Results 61 to 70 of about 2,533,937 (176)
Clinical Pharmacology &Therapeutics, EarlyView.Rifampicin is a prototypical clinical inducer used in drug–drug interaction (DDI) studies. However, the clinical relevance and predictability of rifampicin‐mediated hepatic transporter induction remain poorly defined. Conventional hepatocyte culture models fail to capture clinically relevant regulation of transporters and drug‐metabolizing enzymes ...
Mattie E. Hartauer +9 more
wiley +1 more source
Bile acid formation in man: metabolism of 7α-hydroxy-4-cholesten-3-one in bile fistula patients
Journal of Lipid Research, 1973 7α-Hydroxy-4-cholesten-3-one is thought to be an intermediate in human bile acid synthesis. This conclusion is based on in vivo experiments in animals and on in vitro studies in which homogenates of animal and human livers were used. To further establish
Russell F. Hanson +2 more
doaj +1 more source
Chemotactic responses to a mixture of cholic acid and lithocholic acid.
, 2018 Chemotactic migration of CsNEJs to a mixed solution of cholic acid and lithocholic acid was examined in 1 h. The mixed solution was made of 50 mM cholic acid and lithocholic acid at concentrations of 0.13–8 mM (A), or 1 mM lithocholic acid and cholic ...
Won Gi Yoo (193369) +4 more
core +1 more source
Journal of Lipid Research, 1984 Isotope dilution within bile acid pools and radiochemical assessment of cholesterol oxidation to bile acids were methods used to measure short-term feedback regulation of bile acid synthesis in baboons with controlled enterohepatic circulations ...
R N Redinger
doaj +1 more source
JPGN Reports, EarlyView.Abstract Cerebrotendinous xanthomatosis (CTX) is a treatable genetic disorder associated with deficiency of the sterol 27‐hydroxylase enzyme (CYP27A1), important in bile acid synthesis. CTX may present in the newborn period as hepatic jaundice/cholestasis, that can resolve or can progress to fatal liver disease.
Andrea E. DeBarber +3 more
wiley +1 more source
Journal of Lipid Research, 1991 We previously reported that the 7 alpha-dehydroxylation of cholic acid appears to be carried out by a multi-step pathway in intestinal anaerobic bacteria both in vitro and in vivo.
PB Hylemon +4 more
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Bile acids drive chemotaxis of Clonorchis sinensis juveniles to the bile duct. [PDF]
PLoS Neglected Tropical Diseases, 2018 Clonorchiasis is a neglected tropical disease caused by Chinese liver fluke, Clonorchis sinensis infection. C. sinensis is a biological carcinogen causing cholangiocarcinoma in humans. In the mammalian host, C.
Shunyu Li +4 more
doaj +1 more source
JEADV Clinical Practice, EarlyView.Chronic kidney disease‐associated pruritus (CKDaP) is a frequent complication of advanced CKD with an incompletely understood pathophysiology. We identified a significantly altered glycine‐to‐taurine conjugated bile acid ratio in patients with CKDaP despite unchanged total serum bile acid concentrations.
Miriam M. Düll +6 more
wiley +1 more source
Journal of Lipid Research, 1988 We have previously observed that the Ya subunit-containing glutathione (GSH) S-transferases from rat liver exhibit a common high affinity binding site for lithocholic acid, bilirubin, and sulfobromophthalein (BSP) (1984. J. Lipid Res.
H Takikawa, N Kaplowitz
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The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as the most prevalent chronic liver disease worldwide, closely linked to the global rising incidence of obesity and metabolic syndrome. This review synthesizes current evidence on the pathogenesis, gut–liver axis, and multidisciplinary management of MASLD within the ...
Beom Kyung Kim
wiley +1 more source