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Choline Acetyltransferase

CRC Critical Reviews in Biochemistry, 1977
Acetylcholine is essential to neural function. It synthesis is catalyzed by choline acetyltransferase, the enzyme responsible for the acetylation of choline by acetyl coenzye A, a reaction favored slightly thermodymodynamically and not at all kinetically. An analytically pure enzyme still has not been obtained; however, method of purification have been
Henry G. Mautner, David Nachmansohn
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Biosensors for choline, choline esters and inhibitors of choline esterase

Sensors and Actuators B: Chemical, 1991
Abstract A choline electrode has been developed by coupling immobilized choline oxidase to a hydrogen peroxide electrode. The co-immobilization of cholinesterase permits acetylcholine to be measured. The excess of both enzymes results in a diffusion-limited electrode response for both substrates, with relative sensitivities 1: 0.6 for choline ...
U. Wollenberger   +5 more
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The Transport of Choline

Drug Development and Industrial Pharmacy, 2002
Choline has many physiological functions throughout the body that are dependent on its available local supply. However, since choline is a charged hydrophilic cation, transport mechanisms are required for it to cross biological membranes. Choline transport is required for cellular membrane construction and is the rate-limiting step for acetylcholine ...
P R, Lockman, D D, Allen
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Choline oxidation and choline dehydrogenase

Journal of Protein Chemistry, 1986
The oxidation of choline by both freshly prepared and aged rat liver mitochondria is inhibited by amytal. Whereas rotenone inhibits choline-cytochromec reductase only in the case of freshly prepared mitochondria, the extent of inhibition is influenced by preincubation, but the inhibition is not secondary to the inhibited oxidation of betaine aldehyde ...
Chi-Shui Lin, Ru-Dan Wu
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