Results 191 to 200 of about 1,083,054 (280)

Prenatal choline deficiency does not enhance hippocampal vulnerability after kainic acid-induced seizures in adulthood.

Brain Research, 2011
Sarah J. E. Wong-Goodrich, Christina M. Tognoni, Tiffany J Mellott, Melissa J Glenn, J. Blusztajn, Christina L. Williams   +5 more
semanticscholar   +1 more source

Brain Pericytes and Wnt/β‐Catenin Signaling Induce Functional Blood–Brain Barrier Phenotype in Human iPSC‐Derived Model

Small Methods, EarlyView.
This study shows that human iPSC‐derived endothelial cells acquire a functional blood–brain barrier phenotype when co‐cultured with brain pericytes and stimulated with CHIR‐99021, a Wnt/β‐catenin activator. This model recapitulates key barrier properties, inflammatory responses, and transcriptomic features of the native human BBB, offering new ...
Henrique Nogueira Pinto, Nine R. Kok, Philipp C. Hauger, Manon Karsten‐van Diepen, Michael de Kok, Nanne J. Paauw, Susanne M. A. van der Pol, Joline P. Nugteren‐Boogaard, Peter L. Hordijk, Stephanie D. Beekhuis‐Hoekstra, Susan Gibbs, Nienke M. de Wit, Helga E. de Vries   +12 more
wiley   +1 more source

Acetylcholine From Solitary Chemosensory Cell, Not Neuron, Regulates Basal Cell Fate Driving Eosinophilic Chronic Rhinosinusitis With Nasal Polyps

Allergy, EarlyView.
This study identifies that Ach levels are elevated in eCRSwNP and primarily released from SCCs rather than neurons. Ach induces epithelial remodeling in eCRSwNP by binding to M1R/M3R and activating YAP signaling in basal cells, driving basal cell hyperplasia and abnormal differentiation. Blocking M1R/M3R with TB inhibits eCRSwNP progression.
Bowen Zheng, Tao Lu, Ji Wang, Yalan Zhang, Panhui Xiong, Jieyu Zeng, Shuman Li, Yu Jiang, Yijun Liu, Longlan Shu, Yuan Chen, Yin Zhou, Yue Gu, Dayu Guan, Chenxi Li, Lei Zhao, Shujin Wang, Jie Liu, Xia Ke, Yang Shen, Yucheng Yang   +20 more
wiley   +1 more source

Selected Lipidome Components and Their Association with Perinatal Depression. [PDF]

Nutrients
Ładno D, Nowak B, Palka A, Strzelecki D, Gawlik-Kotelnicka O.   +4 more
europepmc   +1 more source

The Therapeutic Potential of Farm Dust Extracts in a Mouse Model of Eosinophilic Inflammation

Allergy, EarlyView.
Farm dust extract (FDE) treatment reduces airway eosinophilia, mucus overproduction, and MHC‐II expression on DCs, limiting antigen presentation and Th2 inflammation. It increases PD‐L1 on DCs, promoting T cell deactivation. Additionally, FDE enhances Tregs and upregulates CTLA‐4, reinforcing suppression.
Rabia Ülkü Korkmaz, Jimmy Omony, Xiaomei Tan, Markus Klotz, Guilherme Dragunas, Sirui Chen, Soni Shankhwar, Zeynep Ertüz, Christoph Müller, Mohab Ragab, Aicha Jeridi, Romina Augustin, Janna Nawroth, Theodore S. Kapellos, Bettina Rankl, Ali Önder Yildirim, Erika von Mutius   +16 more
wiley   +1 more source

Vitamins and minerals and their role in cancer: a comprehensive review. [PDF]

Front Nutr
Garutti M, de Scordilli M, Alberti M, Mazzeo R, Michelotti A, Fagioli S, Del Conte A, Casirati A, Caccialanza R, Bartolini E, Puglisi F.   +10 more
europepmc   +1 more source

Methionine and Serine Synergistically Suppress Hyperhomocysteinemia Induced by Choline Deficiency, but Not by Guanidinoacetic Acid, in Rats Fed a Low Casein Diet

Bioscience, biotechnology and biochemistry, 2011
Yi-qun Liu, Y. Liu, T. Morita, K. Sugiyama   +3 more
semanticscholar   +1 more source

Cannabigerol reverses mechanical allodynia through α2A‐adrenergic modulation of thalamocortical signaling in chemotherapy‐induced neuropathy

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade, Nathan Morris, Diana E. Sepulveda, Alonso Cortez‐Resendiz, Christopher Brandl, Jennifer E. Lausch, Mariya Starostina, Nicholas M. Graziane   +7 more
wiley   +1 more source

Choline-Mediated Regulation of Follicular Growth: Interplay Between Steroid Synthesis, Epigenetics, and Oocyte Development. [PDF]

Biology (Basel)
Liu W, Zheng X, Yang H, Wang Z.
europepmc   +1 more source

Effect of Choline Deficiency on Serum Phospholipids in Chicks

, 1972
Eli Seifter, G Rettura, Stanley Μ. Levenson   +2 more
openalex   +1 more source