Results 81 to 90 of about 7,033,015 (228)

Dyslipidaemia, Chronic Kidney Disease and Diabetes Mellitus: A Triple Threat to Cardiovascular Health

Diabetes, Obesity and Metabolism, Volume 28, Issue 12, Page 10961-10976, December 2026.
ABSTRACT Diabetes mellitus (DM) and chronic kidney disease (CKD) frequently coexist and together create a ‘triple threat’ with dyslipidaemia, enhancing the risk for cardiovascular morbidity and mortality. Diabetic kidney disease (DKD) leads to altered lipid metabolism through insulin resistance, inflammation and oxidative stress resulting in an ...
Ann S. Forrest, Priyanka Majety, Stéphanie B. Mayer, Om P. Ganda   +3 more
wiley   +1 more source

Apolipoprotein composition of HDL in cholesteryl ester transfer protein deficiency

Journal of Lipid Research, 2004
Our purpose was to compare HDL subpopulations, as determined by nondenaturing two-dimensional gel electrophoresis followed by immunoblotting for apolipoprotein A-I (apoA-I), apoA-II, apoA-IV, apoCs, and apoE in heterozygous, compound heterozygous, and ...
Bela F. Asztalos, Katalin V. Horvath, Kouji Kajinami, Chorthip Nartsupha, Caitlin E. Cox, Marcelo Batista, Ernst J. Schaefer, Akihiro Inazu, Hiroshi Mabuchi   +8 more
doaj   +1 more source

TMEM55B Maintains Lysosomal Homeostasis and Promotes ER–Lysosome Calcium Signaling

Traffic, Volume 27, Issue 4, December 2026.
Hypothetical model: The lysosomal protein TMEM55B interacts with an ER protein complex containing Protrudin and PDZD8 at ER–lysosome membrane contact sites, and also acts to stabilize v‐ATPase in lysosomes. Through these interactions, TMEM55B contributes to the maintenance of luminal homeostasis, including lysosomal acidification and regulates ER ...
Nagi Mukae, Honoka Maki, Michiko Shirane
wiley   +1 more source

Cholesteryl ester transfer-protein modulator and inhibitors and their potential for the treatment of cardiovascular diseases

Vascular Health and Risk Management, 2012
Hisashi ShinkaiCentral Pharmaceutical Research Institute, JT Inc, Osaka, JapanAbstract: Elevated low-density lipoprotein (LDL) cholesterol and lowered high-density lipoprotein (HDL) cholesterol are important risk factors for cardiovascular disease ...
Shinkai H
doaj  

Rapid purification of human plasma lipid transfer proteins.

Journal of Lipid Research, 1990
Lipid transfer protein (LTP) was isolated from human plasma after lipoproteins were removed by precipitation with dextran sulfate. Three sequential chromatogrpahic procedures were used: butyl-Toyopearl 650, CM-Toyopearl 650, and Toyopearl HW-55.
T Ohnishi, S Yokoyama, A Yamamoto
doaj   +1 more source

Fluvastatin Plus Dipyridamole Suppresses Canine Hemangiosarcoma Growth in Patient‐Derived Xenograft Models Through Lactate Dehydrogenase‐Associated Cholesterol/Lipid Metabolism

Veterinary and Comparative Oncology, Volume 24, Issue 4, Page 769-780, December 2026.
ABSTRACT Tumour cells commonly exhibit aerobic glycolysis and produce lactate despite oxygen availability. Lactate dehydrogenase (LDH) catalyses pyruvate‐lactate interconversion and regulates intracellular lactate levels. Endothelial cells also depend on glycolysis for ATP production, which prompted us to investigate LDH in canine hemangiosarcoma (HSA),
Tamami Suzuki, Suzune Tanaka, Keika Kishimoto, Takuma Goto, Jumpei Yamazaki, Takashi Kimura, Keisuke Aoshima   +6 more
wiley   +1 more source

A novel explanation for the reduced LDL cholesterol in severe hypertriglyceridemia.

Journal of Lipid Research, 1989
When [3H]cholesteryl ester-labeled low density (LDL) and intermediate density lipoproteins (IDL) from a normotriglyceridemic, hypercholesterolemic rabbit were injected into severely hypertriglyceridemic, hypercholesterolemic rabbits, 60% of the label ...
A Minnich, B G Nordestgaard, D B Zilversmit   +2 more
doaj   +1 more source

Metal Compound‐Based Non‐Enzymatic Electrochemical Cholesterol Sensors: Emerging Materials and Mechanistic Insights

Advanced Materials Interfaces, Volume 13, Issue 21, 6 November 2026.
This review discusses recent progress in metal complex‐based, non‐enzymatic electrochemical sensors for cholesterol detection. We examine metal oxides, metal sulfides, and hybrid nanomaterials, highlighting their catalytic mechanisms and material design strategies.
Longfei (Jack) Yin, Chao‐Tsen (Rora) Chen, Jacopo Giaretta, Thanh‐Qua Nguyen, Hoang‐Phuong Phan, Fariba Dehghani, Syamak Farajikhah   +6 more
wiley   +1 more source

One common polymorphism of cholesteryl ester transfer protein gene in Iranian subjects with and without primary hypertriglyceridemia [PDF]

, 2007
Primary hypertriglyceridemia is considered to be a major risk factor for pancreatitis, atherosclerosis and coronary heart disease. Cholesteryl ester transfer protein gene polymorphisms known to be associated with changes in lipid levels.
Firoozrai, M., Zonouz, A.E., Ghasabeh, T.H., Zavarehee, A., Radmehr, H., Paoli, M.   +5 more
core  

Effect of a Common Mutation (D442G) of the Cholesteryl Ester Transfer Protein Gene on Lipids and Lipproteins in Children

, 2011
Cholesteryl ester transfer protein (CETP) is though to regulate plasma HDL. Patients with CETP deficiency caused by mutation of the CETP gene (D442G; a missense mutation (Asp442- Gly) have been reported to show high plasma HDL levels. 
Keisuke Katsuren, Shigeru Fukuyama, Takao Ohta, Rina Arashiro, Kyu Kyu Maung   +4 more
core   +1 more source