Results 51 to 60 of about 4,882 (132)

Impact of CYP2C19 Genotype Variants on PCSK9 Inhibitor Efficacy in Lipid‐Lowering Among Patients With Symptomatic Intracranial Atherosclerotic Stenosis

Lipids, Volume 61, Issue 3, Page 319-329, May 2026.
ABSTRACT Ischemic stroke is frequently associated with symptomatic intracranial atherosclerotic stenosis (sICAS), is a leading cause of global disability and mortality. Current guidelines recommend dual antiplatelet and intensive statin therapies. Proprotein convertase subtilisin 9/kexin type 9 (PCSK9) inhibitors have emerged as a potent lipid‐lowering
Chao Zhao, Nuan Wang, Di Shi, Hao Zhou, Dan Chen, Guofang Chen   +5 more
wiley   +1 more source

In Situ Lipoprotein‐seeking Dye for in Vivo Real‐Time Imaging of Lipid Dysregulation Diseases

Advanced Science, Volume 13, Issue 19, 2 April 2026.
This study develops lipoprotein‐seeking NIR‐II dyes that specifically bind circulating lipoproteins. These dyes form ultra‐stable complexes with endogenous lipoprotein, enabling real‐time, high‐contrast imaging of fatty liver and atherosclerotic plaques. Tunable binding kinetics allow customized imaging windows.
Yijing Du, Zetao Dang, Baofeng Xu, Jiajun Xu, Dan Wang, Yuewei Zhang, Shoujun Zhu   +6 more
wiley   +1 more source

Disease-associated marked hyperalphalipoproteinemia

Molecular Genetics and Metabolism Reports, 2014
Marked hyperalphalipoproteinemia (HAL) is a heterogeneous syndrome. To clarify the pathophysiological significance of HAL, we compared clinical profiles between marked HAL subjects with and without cholesteryl ester transfer protein (CETP) deficiency ...
Ken-ichi Hirano, Hironori Nagasaka, Kazuhiro Kobayashi, Satoshi Yamaguchi, Akira Suzuki, Tatsushi Toda, Manabu Doyu   +6 more
doaj   +1 more source

The high‐density lipoprotein lipidome in metabolic syndrome: A systematic review

European Journal of Clinical Investigation, Volume 56, Issue 4, April 2026.
This graphical abstract illustrates the high‐density lipoprotein (HDL) lipidome remodelling in metabolic syndrome (MetS) when compared to control subjects. Alterations occur in both HDL surface and core lipids. On the one hand, surface lipids such as phosphatidylinositol and triacylglycerides are higher in MetS, while free cholesterol, sphingomyelin ...
Elena Grao‐Cruces, Gabriel García‐Jiménez, Maria E. Martin, Gabriele Mocciaro, Elena Osto, Sergio Montserrat‐de la Paz, Lourdes M. Varela   +6 more
wiley   +1 more source

Evaluation of Urine Exosome Lecithin Cholesterol Acyltransferase as a Biomarker for Diabetes Diagnosis and Dyslipidemia

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 3, March 2026.
Integrated proteomic and model studies reveal lipid metabolism dysregulation in diabetes, detectable even in prediabetes. LCAT, a key regulator, shows compensatory upregulation during progression. The characteristic dynamics of urine exosome LCAT provide a basis for its use as a non‐invasive biomarker for early diabetic detection and disease monitoring.
Tianci Liu, Na Liu, Qian Meng, Tao Li, Man Zhang   +4 more
wiley   +1 more source

Low density lipoproteins develop resistance to oxidative modification due to inhibition of cholesteryl ester transfer protein by a monoclonal antibody

Journal of Lipid Research, 2000
Although numerous studies have investigated the relationship between cholesteryl ester transfer protein (CETP) and high density lipoprotein (HDL) remodeling, the relationship between CETP and low density lipoproteins (LDL) is still not fully understood ...
Masahiro Sugano, Shojiro Sawada, Keiko Tsuchida, Naoki Makino, Masafumi Kamada   +4 more
doaj   +1 more source

Nutrigenomics of the Mediterranean Diet: Gene–Diet Interactions and Bioactive Compounds in Cardiovascular Health

Food Frontiers, Volume 7, Issue 2, March 2026.
The Mediterranean diet interacts with genetic and epigenetic backgrounds to modulate nutrigenomic mechanisms, including DNA methylation, histone modification and microRNA regulation. These molecular effects reduce inflammation and oxidative stress, enhance nitric oxide bioavailability and lipid metabolism and translate into improved cardiometabolic ...
Karina Ramírez‐Alarcón, Ana María Labraña, Fernanda Carrasco‐Marín, Pilar Benítez‐Cid, Rafael Zapata‐Lamana, Xavier Capó, Margalida Monserrat‐Mesquida, Antoni Sureda, Héctor Contreras, Francisca Valenzuela‐Mella, Daniel Pacheco Bravo, Daniela Calina, Maria de la Luz Cádiz‐Gurrea, Antonio Segura‐Carretero, William N. Setzer, Javad Sharifi‐Rad, Miquel Martorell   +16 more
wiley   +1 more source

Cholesteryl ester transfer protein inhibitors in the treatment of dyslipidemia: a systematic review and meta-analysis.

PLoS ONE, 2013
Cholesteryl ester transfer protein (CETP) inhibitors are gaining substantial research interest for raising high density lipoprotein cholesterol levels. The aim of the research was to estimate the efficacy and safety of cholesteryl ester transfer protein ...
Chuanwei Li, Wen Zhang, Faying Zhou, Caiyu Chen, Liang Zhou, Yafei Li, Ling Liu, Fang Pei, Hao Luo, Zhangxue Hu, Jing Cai, Chunyu Zeng   +11 more
doaj   +1 more source

Structure-function relationships of human cholesteryl ester transfer protein: analysis using monoclonal antibodies.

Journal of Lipid Research, 1996
Cholesteryl ester transfer protein (CETP), a 476 amino acid glycoprotein, mediates cholesteryl ester (CE), triglyceride, and phospholipid transfer among plasma lipoproteins.
P Roy, R MacKenzie, T Hirama, X C Jiang, P Kussie, A Tall, E Rassart, R Milne   +7 more
doaj   +1 more source

The heterogeneous treatment effects of statins on dementia: a target trial emulation with causal machine learning using integrated genetic and real‐world data

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Given the complexity of dementia, the inconsistent evidence on statins and dementia highlights the need for robust methods to assess heterogeneous treatment effects (HTEs). METHODS We emulated a target trial using UK Biobank comparing statin initiators and non‐initiators aged ≥55 years.
Yongjie Lai, Qoua L Her, Yue Zhang, Hong Xu, Anna Kucharska‐Newton, Dongze Ji, Guorong Wu, Gwenn Garden, Til Stürmer, Tiansheng Wang, Yang Xu   +10 more
wiley   +1 more source