Results 91 to 100 of about 236,274 (244)

A companion to the preclinical common data elements and case report forms for in vivo rodent neuroimaging: A report of the TASK3‐WG3 Neuroimaging Working Group of the ILAE/AES Joint Translational Task Force

open access: yesEpilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force established the TASK3 working groups to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Erwin A. van Vliet   +9 more
wiley   +1 more source

Natural History and Diagnostic Findings in an Adult Man Diagnosed With Attenuated Krabbe Disease

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Krabbe disease (KD), or globoid cell leukodystrophy, is a rare autosomal recessive lysosomal storage disorder caused by a deficiency in galactocerebrosidase (GALC), leading to psychosine (galactosylsphingosine) accumulation and myelin damage.
Eamon P. McCarron   +8 more
wiley   +1 more source

A glance at imaging bladder cancer. [PDF]

open access: yes, 2018
Purpose: Early and accurate diagnosis of Bladder cancer (BCa) will contribute extensively to the management of the disease. The purpose of this review was to briefly describe the conventional imaging methods and other novel imaging modalities used for ...
Halpern, Ethan J.   +4 more
core   +1 more source

Towards Polymer Composite‐Based Transient Electronic Systems

open access: yesAdvanced NanoBiomed Research, EarlyView.
Biodegradable electronic systems are gaining attention for implantable biomedical applications, targeting disease treatment and lifespan extension. This review covers advances in biocompatible, biodegradable polymer composites using synthetic and natural polymers with conductive, semiconductive, and insulating fillers.
Gwan‐Jin Ko   +5 more
wiley   +1 more source

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

open access: yesHepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim   +12 more
wiley   +1 more source

Metabolomics analysis of children with autism, idiopathic-developmental delays, and Down syndrome. [PDF]

open access: yes, 2019
Although developmental delays affect learning, language, and behavior, some evidence suggests the presence of disturbances in metabolism are associated with psychiatric disorders.
Abbeduto, Leonard   +3 more
core   +1 more source

Photoaktivierbares enzymatisches Reaktionsnetzwerk ermöglicht zeitliche und räumliche Programmierung von Thiol/Disulfid‐Redoxsystemen

open access: yesAngewandte Chemie, EarlyView.
Diese Arbeit stellt ein redox‐basiertes enzymatisches Reaktionsnetzwerk vor, das photoaktiviert und mehrmals betankt werden kann, um dissipative Disulfidbildung aufrechtzuerhalten. Dieses innovative System integriert einen vorgeschalteten oxidativen enzymatischen Prozess mit einem nachgeschalteten Reduktionsmittel‐regenerierendem enzymatischen ...
Aritra Sarkar   +4 more
wiley   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

open access: yesHepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario   +12 more
wiley   +1 more source

Adaptation to Choline Deprivation: Choline Redistribution and Choline Storage

open access: yesThe FASEB Journal, 2006
Luis B. Agellon   +2 more
openaire   +2 more sources

Photoactivated Enzymatic Reaction Network Enables Spatiotemporal Programming of Thiol/Disulfide Redox Systems

open access: yesAngewandte Chemie International Edition, EarlyView.
This work introduces a redox‐based enzymatic reaction network that can be photoactivated and recharged multiple times to sustain dissipative disulfide formation. The innovative system integrates an upstream oxidative enzymatic process with a downstream reducing agent‐regenerating enzymatic mechanism.
Aritra Sarkar   +4 more
wiley   +1 more source

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