Results 41 to 50 of about 4,882 (132)

A CYP7A promoter binding factor site and Alu repeat in the distal promoter region are implicated in regulation of human CETP gene expression

Journal of Lipid Research, 2003
The cholesteryl ester transfer protein (CETP) plays a key role in reverse cholesterol transport in mediating the transfer of cholesteryl ester from HDL to atherogenic apolipoprotein B-containing lipoproteins (VLDL, IDL, and LDL). Variation in plasma CETP
Wilfried Le Goff, Maryse Guerin, M.John Chapman, Joëlle Thillet   +3 more
doaj   +1 more source

From prediction to intervention: Paradigm shifts in causal AI for precision medicine and large‐scale cohorts

VIEW, Volume 7, Issue 4, August 2026.
Large‐scale cohorts and multimodal biomedical data have enabled powerful predictive models for clinical risk stratification, but prediction alone cannot guide effective interventions. This review introduces causal artificial intelligence as a design‐first framework that integrates target trial emulation, causal discovery, and robust effect estimation ...
Linlin Cao, Yudian Xu, Yifan Chen, Honghao Huang, Wei Xu, Jun Pu   +5 more
wiley   +1 more source

Association of cholesteryl ester transfer protein with HDL particles reduces its proteolytic inactivation by mast cell chymase

Journal of Lipid Research, 2008
Human atherosclerotic intima contains mast cells that secrete the neutral protease chymase into the intimal fluid, which also contains HDL-modifying proteins, such as cholesteryl ester transfer protein (CETP), in addition to abundant amounts of nascent ...
Miriam Lee-Rueckert, Riikka Vikstedt, Jari Metso, Matti Jauhiainen, Petri T. Kovanen   +4 more
doaj   +1 more source

Variants in the CETP gene affect levels of HDL cholesterol by reducing the amount, and not the specific lipid transfer activity, of secreted CETP.

PLoS ONE, 2023
BackgroundCholesteryl ester transfer protein (CETP) transfers cholesteryl esters in plasma from high density lipoprotein (HDL) to very low density lipoprotein and low density lipoprotein.
Åsa Schawlann Ølnes, Marianne Teigen, Jon K Laerdahl, Trond P Leren, Thea Bismo Strøm, Katrine Bjune   +5 more
doaj   +1 more source

Design, Synthesis, and Biological Evaluation of Benzylamino-Methanone Based Cholesteryl Ester Transfer Protein Inhibitors

Molecules, 2010
Cholesteryl ester transfer protein (CETP) is a glycoprotein involved in transporting lipoprotein particles and neutral lipids between high-density lipoprotein (HDL) and low density lipoproteins (LDL) and therefore its a proper target for treating ...
Ghadeer Albadawi, Areej Melhem, Reema Abu Khalaf, Ghassan Abu Sheikha   +3 more
doaj   +1 more source

Design, Optimization and Mechanistic Insights Into Terpenoid‐Derived Inhibitors of Protein Kinase C Iota

Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
In this study, we identified a synthetic naphthoquinone merosesquiterpene as a potent PKCι inhibitor, emerging as the most strongly inhibited kinase within a panel of 410 human kinases. Structure–activity relationship (SAR) studies using a focused library of terpenoid analogues highlighted the critical role of the naphthoquinone core and the aromatic ...
Rachid Chahboun, Fernando Rodríguez‐Serrano, Ángel Bueno, Nuria Mut‐Salud, Ramón Alvarez‐Manzaneda, Enrique Alvarez‐Manzaneda, Antonio Fernández   +6 more
wiley   +1 more source

Design, Synthesis, and Biological Evaluation of N,N-Disubstituted-4-Arylthiazole-2-Methylamine Derivatives as Cholesteryl Ester Transfer Inhibitors

Molecules, 2017
Cholesteryl ester transfer protein (CETP) has been identified as a potential target for cardiovascular disease (CVD) for its important role in the reverse cholesteryl transfer (RCT) process.
Xinran Wang, Xuehua Lin, Xuanqi Xu, Wei Li, Lijuan Hao, Chunchi Liu, Dongmei Zhao, Maosheng Cheng   +7 more
doaj   +1 more source

High cholesterol absorption efficiency enhances proatherogenic properties of low‐density lipoprotein particles

Journal of Internal Medicine, Volume 299, Issue 6, Page 711-725, June 2026.
Abstract Background and Aims High cholesterol absorption efficiency is determined by genetic variation in small intestinal sterol transporters and affects one‐third of individuals. Their risk for atherosclerotic cardiovascular disease (ASCVD) is increased compared with low cholesterol absorbers, despite similar serum lipid concentrations.
Katariina Öörni, Lauri Äikäs, Maija Ruuth, Feven Tigistu‐Sahle, Reijo Käkelä, Ingmar Wester, Helena Gylling, Piia Simonen   +7 more
wiley   +1 more source

Evidence for electronegativity of plasma high density lipoprotein-3 as one major determinant of human cholesteryl ester transfer protein activity.

Journal of Lipid Research, 1996
Plasma high density lipoprotein-3 (HDL3) subfractions with different composition and electric charge properties were isolated by anion exchange chromatography; their ability to exchange cholesteryl esters with low density lipoproteins (LDL) in the ...
D Masson, A Athias, L Lagrost
doaj   +1 more source

Apolipoprotein A‐I (CSL112) and Cardiovascular Outcomes in Atherosclerotic Cardiovascular Disease: A Scoping Review

Clinical Cardiology, Volume 49, Issue 5, May 2026.
Apolipoprotein A‐I (ApoA‐I), the principal protein of HDL, plays a key role in reverse cholesterol transport, inflammation modulation, and plaque stabilization in atherosclerotic cardiovascular disease. Emerging ApoA‐I–based therapies, including CSL112, enhance cholesterol efflux capacity, though definitive reductions in cardiovascular events remain ...
Awais Habib, Muhammad Saood Moazzam Khan, Ahmad Aneeq, Hafiz Muhammad Talha Tahir, Amin Mehmoodi, Jahanzeb Malik, Abida Perveen   +6 more
wiley   +1 more source