Results 41 to 50 of about 187,609 (208)

Elusive physiological role of prostatic acid phosphatase (PAP): generation of choline for sperm motility via auto-and paracrine cholinergic signaling

Frontiers in Physiology, 2023
Prostatic acid phosphatase (PAP) exists as two splice variants, secreted PAP and transmembrane PAP, the latter of which is implicated in antinociceptive signaling in dorsal root ganglia.
Peter J. Hanley
doaj   +1 more source

DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women. [PDF]

, 2013
BACKGROUND: Animal models show that periconceptional supplementation with folic acid, vitamin B-12, choline, and betaine can induce differences in offspring phenotype mediated by epigenetic changes in DNA. In humans, altered DNA methylation patterns have
Dominguez Salas, Paula, Dyer, Roger A, Andrew M Prentice, Waterland, Robert A., Kerry-Ann da Costa, Cole, Darren, Zeisel, Steven H., Prentice, Andrew M, Hennig, Branwen J, Paula Dominguez-Salas, Sophie E Moore, Moore, Sophie E, Zeisel, Steven H, Anthony JC Fulford, Moore, Sophie E., Robert A Waterland, Darren Cole, Fulford, Anthony JC, Branwen J Hennig, Dyer, Roger A., Fulford, Anthony J.C., Sharon E Cox, Sheila M Innis, Steven H Zeisel, Dominguez-Salas, Paula, Innis, Sheila M, da Costa, Kerry-Ann, Roger A Dyer, Waterland, Robert A, Innis, Sheila M., Cox, Sharon E, Prentice, Andrew M., Da Costa, Kerry Ann, Hennig, Branwen J., Cox, Sharon E.   +34 more
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Fine-tuning of choline metabolism is important for pneumococcal colonization [PDF]

, 2016
The human pathogen Streptococcus pneumoniae (the pneumococcus) is rare in having a strict requirement for the amino alcohol choline, which decorates pneumococcal teichoic acids.
Bootsma, H.J., Polard, P., Peter W. M. Hermans, Hauser, C., Hester J. Bootsma, Claverys, Jean‐pierre, Johnston, Calum, Jean-Pierre Claverys, Hermans, Peter W.M., Calum Johnston, Johnston, C., Hermans, P.W.M., Christoph Hauser, Bootsma, Hester J., Claverys, J.P., Polard, Patrice, Hauser, Christoph, Martin, Bernard, Martin, B., Claverys, Jean-Pierre, Patrice Polard, Bernard Martin, Bootsma, Hester, J, Hermans, Peter, W M   +23 more
core   +1 more source

Understanding Choline Bioavailability and Utilization: First Step Toward Personalizing Choline Nutrition

, 2021
Choline is an essential macronutrient involved in neurotransmitter synthesis, cell-membrane signaling, lipid transport, and methyl-group metabolism. Nevertheless, the vast majority are not meeting the recommended intake requirement. Choline deficiency is
Cheam, Guoxiang, Wang, Yulan, Ying Qi Goh, Goh, Ying Qi, Yulan Wang, Guoxiang Cheam   +5 more
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Choline metabolome response to prenatal choline supplementation across pregnancy: A randomized controlled trial. [PDF]

, 2021
Pregnancy places a unique stress upon choline metabolism, requiring adaptations to support both maternal and fetal requirements. The impact of pregnancy and prenatal choline supplementation on choline and its metabolome in free-living, healthy adults is ...
Devapatla, Srisatish, Caudill, Marie, Bender, Erica, Malysheva, Olga, Nevins, Julie, Taesuwan, Siraphat, McDougall, Melissa, Vidavalur, Ramesh, Klatt, Kevin, Marie A. Caudill, Nevins, Julie E. H., Srisatish Devapatla, Erica Bender, Melissa Q. McDougall, Julie E. H. Nevins, Caudill, Marie A., Klatt, Kevin C., Ramesh Vidavalur, Malysheva, Olga V., Olga V. Malysheva, Kevin C. Klatt, McDougall, Melissa Q., Siraphat Taesuwan   +22 more
core   +1 more source

Gut Microbiota Targeted Approach in the Management of Chronic Liver Diseases

Frontiers in Cellular and Infection Microbiology, 2022
The liver is directly connected to the intestines through the portal vein, which enables the gut microbiota and gut-derived products to influence liver health.
Jing Liu, Dakai Yang, Xiaojing Wang, Paul Tetteh Asare, Qingwen Zhang, Lixin Na, Lei Shao   +6 more
doaj   +1 more source

Rumen-protected choline and vitamin E supplementation in periparturient dairy goats: effects on milk production and folate, vitamin B12 and vitamin E status

Animal, 2008
We investigated the effects of rumen-protected choline (RPC) and vitamin E (VITE) administration on milk production and status of folate, vitamin B12 and vitamin E during the periparturient period of dairy goats. Forty-eight Saanen multiparous goats were
L. Pinotti, A. Campagnoli, F. D’Ambrosio, F. Susca, M. Innocenti, R. Rebucci, E. Fusi, F. Cheli, G. Savoini, V. Dell’Orto, A. Baldi   +10 more
doaj   +1 more source

Physiological characteristics, dry matter, and active component accumulation patterns of Changium smyrnioides in response to a light intensity gradient

Pharmaceutical Biology, 2017
Context: Changium smyrnioides Wolff (Apiaceae) is an endangered medicinal plant with numerous pharmacological uses. Objective: To investigate the effect of light intensity levels on the growth and accumulation of secondary metabolites of C.
Chang-lin Wang, Qiao-sheng Guo, Zai-biao Zhu, Bo-xing Cheng   +3 more
doaj   +1 more source

Vitamin B12 impacts amyloid beta-induced proteotoxicity by regulating the methionine/S-adenosylmethionine cycle

Cell Reports, 2021
Summary: Alzheimer’s disease (AD) is a devastating neurodegenerative disorder with no effective treatment. Diet, as a modifiable risk factor for AD, could potentially be targeted to slow disease onset and progression.
Andy B. Lam, Kirsten Kervin, Jessica E. Tanis   +2 more
doaj   +1 more source

The Response of RIF-1 Fibrosarcomas to the Vascular-Disrupting Agent ZD6126 Assessed by In Vivo and Ex Vivo1H Magnetic Resonance Spectroscopy

Neoplasia: An International Journal for Oncology Research, 2006
The response of radiation-induced fibrosarcoma1 (RIF-1) tumors treated with the vascular-disrupting agent (VDA) ZD6126 was assessed by in vivo and ex vivo1H magnetic resonance spectroscopy (MRS) methods.
Basetti Madhu, John C. Waterton, John R. Griffiths, Anderson J. Ryan, Simon P. Robinson   +4 more
doaj   +1 more source