Results 1 to 10 of about 4,882 (132)

The cholesteryl ester transfer protein (CETP) raises cholesterol levels in the brain [PDF]

Journal of Lipid Research, 2022
The cholesteryl ester transfer protein (CETP) is a lipid transfer protein responsible for the exchange of cholesteryl esters and triglycerides between lipoproteins.
Felix Oestereich, Noosha Yousefpour, Ethan Yang, Jasmine Phénix, Zari Saadati Nezhad, Albert Nitu, Antonio Vázquez Cobá, Alfredo Ribeiro-da-Silva, Pierre Chaurand, Lisa Marie Munter   +9 more
doaj   +4 more sources

Targeting the CTBP1-CETP axis overcomes ferroptosis resistance in non-small cell lung cancer by altering lipid accumulation. [PDF]

Clin Transl Med
CTBP1‐driven CETP activation orchestrates lipid accumulation to suppress MAPK‐dependent ferroptosis in non‐small cell lung cancer. Repurposing the clinical‐stage CETP inhibitor obicetrapib successfully overcomes this resistance in NSCLC patient‐derived organoids, highlighting a promising translational therapeutic strategy. Abstract Background Non‐small
Chen Y, Wang H, Tan X, Yan C, Liu F, Deng S, Wang C, Xia Y, Xu Z, Wu K, Huang S, Chu Q.   +11 more
europepmc   +2 more sources

Evaluation of High-Density Lipoprotein Capacity to Acquire Free Cholesterol From Triglyceride-Rich Lipoproteins During Reverse Remnant-Cholesterol Transport in Familial Hypercholesterolemia. [PDF]

Endocrinol Diabetes Metab
In familial hypercholesterolemia, HDL's absolute capacity to acquire free cholesterol from triglyceride‐rich lipoproteins during lipolysis is preserved, yet normalized HDL function indices relative to LDL‐C and non‐HDL‐C are markedly reduced in homozygous patients, suggesting these ratios as potential biomarkers for identifying high‐risk phenotypes ...
Ganjali S, de Haan JB, Le Goff W, Kontush A, Sahebkar A.   +4 more
europepmc   +2 more sources

Serum Cholesteryl Ester Transfer Protein (CETP) and Sortilin (SORT) in Patients with Psoriasis with Relation to Systemic Treatment [PDF]

Metabolites, 2022
Iwona Flisiak, Julia Nowowiejska, Anna Baran   +2 more
exaly   +2 more sources

Quantitative Prediction of Human Pharmacokinetics and Pharmacodynamics of CKD519, a Potent Inhibitor of Cholesteryl Ester Transfer Protein (CETP) [PDF]

Pharmaceutics, 2019
Suein Choi, Seunghoon Han, Dong-Seok Yim   +2 more
exaly   +2 more sources

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

The effects of curcumin and a modified curcumin formulation on serum Cholesteryl Ester Transfer Protein concentrations in patients with metabolic syndrome: A randomized, placebo-controlled clinical trial [PDF]

Avicenna Journal of Phytomedicine, 2018
Objective: Cholesteryl Ester Transfer Protein (CETP) mediates the transfer of cholesteryl ester from HDL-C to LDL-C and VLDL-C. The aim of the present trial was to evaluate the effect of curcumin and its modified formulation on serum CETP concentrations ...
Ali Javandoost, Asma Afshari, Maryam Saberi Karimian, Amirhosein Sahebkar, Hamideh Safarian Bana, Maliheh Moammeri, Behdokht Fathi Dizaji, Shima Tavalaei, Gordon A. A. Ferns, Alireza Pasdar, Seyed Mohammad Reza Parizadeh, Majid Ghayour Mobarhan   +11 more
doaj   +1 more source

Apolipoprotein E enhances lipid exchange between lipoproteins mediated by cholesteryl ester transfer protein.

Journal of Lipid Research, 1993
The direct effect of apolipoprotein (apo) E on cholesteryl ester transfer protein (CETP) activity was studied using lipoproteins from a subject with apoE deficiency (Atherosclerosis. 1991. 88: 15-20) as a model system.
M Kinoshita, H Arai, M Fukasawa, T Watanabe, K Tsukamoto, Y Hashimoto, K Inoue, K Kurokawa, T Teramoto   +8 more
doaj   +1 more source

Apolipoprotein CI is a physiological regulator of cholesteryl ester transfer protein activity in human plasma but not in rabbit plasma

Journal of Lipid Research, 2009
Plasma cholesteryl ester transfer protein (CETP) activity is high in rabbits, intermediate in humans, and nondetectable in rodents. Human apolipoprotein CI (apoCI) was found to be a potent inhibitor of CETP.
Jean-Paul Pais de Barros, Aurélia Boualam, Thomas Gautier, Laure Dumont, Bruno Vergès, David Masson, Laurent Lagrost   +6 more
doaj   +1 more source

Comparative study of phospholipid transfer activities mediated by cholesteryl ester transfer protein and phospholipid transfer protein.

Journal of Lipid Research, 1994
In the present study, a sequential procedure was set up to separate simultaneously cholesteryl ester transfer protein (CETP), phospholipid transfer protein (PTP), and lecithin:cholesterol acyltransferase (LCAT) from human plasma.
L Lagrost, A Athias, P Gambert, C Lallemant   +3 more
doaj   +1 more source