Results 21 to 30 of about 4,882 (132)

Cholesteryl ester transfer proteins from different species do not have equivalent activities[S]

Journal of Lipid Research, 2014
Site-specific changes in the amino acid composition of human cholesteryl ester transfer protein (CETP) modify its preference for triglyceride (TG) versus cholesteryl ester (CE) as substrate.
Richard E. Morton, Lahoucine Izem
doaj   +1 more source

VLDL-bound lipoprotein lipase facilitates the cholesteryl ester transfer protein-mediated transfer of cholesteryl esters from HDL to VLDL

Journal of Lipid Research, 1999
In recent years, it has been established that lipoprotein lipase (LPL) is partly associated with circulating lipoproteins. This report describes the effects of physiological amounts of very low density lipoprotein (VLDL)-bound LPL on the cholesteryl ...
Valérie Pruneta, Thérèse Pulcini, Florent Lalanne, Christophe Marçais, François Berthezène, Gabriel Ponsin, Philippe Moulin   +6 more
doaj   +1 more source

Description of the torcetrapib series of cholesteryl ester transfer protein inhibitors, including mechanism of actions⃞

Journal of Lipid Research, 2006
We have identified a series of potent cholesteryl ester transfer protein (CETP) inhibitors, one member of which, torcetrapib, is undergoing phase 3 clinical trials.
Ronald W. Clark, Roger B. Ruggeri, David Cunningham, Mark J. Bamberger   +3 more
doaj   +1 more source

Modulating cholesteryl ester transfer protein activity maintains efficient pre-β-HDL formation and increases reverse cholesterol transport[S]

Journal of Lipid Research, 2010
The mechanism by which cholesteryl ester transfer protein (CETP) activity affects HDL metabolism was investigated using agents that selectively target CETP (dalcetrapib, torcetrapib, anacetrapib). In contrast with torcetrapib and anacetrapib, dalcetrapib
Eric J. Niesor, Christine Magg, Naoto Ogawa, Hiroshi Okamoto, Elisabeth von der Mark, Hugues Matile, Georg Schmid, Roger G. Clerc, Evelyne Chaput, Denise Blum-Kaelin, Walter Huber, Ralf Thoma, Philippe Pflieger, Makoto Kakutani, Daisuke Takahashi, Gregor Dernick, Cyrille Maugeais   +16 more
doaj   +1 more source

Reduction in the concentration and activity of plasma cholesteryl ester transfer protein by alcohol.

Journal of Lipid Research, 1992
Plasma cholesteryl esters, synthesized within high density lipoproteins (HDL), may be transferred from HDL particles to other lipoproteins by plasma cholesteryl ester transfer protein (CETP).
M Hannuksela, YL Marcel, YA Kesäniemi, MJ Savolainen   +3 more
doaj   +1 more source

Roles of peripheral lipoproteins and cholesteryl ester transfer protein in the vascular contributions to cognitive impairment and dementia

Molecular Neurodegeneration, 2023
This narrative review focuses on the role of cholesteryl ester transfer protein (CETP) and peripheral lipoproteins in the vascular contributions to cognitive impairment and dementia (VCID).
Tetiana Poliakova, Cheryl L. Wellington
doaj   +1 more source

Role of cholesteryl ester transfer protein in selective uptake of high density lipoprotein cholesteryl esters by adipocytes

Journal of Lipid Research, 2004
Previous reports attributed cholesteryl ester transfer protein (CETP)-mediated HDL cholesteryl ester (CE) selective uptake to the CETP-mediated transfer of CE from HDL to newly secreted apolipoprotein B-containing lipoproteins, which are then ...
Gerard Vassiliou, Ruth McPherson
doaj   +1 more source

Comparative effects of purified apolipoproteins A-I, A-II, and A-IV on cholesteryl ester transfer protein activity.

Journal of Lipid Research, 1994
The aim of the present study was to determine in vitro the effects of various purified apolipoproteins (apo) on the activity of the cholesteryl ester transfer protein (CETP).
V Guyard-Dangremont, L Lagrost, P Gambert   +2 more
doaj   +1 more source

How anacetrapib inhibits the activity of the cholesteryl ester transfer protein? Perspective through atomistic simulations. [PDF]

PLoS Computational Biology, 2014
Cholesteryl ester transfer protein (CETP) mediates the reciprocal transfer of neutral lipids (cholesteryl esters, triglycerides) and phospholipids between different lipoprotein fractions in human blood plasma. A novel molecular agent known as anacetrapib
Tarja Äijänen, Artturi Koivuniemi, Matti Javanainen, Sami Rissanen, Tomasz Rog, Ilpo Vattulainen   +5 more
doaj   +1 more source

Allelic variation in the gene encoding the cholesteryl ester transfer protein is associated with variation in the plasma concentrations of cholesteryl ester transfer protein.

Journal of Lipid Research, 1996
The cholesteryl ester transfer protein (CETP) mediates the transfer of cholesteryl esters from high density lipoproteins (HDL) to triglyceride-rich lipoproteins. Mutations that abolish CETP function are associated with very high levels of HDL cholesterol,
R McPherson, S M Grundy, R Guerra, J C Cohen   +3 more
doaj   +1 more source