Results 31 to 40 of about 4,882 (132)

Dyslipidaemia, Chronic Kidney Disease and Diabetes Mellitus: A Triple Threat to Cardiovascular Health

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Diabetes mellitus (DM) and chronic kidney disease (CKD) frequently coexist and together create a ‘triple threat’ with dyslipidaemia, enhancing the risk for cardiovascular morbidity and mortality. Diabetic kidney disease (DKD) leads to altered lipid metabolism through insulin resistance, inflammation and oxidative stress resulting in an ...
Ann S. Forrest, Priyanka Majety, Stéphanie B. Mayer, Om P. Ganda   +3 more
wiley   +1 more source

Low level quantification of cholesteryl ester transfer protein in plasma subfractions and cell culture media by monoclonal antibody-based immunoassay.

Journal of Lipid Research, 1995
Sensitive immunoradiometric (IRMA) and ELISA assays for cholesteryl ester transfer protein (CETP) have been developed using two different monoclonal antibodies (MAbs). The MAbs were prepared against human plasma CETP and demonstrated specificity by their
R W Clark, J B Moberly, M J Bamberger
doaj   +1 more source

Type 2 Diabetes Mellitus Modifies the Prognostic Value of LDL Particle Size in Statin‐treated Patients With Coronary Artery Disease: A Large‐scale Cohort Study

MedComm, Volume 7, Issue 9, September 2026.
The LDL‐C/ApoB ratio, a marker of LDL size, showed significant prognostic value in statin‐treated CAD patients depending on diabetes status. A higher ratio was linked to lower cardiovascular risk only in patients with type 2 diabetes, suggesting it may be a superior biomarker for risk stratification beyond conventional lipids in this high‐risk group ...
Xiaohui Bian, Jining He, Chenxi Song, Rui Zhang, Sheng Yuan, Guofeng Gao, Kefei Dou   +6 more
wiley   +1 more source

Cholesteryl ester transfer protein expression is down-regulated in hyperinsulinemic transgenic mice

Journal of Lipid Research, 2003
Cholesteryl ester transfer protein (CETP) mediates cholesteryl ester (CE) and triglyceride redistribution among plasma lipoproteins. In this work, we investigated whether varying levels of insulin regulate the CETP expression in vivo. Insulin deficiency [
J.A. Berti, A.C. Casquero, P.R. Patrício, E.J.B. Bighetti, E.M. Carneiro, A.C. Boschero, H.C.F. Oliveira   +6 more
doaj   +1 more source

Angiopoietin‐like protein 3 complete and partial deficiency markedly accelerates apolipoprotein B48 and B100 metabolism in triglyceride‐rich lipoproteins in humans

Journal of Internal Medicine, Volume 300, Issue 3, Page 312-328, September 2026.
Abstract Background Angiopoietin‐like protein 3 (ANGPTL3) is a key circulating regulator of triglyceride metabolism and a promising pharmacological target. The physiological consequences of profound ANGPTL3 deficiency can be explored in individuals with inherited loss‐of‐function (LOF) variants, who show reduced lifetime risk of atherosclerotic ...
Marcello Arca, Elias Björnson, Laura D'Erasmo, Alessia Di Costanzo, Simone Bini, Ilenia Minicocci, Daniele Tramontano, Stella Covino, Giuseppe Ciarlo, Manuela Lombardi, Sanni Söderlund, Niina Matikainen, Linda Andersson, Martin Adiels, Marja‐Riitta Taskinen, Chris J. Packard, Jan Borén   +16 more
wiley   +1 more source

The surface cholesteryl ester content of donor and acceptor particles regulates CETP: a liposome-based approach to assess the substrate properties of lipoproteins

Journal of Lipid Research, 2003
Cholesteryl ester transfer protein (CETP) activity is regulated, in part, by lipoprotein composition. We previously demonstrated that CETP activity follows saturation kinetics as cholesteryl ester (CE) levels in the phospholipid surface of donor ...
Richard E. Morton, Diane J. Greene
doaj   +1 more source

Exploring the Roles of Tuna‐Associated Acinetobacter sp. YFT067: Implications for Host Health and Metabolism

Animal Research and One Health, Volume 4, Issue 3, Page 278-292, August 2026.
This study firstly isolated a tuna‐derived gut probiotic Acinetobacter seifertii YFT067. Dietary administration of YFT067 played significant roles in promoting growth performance, SCFAs production, lipid absorption, and metabolism of the host, indicating YFT067 as a promising probiotic candidate for enhancing tuna aquaculture productivity through ...
Ying Zou, Hai Huang, Qiongyao Fu, Zhiyuan Lu, Zhiqiang Guo   +4 more
wiley   +1 more source

Expression of CETP and of splice variants induces the same level of ER stress despite secretion efficiency differences

Journal of Lipid Research, 2008
The cholesteryl ester transfer protein (CETP) gene has been associated with a variety of phenotypes, including HDL-cholesterol levels and, more sporadically, with cardiovascular disease, obesity, and extreme longevity. Alterations of CETP activity levels
Maruja E. Lira, A. Katrina Loomis, Sara A. Paciga, David B. Lloyd, John F. Thompson   +4 more
doaj   +1 more source

Reduced cholesteryl ester transfer in plasma of patients with lipoprotein lipase deficiency.

Journal of Lipid Research, 1996
The net mass transfer of cholesteryl ester (CE) from high density lipoprotein (HDL) to the apolipoprotein (apo) B-containing lipoproteins, very low density lipoprotein (VLDL) and low density lipoprotein (LDL) in plasma (cholesteryl ester transfer (CET ...
J D Bagdade, M C Ritter, H Lithell, D Bassett, F Mailly, P Talmud, M R Hayden   +6 more
doaj   +1 more source

Reconceptualizing Dyslipidemia: Diversity of Lipid Imbalances and Their Clinical Implications; A Narrative Review

Health Science Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background and Aims The traditional definition of dyslipidemia focuses on isolated lipid changes (LDL‐C, HDL‐C, triglycerides) and may not fully capture the biological complexity or clinical variability of lipid imbalances. Recent evidence challenges this narrow view, suggesting that dyslipidemia involves broader disruptions in lipid ...
Ali Mansoursamaei, Amirhossein Yadegar, Fatemeh Mohammadi, Seyed Arsalan Seyedi, Soghra Rabizadeh, Sahar Karimpour Reyhan, Alireza Esteghamati, Manouchehr Nakhjavani   +7 more
wiley   +1 more source