Results 71 to 80 of about 7,033,015 (228)

Interpretable multimodal network analysis of lipid‐lowering therapies

British Journal of Pharmacology, EarlyView.
Background and Purpose Multimodal integration of clinical and omics data could clarify the hepatic mechanisms of lipid‐lowering therapies, but interpretable methods for heterogeneous data remain limited. The objective was to apply interpretable multimodal networks (IMNs), a topology‐aware framework that condenses heterogeneous omics and clinical data ...
Daniele Dall'Olio, Matteo Pedrelli, Claudia Sala, Francesca Grassi, Ruisheng Wang, Osman Ahmed, Carsten O. Daub, Daniel Remondini, Gastone Castellani, Davide Gentilini, Chiara Pirazzini, Paolo Garagnani, Enrico Petrillo, Matteo Bersanelli, Elliott M. Antman, Joseph Loscalzo, Paolo Parini   +16 more
wiley   +1 more source

Assessing the mechanisms of cholesteryl ester transfer protein inhibitors [PDF]

, 2017
Cholesteryl ester transfer protein (CETP) inhibitors are a new class of therapeutics for dyslipidemia that simultaneously improve two major cardiovascular disease (CVD) risk factors: elevated low-density lipoprotein (LDL) cholesterol and decreased high ...
M. Art Charles, Douglas G. Johns, Krauss, Ronald M, Ronald M. Krauss, Peng, Bo, Lei, Dongsheng, Peng, B, Lei Zhang, Ren, Gang, Bo Peng, Lei, D, Johns, DG, Charles, M Art, Mickey Yang, Yang, M, Ren, G, Kerry-Anne Rye, Charles, MA, Krauss, RM, Johns, Douglas G, Meng Zhang, Zhang, Lei, Gang Ren, Rye, Kerry-Anne, Rye, KA, Yang, Mickey, Dongsheng Lei, Zhang, M, Zhang, L, Zhang, Meng   +29 more
core   +1 more source

Novel ABCA1 mutations in Tangier disease associated with early‐onset type 2 diabetes: A case report

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Tangier disease (TD) is a rare disorder caused by mutations in the ATP‐binding cassette transporter A1 (ABCA1) gene with autosomal recessive inheritance and is characterized by extremely low high‐density lipoprotein cholesterol (HDL‐C) and premature atherosclerosis.
Makoto Wada, Naoko Saito‐Sato, Masaki Tanaka, Junko Nomoto, Aki Watanabe, Masayuki Kuroda, Yoshiro Maezawa, Tetsuta Sato, Yusuke Yagyu, Shuji Toriumi, Amika Kajiyama, Takahide Hashimoto, Naoki Ohtake, Masaya Yamaga, Tomohiko Yoshida, Shoji Tsuji, Minoru Takemoto   +16 more
wiley   +1 more source

Leptin–cholesterol crosstalk in pregnancy: Mechanistic implications for placental function and cardiometabolic programming

Experimental Physiology, EarlyView.
Abstract Pregnancy requires the coordinated maternal reorganization of lipid and endocrine pathways to sustain fetal growth and anticipate neonatal nutrition. Leptin, produced by adipose tissue and the placenta, acts as an integrative signal linking maternal energy status with trophoblast function and vascular adaptation, while cholesterol provides ...
Julio Flores, Diego Gumera, Andreina Arias, Cristián A. Amador, María José Yañez   +4 more
wiley   +1 more source

Abnormal high density lipoproteins of abetalipoproteinemia: relevance to normal HDL metabolism

Journal of Lipid Research, 1982
We investigated high density lipoprotein (HDL) subfractions in abetalipoproteinemia (ABL) using rate zonal ultracentrifugation. In ABL, HDL2 is the major subfraction, 65% of total mass compared to less than 10% in normal subjects with similar HDL levels.
R J Deckelbaum, S Eisenberg, Y Oschry, M Cooper, C Blum   +4 more
doaj   +1 more source

An Anatomist's View on the Crosstalk Between the Liver and the Lung

Comprehensive Physiology, Volume 16, Issue 6, December 2026.
The liver and the lung have a similar three‐dimensional and cellular architecture as well as functional communalities. The structural, functional, and pathophysiological interplay between both organs suggests the existence of an interorgan axis, the liver‐lung axis. Created in biorender.com.
Tanja Kloock, Julia Schipke, Christian Mühlfeld   +2 more
wiley   +1 more source

Allelic variation in the gene encoding the cholesteryl ester transfer protein is associated with variation in the plasma concentrations of cholesteryl ester transfer protein.

Journal of Lipid Research, 1996
The cholesteryl ester transfer protein (CETP) mediates the transfer of cholesteryl esters from high density lipoproteins (HDL) to triglyceride-rich lipoproteins. Mutations that abolish CETP function are associated with very high levels of HDL cholesterol,
R McPherson, S M Grundy, R Guerra, J C Cohen   +3 more
doaj   +1 more source

From Association to Mechanism: Regulatory Annotation and Pathway Mapping of Genes Surrounding Breast Cancer Risk Variants

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Inherited factors account for a large share of breast cancer susceptibility, yet the biological consequences of most risk variants are still poorly understood. To address this gap, we studied 175 breast cancer risk variants confirmed by genome‐wide association studies and gathered the genes that lie near them.
Sultana Jannat, Trina Mitra, Nafisa Nawar Fariha, Tasmia Tabassum, Kulsuma Bahar Bethi, Synchita Majumder Kaya, Md. Arif Hossen, Md. Saad Hossain, Jobaier Ibne Deen, Mohammed Emon, Laila Khaleda, Md. Hridoy Ahmed   +11 more
wiley   +1 more source

Cholesteryl ester transfer protein: at the heart of the action of lipid-modulating therapy with statins, fibrates, niacin, and cholesteryl ester transfer protein inhibitors.

, 2010
International audienceSubnormal plasma levels of high-density lipoprotein cholesterol (HDL-C) constitute a major cardiovascular risk factor; raising low HDL-C levels may therefore reduce the residual cardiovascular risk that frequently presents in ...
Kontush, Anatol, Le Goff, Wilfried, Guerin, Maryse, Chapman, M John   +3 more
core   +1 more source

Lecithin:cholesterol acyltransferase and cholesteryl ester transfer activity from the isolated perfused rabbit liver.

Journal of Lipid Research, 1984
Lecithin:cholesterol acyltransferase (LCAT) and cholesteryl ester (CE) transfer activity accumulate linearly in the recirculated medium of the isolated perfused rabbit liver.
L De Parscau, P E Fielding
doaj   +1 more source