Results 61 to 70 of about 4,882 (132)

Role of cholesteryl ester transfer protein (CETP) in the HDL conversion process as evidenced by using anti-CETP monoclonal antibodies

Journal of Lipid Research, 1990
The implication of cholesteryl ester transfer protein (CETP) in the high density lipoprotein (HDL) conversion process was studied by incubating HDL3 with a purified CETP preparation for 24 h at 37 degrees C.
L Lagrost, P Gambert, V Dangremont, A Athias, C Lallemant   +4 more
doaj   +1 more source

Generating golden Syrian hamsters with conditional alleles via zygote microinjection of CRISPR/Cas9

Animal Models and Experimental Medicine, Volume 9, Issue 2, Page 308-318, February 2026.
We established the first conditional knockout (cKO) model in the golden Syrian hamster by CRISPR/Cas9‐mediated genome editing. Cas9 protein, two sgRNAs, and a donor plasmid carrying loxP‐flanked exon 2 of the ApoF gene were microinjected into one‐cell embryos. The floxed allele was efficiently generated (up to 27%) and transmitted through the germline.
Wei Chen, Xu Zhang, Rui Fan, Xia Li, Feifei Guan, Gefan Wan, Weining Kong, Xiaolong Qi, Shuo Pan, Sijing Shi, Yuanlong Su, Shan Gao, Wei Huang, Xunde Xian, Jiangning Liu, Yuhui Wang, Yuanwu Ma   +16 more
wiley   +1 more source

Conversion of lipid transfer inhibitor protein (apolipoprotein F) to its active form depends on LDL composition

Journal of Lipid Research, 2011
Lipid transfer inhibitor protein (LTIP) exists in both active and inactive forms. Incubation (37°C) of plasma causes LTIP to transfer from a 470 kDa inactive complex to LDL where it is active. Here, we investigate the mechanisms underlying this movement.
Richard E. Morton, Diane J. Greene
doaj   +1 more source

Anacetrapib: potential for the prevention and treatment of coronary heart disease

Research Reports in Clinical Cardiology, 2013
Dylan L Steen,1 Amit V Khera,2 Christopher P Cannon1 1TIMI Study Group, Cardiovascular Division, 2Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA Abstract: Despite major advances in cardiovascular care in recent decades ...
Steen DL, Khera AV, Cannon CP
doaj  

Comparative acyl specificities for transfer and selective uptake of high density lipoprotein cholesteryl esters

Journal of Lipid Research, 1991
This study compares the specificities of selective uptake and transfer mediated by plasma cholesteryl ester transfer protein (CETP) for various species of cholesteryl esters in high density lipoproteins (HDL). [3H]Cholesterol was esterified with a series
SR Green, RC Pittman
doaj   +1 more source

Inhibition of cholesteryl ester transfer protein by substituted dithiobisnicotinic acid dimethyl ester: involvement of a critical cysteine

Journal of Lipid Research, 2000
SC-71952, a substituted analog of dithiobisnicotinic acid dimethyl ester, was identified as a potent inhibitor of cholesteryl ester transfer protein (CETP).
Heidi Rath Hope, Deborah Heuvelman, Kevin Duffin, Christine Smith, Jeffery Zablocki, Roger Schilling, Shridhar Hegde, Len Lee, Bryan Witherbee, Mark Baganoff, Can Bruce, Alan R. Tall, Elaine Krul, Kevin Glenn, Daniel T. Connolly   +14 more
doaj   +1 more source

Human plasma CETP deficiency: identification of a novel mutation in exon 9 of the CETP gene in a Caucasian subject from North America

Journal of Lipid Research, 1998
Human plasma cholesteryl ester transfer protein (CETP) is a 476-residue hydrophobic glycoprotein that catalyzes the heterotransfer of cholesteryl esters and triacylglycerols among lipoproteins: Mutations in the CETP gene have been identified, mostly in ...
Evelyn M. Teh, Peter J. Dolphin, W. Carl Breckenridge, Meng-Hee Tan   +3 more
doaj   +1 more source

Cholesteryl ester transfer protein and its inhibitors

Journal of Lipid Research, 2018
Most of the cholesterol in plasma is in an esterified form that is generated in potentially cardioprotective HDLs. Cholesteryl ester transfer protein (CETP) mediates bidirectional transfers of cholesteryl esters (CEs) and triglycerides (TGs) between ...
Sudichhya Shrestha, Ben J. Wu, Liam Guiney, Philip J. Barter, Kerry-Anne Rye   +4 more
doaj   +1 more source

Accelerated cholesteryl ester transfer and altered lipoprotein composition in diabetic cynomolgus monkeys.

Journal of Lipid Research, 1995
To determine whether nonhuman primates demonstrate the same alterations in transport of cholesteryl ester (CE) in plasma observed in diabetic humans, cholesteryl ester transfer (CET) was measured in cynomolgus monkeys with chronic spontaneous diabetes ...
J D Bagdade, J D Wagner, L L Rudel, T B Clarkson   +3 more
doaj   +1 more source

Expression and secretion of rabbit plasma cholesteryl ester transfer protein by Pichia pastoris

Journal of Lipid Research, 1996
The rabbit cholesteryl ester transfer protein (CETP) was expressed in the methylotrophic yeast Pichia pastoris by introducing the CETP cDNA under the control of the methanol-inducible alcohol oxidase promoter.
H Kotake, Q Li, T Ohnishi, K W Ko, L B Agellon, S Yokoyama   +5 more
doaj   +1 more source