Results 81 to 90 of about 5,014,718 (261)

Nimodipine reduces microglial activation in vitro as evidenced by morphological phenotype, phagocytic activity and high‐throughput RNA sequencing

open access: yesBritish Journal of Pharmacology, Volume 182, Issue 16, Page 3800-3817, August 2025.
Background and Purpose Nimodipine, an L‐type voltage‐gated calcium channel blocker, is an approved cerebral vasorelaxant. We hypothesized that nimodipine attenuates the pro‐inflammatory shift in microglial phenotypes. Here, we analysed the effects of nimodipine on morphological and functional microglial phenotypes as well as their transcriptomic ...
István Pesti   +10 more
wiley   +1 more source

Aqueous solubility and acidity constants of cholic, deoxycholic, chenodeoxycholic, and ursodeoxycholic acids.

open access: yesJournal of Lipid Research, 1992
Cholic acid, deoxycholic acid, chenodeoxycholic acid, and ursodeoxycholic acid were purified by a foam fractionation method. Using thermogravimetric analysis, the attached water molecule was found to be completely removed from solids of the latter three ...
Y Moroi, M Kitagawa, H Itoh
doaj  

Fermented bile improved growth performance and intestine health by altering metabolic profiles and intestinal microbes in Chinese perch, Siniperca chuatsi

open access: yesJournal of the World Aquaculture Society, Volume 56, Issue 4, August 2025.
Abstract A type of fermented bile acid (BA) named 170HDa was produced using a biological method, and its impacts on growth performance, metabolism, and intestinal microbes in Chinese perch (Siniperca chuatsi) were investigated. Seven experimental diets were established, including treatment groups supplemented with 0.02%–0.06% 170HDa (GN1‐GN5), a ...
Qing Guo   +7 more
wiley   +1 more source

Cofactor requiremets for 7 alpha-dehydroxylation of cholic and chenodeoxycholic acid in cell extracts of the intestinal anaerobic bacterium, Eubacterium species V.P.I. 13708.

open access: yesJournal of Lipid Research, 1981
The characteristics of 7 alpha-dehydroxylase, a bile acid-biotransforming enzyme, were determined using dialyzed cell extracts of Eubacterium sp. V.P.I. 12708. 7 alpha-Dehydroxylase was induced by cholic acid in this organism.
B A White   +5 more
doaj  

Fasting plasma chenodeoxycholic acid and cholic acid concentrations are inversely correlated with insulin sensitivity in adults

open access: yesNutrition and Metabolism, 2011
BackgroundAccumulating data suggest a novel role for bile acids (BAs) in modulating metabolic homeostasis. BA treatment has been shown to improve glucose tolerance and to increase energy expenditure in mice. Here, we investigated the relationship between
Theo Gülen   +5 more
semanticscholar   +1 more source

Determination of 25‐Hydroxyvitamin D3 in Rat Brain by Derivatization‐Assisted LC/ESI‐MS/MS

open access: yesBiomedical Chromatography, Volume 39, Issue 7, July 2025.
ABSTRACT Recent studies have suggested that vitamin D deficiency may have relations with various neuropsychiatric diseases as well as bone diseases. However, the concentrations of vitamin D metabolites in the brain and the relationship between their brain and serum concentrations remain poorly understood.
Toma Shibuya   +4 more
wiley   +1 more source

Mechanochemical Aerobic Activation of Metallic Copper for the Synthesis of 1,4‐Allenynes

open access: yesChemSusChem, Volume 18, Issue 13, July 1, 2025.
In a copper of hours. A sustainable mechanochemical approach to synthesize conjugated allenynes via copper‐catalyzed homocoupling of propargylic esters is reported. Using ball milling, cheap Cu0 from powders and recycled materials to generate catalytically active CuI species under aerobic conditions is activated.
Ana M. Constantin   +6 more
wiley   +1 more source

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