Results 51 to 60 of about 7,033,015 (228)

Structural and biophysical insight into cholesteryl ester-transfer protein

, 2011
CETP (cholesteryl ester-transfer protein) is essential for neutral lipid transfer between HDL (high-density lipoprotein) and LDL (low-density lipoprotein) and plays a critical role in the reverse cholesterol transfer pathway.
Justin Hall, Xiayang Qiu
core   +1 more source

Familial cholesteryl ester transfer protein deficiency is associated with triglyceride-rich low density lipoproteins containing cholesteryl esters of probable intracellular origin.

Journal of Lipid Research, 1991
The net transfer of core lipids between lipoproteins is facilitated by cholesteryl ester transfer protein (CETP). We have recently documented CETP deficiency in a family with hyperalphalipoproteinemia, due to a CETP gene splicing defect.
CL Bisgaier, MV Siebenkas, ML Brown, A Inazu, J Koizumi, H Mabuchi, AR Tall   +6 more
doaj   +1 more source

Cholesteryl Ester Transfer Protein Inhibitors

Journal of Cardiovascular Pharmacology and Therapeutics, 2016
The cholesteryl ester transfer protein (CETP) is a plasma protein that plays an important role in the transfer of lipids between plasma lipoproteins. The CETP inhibitors have been widely studied as a pharmacologic therapy to target plasma cholesterol in order to reduce the risk of atherosclerotic cardiovascular disease .
Julian Hardy, McLain, Andrew Jacob, Alsterda, Rohit R, Arora   +2 more
openaire   +2 more sources

Single‐Cell RNA Sequencing and Spatial Multiomics Unveil Microglia–Mural Interactions Underlying Notoginsenoside R1 Against Ischemic Stroke

iMetaMed, EarlyView.
Integrated scRNA‐seq and spatial multiomics provide single‐cell and spatial insights into the neuroprotective effects of NGR1, a clinically validated bioactive compound from Panax notoginseng. NGR1 was associated with a shift in microglial transcriptional states away from ischemia‐associated pro‐inflammatory Adam8hi microglia and toward the protective ...
Qikun Zhao, Wenbo Guo, Yanrong Zheng, Guoqian Cui, Bingjie Wan, Shuhui Deng, Hudong Bao, Xiao Tu, Shengshuang Chen, Jie Liao, Xiaohui Fan   +10 more
wiley   +1 more source

Cholesteryl Ester Transfer Protein Gene Mutations In Brazilian Hyperalphalipoproteinemia [8]

, 2015
[No abstract available]695455457de Grooth, G.J., Klerkx, A.H., Stroes, E.S., A review of CETP and its relation to atherosclerosis (2004) J Lipid Res, 45, pp. 1967-1974Tall, A., Plasma lipid transfer proteins (1995) Annu Rev Biochem, 64, pp.
Kaplan D.B., Tentor J., Harada L.M., Schreiber R., Pinheiro H.P., Cruz M.L.Y., Oliveira H.C.F., Nakamura R.T., de Faria E.C.   +8 more
core   +1 more source

Impaired plasma cholesteryl ester transfer with accumulation of larger high density lipoproteins in some families of baboons (Papio sp.).

Journal of Lipid Research, 1990
Baboons from some families have a higher concentration of plasma high density lipoproteins (HDL) on a chow diet and accumulate large HDL (HDL1) when challenged with a high cholesterol and high saturated fat (HCHF) diet.
RS Kushwaha, DL Rainwater, MC Williams, GS Getz, HC McGill, Jr   +4 more
doaj   +1 more source

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

KRIBB-BP005m: A new inhibitor of cholesteryl ester transfer protein(CETP) produced from trichothecium roseum F1064

, 1995
KRIBB-BP005m, A novel tetracyclic compound containing a lactone which inhibits cholesteryl ester transfer protein (CETP), was isolated from a culture broth of Trichothecium roseum F1064 and the structure of KRIBB-BP005m was elucidated on the basis of ...
Ji Youn Nam, Tae Sook Jeong, Sung Uk Kim, Young Kook Kim, Kyou Hoon Han, 이승호, Byoung-Mog Kwon, Song Hae Bok, Kwang Hee Son, Soo-Kyung Kim   +9 more
core   +1 more source

Transfer of cholesteryl ester into high density lipoprotein by cholesteryl ester transfer protein: effect of HDL lipid and apoprotein content.

Journal of Lipid Research, 1989
Recombinant high density lipoprotein (rHDL) particles were prepared by cosonication of purified lipids and human apoproteins and incubated with partly purified cholesteryl ester transfer protein (CETP) and low density lipoprotein (LDL) containing [3H ...
D L Sparks, P H Pritchard
doaj   +1 more source

Regulating Lipid Metabolism in Cancer: The Therapeutic Potential of Traditional Chinese Medicine

Phytotherapy Research, EarlyView.
By regulating the reprogramming of lipid metabolism in tumor cells, TCM provides a novel strategy for antitumor therapy with reduced toxicity and enhanced efficacy. ABSTRACT Lipid metabolic reprogramming is a key feature of tumor cells to adapt to the microenvironment and plays an important role in tumor growth, invasion, and metastasis.
Yufeng Gao, Huiming Huang, Xuejiao Wei, Xiaoxue Wang, Wanying Xie, Xinyu Qiu, Fei Wang, Zhuguo Wang, Ruoxin Zhang, Yilin Cai, Changhai Qu, Zhongdong Hu   +11 more
wiley   +1 more source