Results 91 to 100 of about 7,033,015 (228)

Cholesteryl ester transfer protein expression attenuates atherosclerosis in ovariectomized mice

Journal of Lipid Research, 2003
Reduced estrogen levels result in loss of protection from coronary heart disease in postmenopausal women. Enhanced and diminished atherosclerosis have been associated with plasma levels of cholesteryl ester transfer protein (CETP); however, little is ...
Patrícia M. Cazita, Jairo A. Berti, Carolina Aoki, Magnus Gidlund, Lila M. Harada, Valéria S. Nunes, Eder C.R. Quintão, Helena C.F. Oliveira   +7 more
doaj   +1 more source

GSTM4 Suppresses Prostate Cancer Progression by Targeting TRIM27‐mediated ACLY Ubiquitination and Lipid Metabolism

Advanced Science, Volume 13, Issue 62, 9 November 2026.
GSTM4 enhances the interaction between ACLY and the E3 ubiquitin ligase TRIM27, thereby increasing K48‐linked ubiquitination at the K554 site of ACLY and promoting its degradation. Consequently, GSTM4 regulates lipid synthesis, as well as the proliferation and metastasis of PCa cells, by modulating ACLY stability.
Kang‐Ping Xiong, Fei Liu, Wang Wang, Gang Wang, Kai‐Yu Qian, Sheng Tu, Si‐Ming Chen, Hui‐Min Xu, Shan‐Shan Zhang, Yong Li, Xing‐Huan Wang, Hong Weng   +11 more
wiley   +1 more source

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, Volume 123, Issue 11, Page 3079-3105, November 2026.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

Fenofibrate increases HDL-cholesterol by reducing cholesteryl ester transfer protein expression

Journal of Lipid Research, 2007
In addition to efficiently decreasing VLDL-triglycerides (TGs), fenofibrate increases HDL-cholesterol levels in humans. We investigated whether the fenofibrate-induced increase in HDL-cholesterol is dependent on the expression of the cholesteryl ester ...
Caroline C. van der Hoogt, Willeke de Haan, Marit Westerterp, Menno Hoekstra, Geesje M. Dallinga-Thie, Johannes A. Romijn, Hans M.G. Princen, J. Wouter Jukema, Louis M. Havekes, Patrick C.N. Rensen   +9 more
doaj   +1 more source

How anacetrapib inhibits the activity of the cholesteryl ester transfer protein? Perspective through atomistic simulations. [PDF]

, 2014
Cholesteryl ester transfer protein (CETP) mediates the reciprocal transfer of neutral lipids (cholesteryl esters, triglycerides) and phospholipids between different lipoprotein fractions in human blood plasma. A novel molecular agent known as anacetrapib
Aijanen, T., Sami Rissanen, Tomasz Rog, Tarja Äijänen, Artturi Koivuniemi, Matti Javanainen (621722), Tarja Äijänen (663832), Matti Javanainen, Rog, T., Koivuniemi, A., Javanainen, M., Artturi Koivuniemi (188184), Rissanen, S., Vattulainen, I., Ilpo Vattulainen, Tomasz Rog (1568779), Ilpo Vattulainen (188193), Sami Rissanen (663833)   +17 more
core   +1 more source

Decreased PLTP mass but elevated PLTP activity linked to insulin resistance in HTG

Journal of Lipid Research, 2003
Hypertriglyceridemia (HTG) is associated with insulin resistance, increased cholesteryl ester transfer (CET), and low HDL cholesterol. Phospholipid transfer protein (PLTP) may be involved in these relationships.
Iris J.A.M. Jonkers, Augustinus H.M. Smelt, Hiroaki Hattori, Leo M. Scheek, Teus van Gent, Frits H.A.F. de Man, Arnoud van der Laarse, Arie van Tol   +7 more
doaj   +1 more source

Posttranslational Modification Cross‐Talk in Vascular Cells: Molecular Mechanisms and Therapeutic Implications for Atherosclerosis

Cell Biochemistry and Function, Volume 44, Issue 11, November 2026.
ABSTRACT Atherosclerosis is driven by coordinated changes in endothelial cells (ECs), macrophages, and vascular smooth muscle cells (VSMCs). Post‐translational modifications (PTMs), phosphorylation, acetylation, ubiquitination, SUMOylation, O‐GlcNAcylation, palmitoylation, ISGylation, and ADP‐ribosylation, integrate metabolic, inflammatory, and ...
Weiwei Jiang, Haiping Du
wiley   +1 more source

Oxidation of LDL enhances the cholesteryl ester transfer protein (CETP)-mediated cholesteryl ester transfer rate to HDL, bringing on a diminished net transfer of cholesteryl ester from HDL to oxidized LDL

, 2015
Cholesteryl ester transfer protein (CETP) plays a controversial role in atherogenesis by contributing to the net transfer of high density lipoprotein (HDL) cholesteryl ester (CE) to the liver via apolipoprotein-B-containing lipoproteins (apoB-LP).
Oliveira, HCF, Castilho, LN, de Oliveira, AC, Cazita, PM, Sesso, A, Quintao, ECR   +5 more
core   +1 more source

The effects of curcumin and a modified curcumin formulation on serum Cholesteryl Ester Transfer Protein concentrations in patients with metabolic syndrome: A randomized, placebo-controlled clinical trial [PDF]

, 2018
Objective: Cholesteryl Ester Transfer Protein (CETP) mediates the transfer of cholesteryl ester from HDL-C to LDL-C and VLDL-C. The aim of the present trial was to evaluate the effect of curcumin and its modified formulation on serum CETP concentrations ...
Alireza Pasdar, Maliheh Moammeri, Behdokht Fathi Dizaji, Maryam Saberi Karimian, Hamideh Safarian Bana, Gordon A. A. Ferns, Seyed Mohammad Reza Parizadeh, Asma Afshari, Majid Ghayour Mobarhan, Ali Javandoost, Amirhosein Sahebkar, Shima Tavalaei   +11 more
core   +2 more sources

Conversion of lipid transfer inhibitor protein (apolipoprotein F) to its active form depends on LDL composition

Journal of Lipid Research, 2011
Lipid transfer inhibitor protein (LTIP) exists in both active and inactive forms. Incubation (37°C) of plasma causes LTIP to transfer from a 470 kDa inactive complex to LDL where it is active. Here, we investigate the mechanisms underlying this movement.
Richard E. Morton, Diane J. Greene
doaj   +1 more source