Results 81 to 90 of about 5,133,102 (254)

Biochemical and Physiological Effects of Galanin in Health and Disease

open access: yesThe FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Galanin is a biologically active neuropeptide hormone that mediates its effects through three galanin receptors. Galanin signaling induces changes in glucose homeostasis amongst others and plays a dynamic role in the physiological health of many organ systems.
Patrick Mireles   +3 more
wiley   +1 more source

Molecular Simulations of Polymer‐based Drug Nanocarriers: From Physical and Structural Properties to Controlled Release

open access: yesAdvanced Healthcare Materials, Volume 15, Issue 4, 26 January 2026.
Polymer‐based drug delivery systems can effectively overcome the limitations of free drugs in terms of solubility, stability, and plasma half‐life, yet their development has traditionally relied on time‐consuming trial‐and‐error approaches. This review highlights recent advances in applying molecular simulation to the design of polymer‐based drug ...
Ping Gao   +4 more
wiley   +1 more source

Effects of cholesterol feeding on synthesis and metabolism of cholesterol and bile acids in germfree rats

open access: yesJournal of Lipid Research, 1977
The aim of the present investigation was to study the influence of cholesterol feeding on cholesterol synthesis and fecal excretion of bile acids in germfree rats.
B E Gustafsson, Dr   +3 more
doaj   +1 more source

Synthesis via RAFT polymerization of thermo- and pH-responsive random copolymers containing cholic acid moieties and their self-assembly in water

open access: yes, 2014
Here we report the design and synthesis of polymers containing cholic acid pendant groups, a major bile acid synthesized in the liver from cholesterol.
Sunirmal Pal, Saswati Roy, Priyadarsi De
semanticscholar   +1 more source

Reticular Frameworks for Advanced Polymer Materials

open access: yesAdvanced Materials, Volume 38, Issue 4, 16 January 2026.
Reticular frameworks (RFs) such as metal–organic frameworks, covalent organic frameworks, and hydrogen‐bonded organic frameworks offer versatile platforms for polymer materials innovation, enabling regulated polymerization, efficient macromolecular purification, and polymer functionalization.
Bohan Cheng   +2 more
wiley   +1 more source

Bile Acids as Key Mediators of the Gut Microbiota–Immune Axis: Potential Biomarker and Therapeutic Perspectives

open access: yesBioFactors, Volume 52, Issue 1, January/February 2026.
Primary bile acids synthesized in the liver are transformed by gut microbes into secondary bile acids that engage receptors such as FXR and TGR5, thereby modulating immune function and metabolic homeostasis. Dysregulation of these signaling pathways contributes to MASH, NAFLD, IBD, and neurodegenerative disorders, underscoring their relevance as ...
Simone Baldi   +5 more
wiley   +1 more source

Microbial Chemical Diversity and Cytotoxic Potential From Brazilian Ferruginous Caves: A Pioneering Metabolomic Survey

open access: yesChemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT Cave microbiomes represent a rich yet understudied source of chemical diversity with biotechnological properties. Microorganisms in these environments thrive under extreme conditions such as darkness, oligotrophy, and high concentrations of inorganic matter like iron ore.
Natália Naomi Kato   +5 more
wiley   +1 more source

Effect of ethynylestradiol on biliary excretion of bile acids, phosphatidylcolines, and cholesterol in the bile fistula rat1

open access: yesJournal of Lipid Research, 1977
The effects of ethynylestradiol on endogenous bile acids, their capacity to conjugate and excrete intravenously infused cholic acid, the concentrations of biliary cholesterol and lecithin, and the individual molecular species of phosphatidylcholine have ...
F Kern, Jr   +3 more
doaj   +1 more source

Effects of cholic acid on the metabolism of endogenous plasma triglyceride and on biliary lipid composition in hyperlipoproteinemia.

open access: yesJournal of Lipid Research, 1980
Plasma lipids, endogenous triglyceride kinetics, and biliary lipid composition were determined in 13 patients with primary hyperlipoproteinemia (HLP) before and during treatment with cholic acid (15 mg/kg body weight/day for 3 months).
B Angelin, B Leijd
doaj   +1 more source

Changes in biliary and fecal bile acids in mice after treatments with diosgenin and beta-sitosterol.

open access: yesJournal of Lipid Research, 1984
Diosgenin and beta-sitosterol (1% in diet) were administered to CRJ:CD-1 male mice for 15 days, in order to examine the changes in bile acid metabolism.
K Uchida   +5 more
doaj   +1 more source

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