and mediates HDL conversion. PLTP-overexpressing mice have increased atherosclerosis.
Arai, Arie van Tol, Barter, Barter, Bruce, De Geest, Delsing, Ehnholm, Farah Sadeghi-Niaraki, Fielding, Forte, Föger, Herrera, Huuskonen, Jauhiainen, Jessica Lie, Jiang, Jiang, Jiang, Kawano, Leo Scheek, Libby, Lie, Lie, Mackness, Marotti, Mason, Okamoto, Plump, Qin, Quarck, Redgrave, Rien van Haperen, Rini de Crom, Rodrigo, Rye, Shih, Speijer, Tall, Teus van Gent, Tselepis, Tu, Tward, Van Haperen, Van Tol, Van Tol, Watson, Wolfbauer   +47 more
core   +3 more sources

Cholesteryl Ester Transfer Protein Inhibitors

Journal of Cardiovascular Pharmacology and Therapeutics, 2016
The cholesteryl ester transfer protein (CETP) is a plasma protein that plays an important role in the transfer of lipids between plasma lipoproteins. The CETP inhibitors have been widely studied as a pharmacologic therapy to target plasma cholesterol in order to reduce the risk of atherosclerotic cardiovascular disease .
Julian Hardy, McLain, Andrew Jacob, Alsterda, Rohit R, Arora   +2 more
openaire   +2 more sources

Comparative Transcriptomic Analysis of Human Macrophages During Mycobacterium avium Versus Mycobacterium tuberculosis Infection

Molecular Microbiology, EarlyView.
Human macrophage transcriptomic responses to Mycobacterium avium (Mav), a major cause of nontuberculous lung disease, were compared to Mycobacterium tuberculosis (Mtb). Both infections activated overlapping immune pathways, including cytokine signaling and GPCRs involved in lipid metabolism, while phospholipases were more strongly regulated by Mav and ...
Gül Kilinç, Robin H. G. A. van den Biggelaar, Tom H. M. Ottenhoff, Leon H. Mei, Anno Saris   +4 more
wiley   +1 more source

Regulation of neutral cholesterol esterase activity by phospholipids containing negative charges in substrate liposome

Journal of Lipid Research, 1995
The effect of phospholipids on cholesteryl ester hydrolysis by neutral cholesterol esterase in alveolar macrophages was studied. Among the phospholipids used as emulsifiers, those with a negative charge, such as phosphatidylserine, phosphatidic acid ...
I Ishii, R Onozaki, E Takahashi, S Takahashi, N Fujio, T Harada, N Morisaki, K Shirai, Y Saito, S Hirose   +9 more
doaj   +1 more source

Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport[S]

Journal of Lipid Research, 2010
The mechanism by which cholesteryl ester transfer protein (CETP) activity affects HDL metabolism was investigated using agents that selectively target CETP (dalcetrapib, torcetrapib, anacetrapib). In contrast with torcetrapib and anacetrapib, dalcetrapib
E. Niesor, C. Magg, N. Ogawa, H. Okamoto, E. von der Mark, H. Matile, G. Schmid, R. G. Clerc, Evelyne Chaput, Denise Blum-Kaelin, W. Huber, R. Thoma, P. Pflieger, M. Kakutani, D. Takahashi, Gregor Dernick, C. Maugeais   +16 more
semanticscholar   +1 more source

Unravelling the biochemical aspects of the interaction between ticks and Leishmania using a tick cell line

Medical and Veterinary Entomology, EarlyView.
Leishmania infantum propagated in IDE8 tick cell line in vitro. L. infantum reduces tick cell viability and induces reactive oxygen species production. Lipidic profile of IDE8 tick cell line is altered during Leishmania infection. Abstract Leishmaniasis comprises a group of vector‐borne neglected tropical diseases caused by species of the obligatory ...
Beatriz Filgueiras Silvestre, Karoline dos Anjos Lima, Fernanda de Paula Pepino, Daniela Cosentino‐Gomes, Adivaldo Fonseca, Lesley Bell‐Sakyi, Georgia Correa Atella, Lucia H. Pinto‐da‐Silva   +7 more
wiley   +1 more source

Cholesterol efflux from cells enriched with cholesteryl esters by incubation with hypercholesterolemic monkey low density lipoprotein

Journal of Lipid Research, 1983
The mass efflux of free and esterified cholesterol was studied in skin fibroblasts loaded with cholesterol by incubation with low density lipoproteins (LDL) isolated from normal or hypercholesterolemic cynomolgus monkeys.
R W St Clair, M A Leight
doaj   +1 more source

Cellular cholesteryl ester clearance. Relationship to the physical state of cholesteryl ester inclusions.

Journal of Biological Chemistry, 1983
The hypothesis that clearance of cellular cholesteryl ester deposits may be a function of the physical state of the stored lipid has been investigated. Cultured rat hepatoma cells were induced to store cholesteryl ester in either anisotropic inclusions by exposure to free cholesterol-rich phospholipid dispersions or isotropic inclusions by exposure to ...
J M, Glick, S J, Adelman, M C, Phillips, G H, Rothblat   +3 more
openaire   +2 more sources

Biochemical characterization of cholesteryl ester transfer protein inhibitors

Journal of Lipid Research, 2010
Cholesteryl ester transfer protein (CETP) has been identified as a novel target for increasing HDL cholesterol levels. In this report, we describe the biochemical characterization of anacetrapib, a potent inhibitor of CETP.
M. Ranalletta, Kathleen K. Bierilo, Ying Chen, D. Milot, Qing Chen, E. Tung, C. Houde, Nadine H. Elowe, M. Garcia-Calvo, Gene Porter, S. Eveland, Betsy Frantz-Wattley, M. Kavana, G. Addona, P. Sinclair, C. Sparrow, E. O’neill, K. Koblan, A. Sitlani, B. Hubbard, T. Fisher   +20 more
semanticscholar   +1 more source

Plant Lipid Droplets and Derived Lipidic Nano‐Assemblies: Structure, Biogenesis and Pharmaceutical Applications

Plant Biotechnology Journal, EarlyView.
ABSTRACT Lipid droplets (LDs) serve as the primary storage site for neutral lipids in plant cells, with growing evidence supporting many additional biological roles, such as in lipid homeostasis, signalling, trafficking, inflammatory responses and inter‐organelle communication.
Abdulsamie Hanano, Amal Yousfan, Denis J. Murphy   +2 more
wiley   +1 more source