Results 11 to 20 of about 262,114 (295)

Choline Redistribution during Adaptation to Choline Deprivation [PDF]

Journal of Biological Chemistry, 2007
Choline is an important nutrient for mammals. Choline can also be generated by the catabolism of phosphatidylcholine synthesized in the liver by the methylation of phosphatidylethanolamine by phosphatidylethanolamine N-methyltransferase (PEMT). Complete choline deprivation is achieved by feeding Pemt(-)(/)(-) mice a choline-deficient diet and is lethal
Zhaoyu, Li, Luis B, Agellon, Dennis E, Vance   +2 more
openaire   +2 more sources

Integrating Choline and Specific Intestinal Microbiota to Classify Type 2 Diabetes in Adults: A Machine Learning Based Metagenomics Study

Frontiers in Endocrinology, 2022
Emerging evidence is examining the precise role of intestinal microbiota in the pathogenesis of type 2 diabetes. The aim of this study was to investigate the association of intestinal microbiota and microbiota-generated metabolites with glucose ...
Qiang Zeng, Mingming Zhao, Mingming Zhao, Fei Wang, Yanping Li, Huimin Li, Huimin Li, Jianqiong Zheng, Xianyang Chen, Xianyang Chen, Xiaolan Zhao, Liang Ji, Xiangyang Gao, Changjie Liu, Yu Wang, Si Cheng, Jie Xu, Bing Pan, Jing Sun, Yongli Li, Dongfang Li, Dongfang Li, Yuan He, Yuan He, Lemin Zheng, Lemin Zheng   +25 more
doaj   +1 more source

Functional genomics with a comprehensive library of transposon mutants for the sulfate-reducing bacterium Desulfovibrio alaskensis G20. [PDF]

, 2014
UnlabelledThe genomes of sulfate-reducing bacteria remain poorly characterized, largely due to a paucity of experimental data and genetic tools. To meet this challenge, we generated an archived library of 15,477 mapped transposon insertion mutants in the
Arkin, Adam P, Davis, Ronald W, Deutschbauer, Adam, Esquivel, Zuelma, Hazen, Terry C, Kazakov, Alexey E, Kuehl, Jennifer V, Kuehn, Raquel, Nguyen, Michelle, Price, Morgan N, Ray, Jayashree, Wetmore, Kelly M   +11 more
core   +2 more sources

Choline metabolism and membrane formation in rat hepatoma cells grown in suspension culture. III. Choline transport and uptake by simple diffusion and lack of direct exchange with phosphatidylcholine

Journal of Lipid Research, 1971
The initial rate of incorporation of methyl-labeled choline into the acid-soluble pool (phosphorylcholine) of Novikoff hepatoma cells growing in suspension culture was investigated as a function of the choline concentration in the medium.
PETER G.W. PLAGEMAEN
doaj   +1 more source

Dysregulated Choline, Methionine, and Aromatic Amino Acid Metabolism in Patients with Wilson Disease: Exploratory Metabolomic Profiling and Implications for Hepatic and Neurologic Phenotypes. [PDF]

, 2019
Wilson disease (WD) is a genetic copper overload condition characterized by hepatic and neuropsychiatric symptoms with a not well-understood pathogenesis.
Czlonkowska, Anna, Kim, Kyoungmi, Litwin, Tomasz, Mazi, Tagreed A, Medici, Valentina, Sarode, Gaurav V, Shibata, Noreene M   +6 more
core   +2 more sources

Biosynthesis of phosphatidyl choline during prenatal development of the rat lung

Journal of Lipid Research, 1968
The biosynthesis of phosphatidyl choline in rat lung during prenatal development is of interest in connection with the mechanisms of functional development of the lung, particularly in relation to the production of lung surfactant and the control of ...
Paul A. Weinhold
doaj   +1 more source

Maternal nutritional status, C1 metabolism and offspring DNA methylation: a review of current evidence in human subjects. [PDF]

, 2011
: Evidence is growing for the long-term effects of environmental factors during early-life on later disease susceptibility. It is believed that epigenetic mechanisms (changes in gene function not mediated by DNA sequence alteration), particularly DNA ...
Cox, SE, Dominguez-Salas, P, Hennig, BJ, Moore, SE, Prentice, AM   +4 more
core   +4 more sources

The Diagnostic Role of 18F-Choline, 18F-Fluciclovine and 18F-PSMA PET/CT in the Detection of Prostate Cancer With Biochemical Recurrence: A Meta-Analysis

Frontiers in Oncology, 2021
BackgroundDiagnosing the biochemical recurrence (BCR) of prostate cancer (PCa) is a clinical challenge, and early detection of BCR can help patients receive optimal treatment. We conducted a meta-analysis to define the diagnostic accuracy of PET/CT using
Rang Wang, Guohua Shen, Mingxing Huang, Rong Tian   +3 more
doaj   +1 more source

Does litomosoides sigmodontis synthesize dimethylethanolamine from choline? [PDF]

, 2008
Juvenile female Litomosoides sigmodontis secrete a protein (Juv-p120) highly modified with dimethylethanolamine (DMAE). In an attempt to establish the source of this decoration worms were pulsed with [3H]-choline and [3H]-ethanolamine and the radio ...
Allen, J E, Allen, Judith, Babayan, S A, Harnett, W, Houston, K M   +4 more
core   +2 more sources

Anticancer activity of rutin and its combination with ionic liquids on renal cells [PDF]

, 2020
The renal cell carcinoma (RCC) is the most common type of kidney cancer. Identifying novel and more effective therapies, while minimizing toxicity, continues to be fundamental in curtailing RCC.
Araújo, Maria Eduarda Machado, Baby, André Rolim, Caparica, Rita, Costa, João Guilherme, Fonte, Pedro, Júlio, Ana, Santos de Almeida, Tânia   +6 more
core   +1 more source