Results 61 to 70 of about 12,113 (146)

Apolipoprotein composition of HDL in cholesteryl ester transfer protein deficiency

Journal of Lipid Research, 2004
Our purpose was to compare HDL subpopulations, as determined by nondenaturing two-dimensional gel electrophoresis followed by immunoblotting for apolipoprotein A-I (apoA-I), apoA-II, apoA-IV, apoCs, and apoE in heterozygous, compound heterozygous, and ...
Bela F. Asztalos, Katalin V. Horvath, Kouji Kajinami, Chorthip Nartsupha, Caitlin E. Cox, Marcelo Batista, Ernst J. Schaefer, Akihiro Inazu, Hiroshi Mabuchi   +8 more
doaj   +1 more source

Beyond PEG: Emerging Polymer Lipid Alternatives for Lipid Nanoparticle (LNP) Formulations

Advanced Science, Volume 13, Issue 50, 7 September 2026.
This review discusses recent advances in PEG‐alternative LNP designs, including non‐PEG polymers, zwitterionic lipids, and polypeptides. It evaluates how surface‐engineering chemistry influences LNP formation and biological behavior, and highlights current limitations and opportunities of PEG‐alternative LNPs.
Zihnil A. I. Mazrad, Yi Ju, Stephen J. Kent, Colin W. Pouton, Kristian Kempe   +4 more
wiley   +1 more source

A novel explanation for the reduced LDL cholesterol in severe hypertriglyceridemia.

Journal of Lipid Research, 1989
When [3H]cholesteryl ester-labeled low density (LDL) and intermediate density lipoproteins (IDL) from a normotriglyceridemic, hypercholesterolemic rabbit were injected into severely hypertriglyceridemic, hypercholesterolemic rabbits, 60% of the label ...
A Minnich, B G Nordestgaard, D B Zilversmit   +2 more
doaj   +1 more source

Reconsidering the impact of saturated fat intake on metabolic health: A critical review of evidence and controversies

Food Biomacromolecules, Volume 3, Issue 3, Page 584-603, September 2026.
Abstract Saturated fats (SFAs) play a complex role in health; therefore, their intake has been a topic of debate in the field of nutrition science. Therefore, this article emphasizes the importance of a balanced diet rather than SFA, considering genetic and metabolic differences, and advocates for the reconsideration of dietary guidelines based on the ...
Akash Kumar, Dipak S. Thorat, Sangeeta Yadav, Pooja Yadav, Jhilam Pramanik, Yogesh V. Ushir, Sudarshan Singh, Bhupendra G. Prajapati   +7 more
wiley   +1 more source

Cholesteryl ester transfer protein inhibitors for dyslipidemia: focus on dalcetrapib

Drug Design, Development and Therapy, 2012
Alyse S Goldberg, Robert A HegeleDepartment of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ontario, CanadaAbstract: Among the noteworthy recent stories in the management and prevention of atherosclerotic ...
Goldberg AS, Hegele RA
doaj  

Cholesteryl ester transfer protein expression attenuates atherosclerosis in ovariectomized mice

Journal of Lipid Research, 2003
Reduced estrogen levels result in loss of protection from coronary heart disease in postmenopausal women. Enhanced and diminished atherosclerosis have been associated with plasma levels of cholesteryl ester transfer protein (CETP); however, little is ...
Patrícia M. Cazita, Jairo A. Berti, Carolina Aoki, Magnus Gidlund, Lila M. Harada, Valéria S. Nunes, Eder C.R. Quintão, Helena C.F. Oliveira   +7 more
doaj   +1 more source

Type 2 Diabetes Mellitus Modifies the Prognostic Value of LDL Particle Size in Statin‐treated Patients With Coronary Artery Disease: A Large‐scale Cohort Study

MedComm, Volume 7, Issue 9, September 2026.
The LDL‐C/ApoB ratio, a marker of LDL size, showed significant prognostic value in statin‐treated CAD patients depending on diabetes status. A higher ratio was linked to lower cardiovascular risk only in patients with type 2 diabetes, suggesting it may be a superior biomarker for risk stratification beyond conventional lipids in this high‐risk group ...
Xiaohui Bian, Jining He, Chenxi Song, Rui Zhang, Sheng Yuan, Guofeng Gao, Kefei Dou   +6 more
wiley   +1 more source

Fenofibrate increases HDL-cholesterol by reducing cholesteryl ester transfer protein expression

Journal of Lipid Research, 2007
In addition to efficiently decreasing VLDL-triglycerides (TGs), fenofibrate increases HDL-cholesterol levels in humans. We investigated whether the fenofibrate-induced increase in HDL-cholesterol is dependent on the expression of the cholesteryl ester ...
Caroline C. van der Hoogt, Willeke de Haan, Marit Westerterp, Menno Hoekstra, Geesje M. Dallinga-Thie, Johannes A. Romijn, Hans M.G. Princen, J. Wouter Jukema, Louis M. Havekes, Patrick C.N. Rensen   +9 more
doaj   +1 more source

Urotensin II Receptor Deletion Mitigates Kidney Injury and Renal Lipid Remodeling in Mice Fed a Long‐Term High‐Fat Diet

FASEB BioAdvances, Volume 8, Issue 9, September 2026.
Urotensin II receptor deletion mitigates high‐fat diet‐induced kidney injury and renal lipid remodeling. Male wild‐type (WT) and urotensin II receptor–knockout (UT KO) mice were fed a high‐fat diet (HFD; 60% kcal from fat) for 33 weeks. In cultured mouse podocytes, urotensin II (UII)–UT signaling enhanced transient receptor potential canonical 6 (TRPC6)
Praghalathan Kanthakumar, Adebowale Adebiyi   +1 more
wiley   +1 more source

Decreased PLTP mass but elevated PLTP activity linked to insulin resistance in HTG

Journal of Lipid Research, 2003
Hypertriglyceridemia (HTG) is associated with insulin resistance, increased cholesteryl ester transfer (CET), and low HDL cholesterol. Phospholipid transfer protein (PLTP) may be involved in these relationships.
Iris J.A.M. Jonkers, Augustinus H.M. Smelt, Hiroaki Hattori, Leo M. Scheek, Teus van Gent, Frits H.A.F. de Man, Arnoud van der Laarse, Arie van Tol   +7 more
doaj   +1 more source